Acta Scientific Cancer Biology (ASCB)

Review ArticleVolume 9 Issue 1

The Connection Between Sarcopenia and Trismus and Their Impact on Survival Outcomes in Curatively Treated Head and Neck Cancer Patients

Efsun Somay1*, Erkan Topkan2, Nilüfer Kılıç Durankus3, Sibel Bascil4 and Ugur Selek3

1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Baskent University, Ankara, Turkey
2Department of Radiation Oncology, School of Medicine, Baskent University, Adana, Turkey
3Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey
4Department of Periodontology, Faculty of Dentistry, Baskent University, Ankara, Turkey

*Corresponding Author: Efsun Somay, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Baskent University, Ankara, Turkey

Received: February 04, 2025; Published: February 21, 2025

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Head and neck cancers (HNCs) rank as the ninth most prevalent malignancy on a global scale. These cancers encompass various malignancies from different anatomical sites, including the oral cavity, pharynx, larynx, and paranasal sinuses. Despite significant advancements in treatment methodologies, HNCs continue to represent a critical public health challenge due to their high morbidity and mortality rates. Sarcopenia, characterized by a progressive decline in skeletal muscle mass, strength, and contraction capacity, has emerged as a critical factor influencing the prognosis of individuals diagnosed with HNC. The prevalence of sarcopenia among this patient population ranges from 35.5% to 54.5%. Sarcopenia is increasingly recognized for its association with greater treatment intolerance, reduced survival rates, and diminished quality of life in patients with HNC. Trismus, characterized by a restricted ability to open the mouth, frequently manifests as a long-term complication in patients undergoing treatment for HNC. This condition has the potential to trigger or exacerbate the nutritional and functional challenges associated with sarcopenia. Conversely, sarcopenia can also significantly contribute to the onset or worsening of trismus, primarily due to associated muscle loss and weakness. Sarcopenia and trismus likely have a reciprocal relationship, significantly influencing one another and impacting survival outcomes in patients with HNC. Hence, this review seeks to clarify the intricate relationships between sarcopenia and trismus, and how these conditions influence the survival outcomes of HNCs.

Keywords: Sarcopenia; Trismus; Survival; Head and Neck Cancer

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Citation

Citation: Efsun Somay., et al. “The Connection Between Sarcopenia and Trismus and Their Impact on Survival Outcomes in Curatively Treated Head and Neck Cancer Patients”.Acta Scientific Cancer Biology 9.1 (2025): 02-11.




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Acceptance rate35%
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Impact Factor1.183

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