Acta Scientific Cancer Biology (ASCB)

Research Article Volume 8 Issue 6

Atypical Histologic Features Associated with Metastasis in Blue Naevi

Paul H Hartel1,2*

1Sligo University Hospital, Ireland
2West Virginia University School of Medicine, Ireland

*Corresponding Author: Paul H Hartel, Professor, Sligo University Hospital, Ireland.

Received: May 20, 2024; Published: May 30, 2024


Atypical blue naevus is a controversial entity with histologic features that can be similar to both benign blue naevi and melanoma. Evaluated were 30 blue naevi for atypical histologic features that conventionally include increased lesion size, increased cellularity, polymorphous spindle and epithelioid cells, vesicular nuclei and prominent nucleoli, intense pigmentation, and infiltrative growth with ‘dumbell’-shaped nesting. It was found that when present together, atypical histologic features of fatty infiltration, polymorphous population of spindle and epithelioid cells with prominent nucleoli, perineural infiltration and deep ‘dumbell-shaped’ lesional cell nesting were associated with sentinel lymph node metastasis. In select cases, these histologic features, when present together, may impart higher clinical risk and may warrant adequate complete lesional excision and sentinel lymph node sampling.

Keywords: Atypical Blue Naevus; Cellular Blue Naevus; Malignant Melanoma; Sentinel Lymph Node Metastasis



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Citation: Paul H Hartel., et al. “Atypical Histologic Features Associated with Metastasis in Blue Naevi”.Acta Scientific Cancer Biology 8.6 (2024): 26-28.


Acceptance rate35%
Acceptance to publication20-30 days
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