Acta Scientific Clinical Case Reports

Research ArticleVolume 3 Issue 4

Features of Helicobacter pylori Infection in Patients with Diffuse and Intestinal Gastric Cancer According to a Urease Test, Operated Under the Conditions of "Multidisciplinary Medical Center" of Nur-Sultan

Stefanov II1,2, Kulmambetova GN3, Zholdybaeva EV3, Zharkeneva MB1,2, Gubskaya EB2, Pirozhenko OL2, Amangeldina AA Kukanova AM1,2*, Bekisheva AT1,and Makishev AK1,2

1NJSC "Astana Medical University", Nur-Sultan
2"Multidisciplinary Medical Center", Nur-Sultan
3RGP "National Center of Biotechnology" KN MES RK, Nur-Sultan

*Corresponding Author: Kukanova AM, NJSC "Astana Medical University", Nur-Sultan.

Received: December 23, 2021; Published: March 21, 2022

Abstract

Helicobacter pylori was discovered by Australian scientists B. J. Marshall and J. R. Warren in 1983, which caused incredible progress in gastroenterology [1]. In scientific studies, as well as in 1994, the International Agency for Research on Cancer attributed helicobacter infection to carcinogens of the first order [2,3]. The Lauren classification, proposed back in the 60s, divided gastric adenocarcinoma into two main histological types: 1-well-differentiated or intestinal type, and 2-undifferentiated or diffuse type [4]. According to literature sources [5], diffuse gastric cancer arises from the normal gastric mucosa without any precancerous stage and is often not associated with Helicobacter pylori. Others [6] also indicate that when 1246 patients with various Helicobacter pylori-associated gastroduodenal diseases were observed for 8 years, stomach cancer was detected in 36 (2.9%) of them, including 23 cases with intestinal and 13 with its diffuse form. According to [7], the infection rate of patients with stomach cancer in the Orenburg region of Russia with various histological forms of stomach cancer is 85.7% of cases with G2 gastric adenocarcinomas, in 61% of cases of ring-cell cancer, in 50% of cases of G3 and G4 gastric cancer, in 45% of cases of highly differentiated gastric adenocarcinomas and in 70% of cases with other histological forms of stomach cancer. In our study, we tried to clarify the situation of the relationship of diffuse stomach cancer with Helicobacter pylori infection in patients operated in the MMC of Nur-Sultan.

Keywords: Diffuse Gastric Cancer; Intestinal Gastric Cancer; Helicobacter pylori; Infection

Bibliography

  1. Warren JR and Marshall B. “Unidentified curved bacilli on gastric epithelium in active chronic gastritis”. Lancet 8336 (1983): 1273-1275.
  2. Forman D. “Helicobacter pylori: the gastric cancer problem”. Gut 43 (1998): S33-S34.
  3. Working Group. “IARC Monographs on the Evaluation of Carcinogenic Risk to Humans”. Schistosomes, liver flukes and Helicobacter Pylori, Lyon, France: IARC 61 (1994).
  4. Lauren P. “The two histological main types of gastric carcinoma: diffuse and so-called intestinal type carcinoma. An attempt at a histoloclinical classification”. Acta Pathologica, Microbiologica, et Immunologica Scandinavica 6 (1965): 31-49.
  5. McLean MH and El-Omar EM. “Genetics of gastric cancer". Nature Reviews Gastroenterology and Hepatology 11 (2014): 664-674.
  6. https://meddaily.info/?cat=article&id=1006
  7. Senchukova MA, et al. “Infection of gastric cancer patients with Helicobacter Pylori in the Orenburg region according to the rapid urease test”. Bulletin of RONTS im. N.N. Blokhin RAMS. 20.3 (2003): 68-73.
  8. Marshall BJ., et al. “Rapid urease test in the management of Campylobacter pyloridis associated gastritis”. The American Journal of Gastroenterology 82 (1987): 200-210.
  9. Isakov VA and Domaradsky IV. "Helicobacter pylori". ID Medpraktika M (2003): 1-412.
  10. Sheptulin AA and Kyprianis VA. “Diagnosis and treatment of Helicobacter pylori infection: key points from the Maastricht 3 consensus meeting”. Ross. f. gastroenterol. hepatol. Coloproctol 16.2 (2006): 88-91.Malfertheiner P., et al. “Guidelines for management of H. pylori infection. Summary of the Maastricht 3, 2005 consensus report”. Suchasna Gastroenterology5 (2005): 84-87.
  11. Malfertheiner P., et al. “Management of Helicobacter pylori infection the Maastricht-IV / Florence Consensus Report”. Gut 61 (2012): 646-664.
  12. Langenberg ML., et al. “Campylobacter like organisms in the stomach of patients and healthy individuals”. Lancet 1 (1984): 1348.
  13. McNulty CAM and Wise R. “Rapid diagnosis of Campylobacter associated gastritis”. Lancet 1 (1985): 1443-1444.
  14. Wu CH., et al. “Overexpression of Helicobacter pylori-associated urease mRNAs in human gastric cancer”. DNA Cell Biology9 (2007): 641-648.

Citation: Kukanova AM., et al. “Features of Helicobacter pylori Infection in Patients with Diffuse and Intestinal Gastric Cancer According to a Urease Test, Operated Under the Conditions of "Multidisciplinary Medical Center" of Nur-Sultan". Acta Scientific Clinical Case Reports 3.4 (2022): 64-67.

Copyright: © 2022 Kukanova AM and Stefanov II., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.