Acta Scientific Clinical Case Reports

Case ReportVolume 3 Issue 2

Bilateral Nonarteritic Anterior Ischemic Optic Neuropathy in a Glanzmann Disease

Dina T Mohammed1, Eman Ragab2 and Mohammad A Rashad1*

1Ophthalmology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2Pediatrics Department, Faculty of Medicine, Ain shams University, Cairo, Egypt

*Corresponding Author: Mohammad A Rashad, Ophthalmology Department, Faculty of Medicine, Ain shams University, Cairo, Egypt.

Received: January 14, 2022; Published: January 31, 2022


Purpose: To describe our experience of bilateral sudden vision loss in a rare autosomal recessive (AR) platelet aggregation disorder, that is Glanzmann´s thrombasthenia (GT).

Observation: We report nonarteritic anterior ischemic optic neuropathy (AION) as a cause, following severe attack of gynecological bleeding in a 15-years-old girl. She had recurrent attacks of blood loss and subsequent hypovolemia requiring blood transfusion. This form of optic neuropathy is diagnosed due to the presence of bilateral pale swollen optic discs and proved by altitudinal pattern of perimetry along with exclusion of other reasons and normal visual evoked potential.

Conclusion: Nonarteritic AION should be considered in young patients diagnosed with bleeding disorders, whenever vision loss is preceded by hypovolemia. Reversibility of vision loss is possible

Keywords: Blood Loss; Hypovolemia; Glanzmann; Anterior Ischemic Optic Neuropathy; Case Report


  1. George JN., et al. “Glanzmann’s thrombasthenia: the spectrum of clinical disease”. Blood7 (1990): 1383-1395.
  2. Fiore M., et al. “Clinical utility gene card for: Glanzmann thrombasthenia”. European Journal of Human Genetics 10 (2012): 1101.
  3. Nurden AT. “Glanzmann thrombasthenia”. Orphanet Journal of Rare Diseases 1 (2006): 1-8.
  4. Sebastiano C., et al. “Glanzmann’s thrombasthenia: report of a case and review of the literature”. International Journal of Clinical and Experimental Pathology 4 (2010): 443-447.
  5. Caen JP. “5 Glanzmann’s thrombasthenia”. Baillière's Clinical Haematology 3 (1989): 609-625.
  6. Salomon O., et al. “Analysis of prothrombotic and vascular risk factors in patients with nonarteritic anterior ischemic optic neuropathy”. Ophthalmology 4 (1999): 739-742.
  7. Buono LM and Foroozan R. “Perioperative posterior ischemic optic neuropathy: review of the literature”. Survey of Ophthalmology 1 (2005): 15-26.
  8. Hayreh SS. “Anterior ischemic optic neuropathy. VIII. Clinical features and pathogenesis of post-hemorrhagic amaurosis”. Ophthalmology 11 (1987): 1488-1502.
  9. , et al. “Non-arteritic anterior ischaemic optic neuropathy secondary to menorrhagia in a young healthy woman”. BMJ Case Reports 2018 (2018): bcr2018225113.
  10. Stoffelns BM. “Anterior ischemic optic neuropathy due to abdominal hemorrhage after laparotomy for uterine myoma”. Archives of Gynecology and Obstetrics 1 (2010): 157-160.
  11. Chutorian AM., et al. “Anterior ischemic optic neuropathy in children: case reports and review of the literature”. Pediatric Neurology 26 (2002): 358-364.
  12. Hayreh SS and Zimmerman B. “Visual field abnormalities in nonarteritic anterior ischemic optic neuropathy: Their pattern and prevalence at initial examination”. Archives of Ophthalmology 11 (2005): 1554-1562.
  13. Desai N., et al. “Nonarteritic anterior ischemic optic neuropathy”. The Journal of Clinical Hypertension (Greenwich)2 (2005): 130-133.

Citation: Mohammad A Rashad., et al. “Bilateral Nonarteritic Anterior Ischemic Optic Neuropathy in a Glanzmann Disease". Acta Scientific Clinical Case Reports 3.2 (2022): 76-80.

Copyright: © 2022 Mohammad A Rashad., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is May 20, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US