Acta Scientific Clinical Case Reports

Case ReportVolume 2 Issue 6

A Good History Can Unlock Puzzle- A Case Report of Ibuprofen Induced Minimal Change Glomerulonephritis

Anusha Yanamadala* and Parikshit Thakur Hameer

Presbyterian Plains Regional Medical Center; Clovis, NM, USA

*Corresponding Author: Anusha Yanamadala, Presbyterian Plains Regional Medical Center; Clovis, NM, USA.

Received: April 15, 2021; Published: June 02, 2021

Citation: Anusha Yanamadala and Parikshit Thakur Hameer. “A Good History Can Unlock Puzzle- A Case Report of Ibuprofen Induced Minimal Change Glomerulonephritis". Acta Scientific Clinical Case Reports 2.7 (2021): 21-22.

Abstract

Minimal-change disease (MCD) is uncommon in adults contributing about 10% of nephrotic syndrome cases in adults. Underlying pathology is thought to be due to T-cell or B- cell dysfunction resulting in circulating factors like IL-13 affecting glomerular capillary wall permeability resulting in significant proteinuria. NSAIDs (Nonsteroidal anti-inflammatory drugs) are common cause for secondary MCD but often underdiagnosed with missing information from history. Untreated MCD were associated with a high risk for thromboembolism and mortality. We are presenting a case report of ibuprofen induced minimal change glomerulonephritis in a young patient who took ibuprofen on a regular basis with a history of fracture for pain management without subsequent monitoring and unaware of significant side effects of medication.

 

Keywords: Ibuprofen; Glomerulonephritis; Minimal-Change Disease (MCD)

Bibliography

  1. Lai KW., et al. “Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats”. Journal of the American Society of Nephrology 5 (2007): 1476-1485.
  2. Tune BM and Mendoza SA. “Treatment of the idiopathic nephrotic syndrome: regimens and outcomes in children and adults”. Journal of the American Society of Nephrology 5 (1997): 824-832.

Copyright: © 2021 Anusha Yanamadala and Parikshit Thakur Hameer. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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