COVID-19 and Black Fungus: New Insights Explaining the Pathogenicity of the Disease
Ahed J Alkhatib1,2*
1Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology, Jordan
2International Mariinskaya Academy, Department of Medicine and Critical Care, Department of Philosophy, Academician Secretary of Department of Sociology, Jordan
*Corresponding Author: Ahed J Alkhatib, Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology, Jordan.
Received: June 30, 2021; Published: July 21, 2021
The latest outbreak of COVID-19 has been associated with black fungus. In this study, the author reviewed the literature regarding the black fungus and its coexistence with COVID-19. Literature indicated several risk factors such as being diabetic and immunocompromised. We added our new insights to the pathogenesis of fungi through the results of our previous studies in which we demonstrated that fungi express estrogen receptor, BCL2 protein, and p53. These biomarkers imply that fungi benefit from the microenvironment if estrogen exists. However, if patients under steroid treatments, they are likely to develop secondary infections such as black fungus.
Keywords: Black Fungus; COVID-19; p53; BCL2; Estrogen Receptor
- KR Kumar P. “Mucormycosis: A Black Fungus- Post Covid Complications”. Journal of Regenerative Biology and Medicine4 (2021): 1-8.
- Gangneux JP., et al. “Invasive fungal diseases during COVID-19: we should be prepared”. Journal of Medical Mycology2 (2020): 100971.
- Guo L., et al. “Clinical features predicting mortality risk in patients with viral pneumonia: the MuLBSTA score”. Frontiers in Microbiology 10 (2019): 2752.
- Gostinˇcar C., et al. “Polyextremotolerant black fungi: Oligotrophism, adaptive potential, and a link to lichen symbioses”. Frontiers in Microbiology 3 (2012): 390.
- Cordero RJB., et al. “Microbial melanins for radioprotection and bioremediation”. Microbial Biotechnology 10 (2017): 1186-1190.
- Hernández JL and Buckley CJ. “Mucormycosis”. 2020 Jun 26. In: StatPear (2021).
- https://www.cdc.gov/fungal/diseases/mucormycosis/symptoms.html
- https://www.cdc.gov/fungal/diseases/mucormycosis/causes.html
- Reid G., et al. “Mucormycosis”. Seminars in Respiratory and Critical Care Medicine 1 (2020): 99-114.
- https://www.cdc.gov/fungal/diseases/mucormycosis/definition.html
- Spellberg B., et al. “Novel perspectives on mucormycosis: pathophysiology, presentation, and management”. Clinical Microbiology Reviews 3 (2005): 556-569.
- Dyer O. “Covid-19: India sees record deaths as "black fungus" spreads fear”. British Medical Journal on JSTOR 373 (2021): n1238.
- https://www.indiatoday.in/coronavirus-outbreak/story/rajasthan-declares-black-fungus-an-epidemic-cases-pile-up-in-several-states-10-points-1804470-2021-05-19
- Sen M., et al. “COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19”. Indian Journal of Ophthalmology 3 (2021): 488-509.
- Garg D., et al. “Coronavirus Disease (Covid-19) Associated Mucormycosis (CAM): Case Report and Systematic Review of Literature”. Mycopathologia2 (2021): 289-298.
- https://www.medyblog.com/post/mucormycosis-in-post-covid-patients
- Ahed J Alkhatib. “The Expression of Estrogen Receptor and Bcl2 in Candida albicans May Represent Removal of Functional Barriers among Eukaryotic and Prokaryotic Cells”. EC Microbiology01 (2017): 20-23.
- G Al-Saghir M., et al. “Immunohistochemical Localization of Aspergillus and p53 in Human Lung Tissues”. American Journal of Molecular Biology 5 (2015): 117-123.