Acta Scientific Cancer Biology (ASCB)

Research Article Volume 7 Issue 9

Trend of Cancer in Young Adults

Seema Devi1*, Rajesh Kumar Singh2, Abhishek Kumar3, Raina Rana4 and Aman Prakash5

1Additional Professor, Department of Radiation Oncology, IGIMS, Patna, India
2Professor, Department of Radiation Oncology, IGIMS, Patna, India
3PG 3rd Year, Department of Radiation Oncology, IGIMS, Patna, India
4PG 2nd Year, Department of Radiation Oncology, IGIMS, Patna, India
5Statistian, IGIMS, Patna, India

*Corresponding Author: Seema Devi, Additional Professor, Department of Radiation Oncology, IGIMS, Patna, India.

Received: September 29, 2023; Published: October 24, 2023

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Introduction: National cancer Institute has given the definition of young adult cancer in which diagnosis occurs between the age of 15 and 39 years. (1) Cancer with AYA have high risk of long-term effect of cancer and its treatment like organ dysfunction, infertility and secondary cancers as compared to older group of cancer patients (6,7,8) cancer is more common in elderly group according to some studies. Several Studies shown increasing evidence in younger population.

Result: We have analyzed the data from 2014 to 2021. Total 4667 (20.11%) Cases were registered, 3410 (52.89%) were males and 3037 (47.1%) were females. We analyzed 15 common cancers in our study in which 4698 (14.65%) cases were registered, commonest cancer we found in this group from 20-39 years was carcinoma breast with 18.88%. 2nd commonest was Head and Neck cancer with 14.32% of the cases.

Discussion: Urban Population based registry of India shown 5.8% of incidence with younger adults, same rate of incidence also reported in England (13), other studies reported prevalence rate from 3.8 to 5.71% (15). Breast cancer is commonest cancer affecting females worldwide about 25.4% of all new cases diagnosed in a year, it is reported the major cause of the death in 103 countries including India (28) 1%-2% cases of breast cancer reported under 35 years of age globally (1) Breast cancer in young population reported higher histological grades, higher death rate, unfavorable hormonal status (29).

Conclusion: 20-39 years have different epidemiological, biological, genetic factors. Carcinoma Breast (19%) was commonest cancer in our study. 2nd commonest was Hematolymphoid (14.4%). .

Keywords: Breast Cancer; Carcinoma Breast; Carcinoma Gall Bladder

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References

  1. US Department of Health and Human Services. Closing the gap: research and care imperatives for adolescents and young adults with cancer: Report of the Adolescent and Young Adult Oncology Progress Review Group. NIH publication (2006): 2-3.
  2. Miller KD., et al. “Cancer statistics for adolescents and young adults, 2020”. CA Cancer Clinics6 (2020): 443-459.
  3. Trama A., et al. “Cancer burden in adolescents and young adults: a review of epidemiological evidence”. Cancer 6 (2018): 256-266.
  4. Chao C., et al. “Incidence, risk factors, and mortality associated with second malignant neoplasms among survivors of adolescent and young adult cancer”. JAMA Network Open 2 (2019): e:195536.
  5. Bleyer A., et al. “The distinctive biology of cancer in adolescents and young adults”. Nature Reviews Cancer 8 (2008): 288-298.
  6. Bright CJ., et al. “Risk of subsequent primary neoplasms in survivors of adolescent and young adult cancer (Teenage and Young Adult Cancer Survivor Study): a population-based, cohort study”. Lancet Oncology 20.4 (2019): 531-545.
  7. Jim HSL., et al. “Cognition in adolescent and young adults diagnosed with cancers an understudied problem”. Clinical Oncology27 (2018): 2752-2754.
  8. Adams SC., et al. “Young adult cancer survivorship: recommendations for patient follow-up. exercise therapy, and research”. NCI Cancer Spectrum 1 (2020): pkaa099.
  9. Adam R., et al. “Do patients' faces influence General Practitioners' cancer suspicions? A test of automatic processing of sociodemographic information”. PLoS ONE 12 (2017): 0188222.
  10. Magrath I and Epelman S. “Cancer in adolescents and young adults in countries with limited resources”. Our Oncology Report 15 (2013): 332-346.
  11. Siegel RL., et al. “Global patterns and trends in colorectal cancer incidence in young adults”. Gut 68 (2019): 2179-2185.
  12. Sung H., et al. “Emerging cancer trends among young adults in the USA: analysis of a population-based cancer registry”. Lancet Public Health 4 (2019): 137-147.
  13. Arora RS., et al. “Cancer at ages 15-29 years: the contrasting incidence in India and England”. Pediatric Blood Cancer1 (2012): 55-60.
  14. Moon EK., et al. “Cancer incidence and survival among adolescents and young adults in Korea”. PLoS One5 (2014): 96088.
  15. Sharma D and Singh G. “Spectrum of cancer in adolescents and young adult: an epidemiological and clinicopathological evaluation”. Indian Cancer 53 (2016): 457-459.
  16. Bleyer A. “How NCCN guidelines can help young adults and older adolescents with cancer and the professionals who care for them”. JNCCN 9 (2012): 1065-1071.
  17. Barr RD., et al. “US National Cancer Institute Science of Adolescent and Young Adult Oncology Epidemiology Working Group. Incidence and incidence trends of the most frequent cancers in adolescent and young adult Americans, including "nonmalignant/noninvasive* tumors”. Cancer071 (2016): 1000-1008.
  18. Roder DM., et al. “Australian adolescents and young adults-trends in cancer incidence, mortality, and survival over three decades”. Journal of Adolescent and Young Adult Oncology 3 (2018): 326-338.
  19. Gupta N., et al. “Epidemiology of cancer in young in central India: an analysis of rural cancer hospital data”. South Asian Journal of Cancer4 (2017): 183-185.
  20. Qureshi MA., et al. “Common cancers in Karachi, Pakistan: 2010-2019 cancer data from the Dow Cancer Registry”. Pakistan Journal of Medical Sciences 36 (2020): 1572-1578.
  21. Manzoor S., et al. “Presentation, diagnosis and management of locally advanced breast cancer: Is it different in low /middle income countries?”. Pakistan Journal of Medical Sciences 35 (2019): 1554-1557.
  22. Oluogun WA., et al. “Histological classification, grading, staging, and prognostic indexing of female breast cancer in an African population: a 10-year retrospective study”. International Health Science (Qassim). 13 (2019): 3-9.
  23. Johnson RH., et al. “Breast cancer in adolescents and young adults”. Pediatric Blood Cancer 65 (2018): e23797.
  24. Anastasiadi Z., et al. “Breast cancer in young women: an overview”. Updates Surgery 69 (2017): 313-317.
  25. Rossi L., et al. “Diagnosis and treatment of breast cancer in young women”. Current Treatment Options in Oncology 20 (2019): 86.
  26. Gabriel CA and Domchek SM. “Breast cancer in young women”. Breast Cancer Research 12 (2010): 212.
  27. Carraso DM., et al. “Comprehensive analysis of BRCA1. BRCA2 and TP53 germline mutation and tumor characterisation: a portrait of early -onset breast cancer in Brazil”. Plos One 8 (2013): 657581.
  28. Sung H., et al. “Global Cancer Statistics 2020. GLOBOCAN Estimates of Incidence and Mortality Worldwide For 36 Cancers in 185 Countries”. CA: A Cancer Journal for Clinicians 71 (2021): 209-249.
  29. Martinez MT., et al. “Breast cancer in very young patients in a Spanish cohort: age as an independent Dad prognostic indicator”. Breast Cancer: Basic Clinical Research 13 (2019): 1-10.
  30. Varughese AA., et al. “Descriptive study on selected risk factors and histopathology of breast carcinoma in a tertiary care centre in Kerala, India with special reference to women under 40 years old”. The Asian Pacific Journal of Cancer Prevention 16 (2019): 181-184.
  31. Gogia A., et al. “Young breast cancer: A single centre experience”. Indian Journal of Cancer 51 (2014): 604-608.
  32. Takalkar UV., et al. “Clinicopathological profile of breast cancer patients at a tertiary care hospital in marathwada region of Westen India”. The Asian Pacific Journal of Cancer Prevention 17 (2016): 2195- 2198.
  33. Parmar V. “Rising Incidence of Breast Cancer in the Young Fertile Indian Population-a Reality Check”. Indian Journal of Surgical Oncology 9 (2018): 296-299.
  34. Deshmukh SP., et al. “Breast cancer in young women in India”. Annals of Oncology 23 (2012): 101.
  35. Ghosh S., et al. “Clinico-morphological profile and receptor status in breast cancer patients in a South Indian institution”. The Asian Pacific Journal of Cancer Prevention 15 (2014): 7839-7842.
  36. Bleyer A., et al. National Cancer Institute, NIH Pub. No 06-5767; 2006 Cancer Epidemiology in Older Adolescents and Young Adults 15-29 Years of Age, Including SEER Incidence and Survival: 1975-2000.
  37. Padhye B., et al. “Patterns of malignancies in adolescents and young adults in tertiary care center from developing country”. Implication for outcome optimization and health service SIOP Abstract book (2006): 479-480.
  38. Mohanti BK., et al. “Young patients with breast cancer (<35 years): Single-institution study of 194 patients from India”. Journal of Clinical Oncology (2012): e11013.
  39. Raina V., et al. “Breast cancer in the young (=35 years): A single centre study from the All India Institute of Medical Sciences”. Journal of Clinical Oncology (2013): e12539.
  40. Howlader NN., et al. “Cancer Statistics Review (CSR) 1975-2014”. Cancer Stat Re….2020……
  41. Sung H., et al. “Emerging cancer trends among young adults in the USA: analysis of a population-based cancer registry”. Lancet Public Health 4 (2019): e137-e147.
  42. Adolescent and Young Adult Oncology Progres Review Group: Closing the gap: research and care imperatives for adolescents and young adults with cancer (2021).
  43. Arnold M., et al. “Global Burden 5 Major Types of Gastrointestinal Cancer”. Gastroenterology 159 (2020): 335-349. e15.
  44. Aben KK., et al. “Cancer in adolescents and young adults (15-29 years): a population-based study in the Netherlands 1989-2009”. Acta Oncology7 (2012): 922-933.
  45. Haggar FA., et al. “Cancer incidence and mortality trends in Australian adolescents and young adults, 1982-2007”. BMC Cancer 12 (2012): 151.
  46. Gamble LA., et al. “Hereditary Diffuse Gastric Cancer Syndrome and the Role of CDH1: A Review”. JAMA Surgery 156 (2021): 387-392.
  47. Valle L., et al. “Genetic predisposition to colorectal cancer: syndromes, genes, classification of genetic variants and implications for precision medicine”. Journal of Pathology 247 (2019): 574-588.
  48. Fidler MM., et al. “A global view on cancer incidence and national levels of the human development index”. International Journal of Cancer 139 (2016): 2436-2446.
  49. Li J. “Digestive cancer incidence and mortality among young adults worldwide in 2020: A population-based study”. World J Gastrointest Oncol. 14.1 (2022): 278-294.
  50. National Comprehensive Cancer Network. The NCCN adolescent and young adult (AYA) oncology clinical guidelines (version 1, 2021).
  51. Sikora SS., et al. “Palliative surgical treatment of malignant obstructive jaundice”. Eur J Surg Oncol 1994;20:580-4.
  52. Kapoor VK., et al. “Early carcinoma of the gallbladder. An elusive disease”. J Surg Oncol 62 (1996): 284-287.
  53. Sharma B. “Deserprive pidemiology of inesdence and mortaliy of primary liver cancer in 185 countries: evidence from GLOBOCAN 2018”. Jpn Journal of Clinical Oncology 50 (2020): 1370-1379.
  54. Chang HS., et al. “Comparing endoscopy and upper gastrointestinal X-ray for gastric cancer screening in South Korea: a cost-utility analysis”. The Asian Pacific Journal of Cancer Prevention 13 (2012): 2721- 2728.
  55. Howson CP., et al. “The decline in gastric cancer: epidemiology of an unplanned triumph”. Epidemiology Review 8 (1986): 1-27.
  56. Conti L., et al. “Revisiting the impact of lifestyle on colorectal cancer risk in a gender perspective”. Critical Reviews in Oncology/Hematology 145 (2020): 102834.
  57. Plummer M., et al. “Global burden of gastric cancer attributable to Helicobacter pylori”. International Journal of Cancer 136 (2015): 487-490.
  58. Arnold M., et al. “Recent trends in incidence of five common cancers in 26 European countries since 1988: Analysis of the European Cancer Observatory”. European Journal of Cancer 51 (2015): 1164-1187.
  59. Fidler MM., et al. “Cancer incidence and mortality among young adults aged 20-39 years worldwide in 2012: a population-based study”. Lancet Oncology12 (2017): 1579-1589.
  60. Iype EM., et al. “Oral cancer among patients under the age of 35 years”. Journal of Postgraduate Medicine 3 (2001): 171-176.
  61. Carniol PJ and Fried MP. “Head and neck carcinoma in patients under 40 years of age”. The Annals of Otology, Rhinology and Laryngology 91 (1982): 152-155.
  62. Byers RM. “Squamous cell carcinoma of the oral tongue in patients less than 30 years of age”. American Journal of Surgery 130 (1975): 475-478.
  63. Venables CW and Craft IL. “Carcinoma of the tongue in early adult life”. British Journal of Cancer 21 (1967): 645-650.
  64. Son YH and Kapp DS. “Oral cavity and oropharyngeal cancer in a younger population”. Cancer 55 (1985): 441-444.
  65. Kuriakose M., et al. “Comparison of oral squamous ell carcinoma in younger and older patients in india”. European Journal of Cancer Part B: Oral Oncology 28 (1992): 113-120.
  66. Gupta PC. “Mouth cancer in India: A new epidemic?” Journal of Indian Medical Association 97 (1999): 370-373.
  67. Llewellyn CD., et al. “Risk factors for squamous cell carcinoma of the oral cavity in young people A comprehensive literature review”. Oral Oncology 37 (2001): 401-418.
  68. Llewellyn CD., et al. “Squamous cell carcinoma of the oral cavity in patients aged 45 years and under: A descriptive analysis of 116 cases diagnosed in the south East of England from 1990 to 1997”. Oral Oncology 39 (2003): 106-114.
  69. Llewellyn CD., et al. “Squamous cell carcinoma of the oral cavity in patients aged 45 years and under: A descriptive analysis of 116 cases diagnosed in the South East of England from 1990 to 1997”. Oral Oncology 39 (2003): 106-114.
  70. Toner MO and Regan EM. “Head and neck squamous cell carcinoma in the young: A spectrum or a distinct group? Part1”. Head and Neck Pathology 3 (2009): 246-248.
  71. Jemal A., et al. “Cancer statistics, 2007”. CA: A Cancer Journal for Clinicians 57 (2007): 43-66.
  72. Boyle P and Levin B. “World Cancer Report”. International Agency for Research on Cancer, (2008).
  73. Ragin CC., et al. “The epidemiology and risk factors of head and neck cancer. A focus on human papillomavirus”. Journal of Dental Research 86 (2007): 104-114.
  74. Kreimer AR., et al. “Human papillomavirus types in head and neck squamous cell carcinomas worldwide: A systematic review”. Cancer Epidemiology, Biomarkers and Prevention 14 (2005): 467-475.
  75. Sturgis EM., et al. “Descriptive epidemiology and risk factors for head and neck cancer”. Seminar on Oncology 31 (2004): 726-733.
  76. Stepanov I., et al. “New and traditional smokeless tobacco: Comparison of toxicant and carcinogen levels”. Nicotine Tob Research 10 (2008): 1773-1782.
  77. Mondal R and Ghosh SK. “Accumulation of mutations over the complete mitochondrial genome in tobacco-related oral cancer trom Northeast India”. Mitochondri31 DNA 24 (2013): 432-439.
  78. Schantz SP and Yu GP. “Head and neck cancer incidence trends in young Americans, 1973-1997, with a special analysis for tongue cancer”. Archives of Otorhinolaryngology-Head and Neck Surgery 128 (2002): 268-274.
  79. Sturgis EM and Wei Q. “Genetic susceptibility-Molecular epidemiology of head and neck cancer”. Current Opinion on Oncology 14 (2002): 310-317.
  80. Llewellyn CD., et al. “Risk Factors for oral cancer in newly diagnosed patients aged 45 years and younger: A case-control study in Southern England”. Journal of Oral Pathology and Medicine 33 (2004): 525.32.
  81. Sturgis EM., et al. “Descriptive epidemiology and risk factors for head and neck cancer”. Seminar on Oncology 31 (2004): 726-733.
  82. Dahlstorm KR., et al. “Squamous cell carcinoma of the head and neck in never smoker-never drinkers: A descriptive epidemiologic study”. Head and Neck 30 (2008): 75-84.
  83. Kulkarni MK. “Head and neck cancer burden in india”. International Journal of Head and Neck Surgery 4 (2013): 29-35.
  84. Sharma JD., et al. “Head and neck squamous cell carcinoma in young adults: A hospital-based study”. Indian Journal of Medical and Paediatric Oncology 40 (2019): S18-22.
  85. Gawecki W., et al. “Clinical and histopathological analysis of squamous cell carcinoma of the head and neck in young adults”. Otolaryngologia polska 61 (2007): 11-16.
  86. Schultz KA., et al. “Pediatric ovarian tumors: a review of 67 cases”. Pediatric Blood Cancer 44 (2005): 167-173.
  87. Koulouris CR and Penson RT. “Ovarian stromal and germ cell tumors”. Seminar on Oncology 36 (2009): 12636.
  88. Shanbhogue AK., et al. “Clinical syndromes associated with ovarian neoplasms: a comprehensive review”. RadioGraphics 30 (2010): 903-919.
  89. Smyczek-Gargya B and Geppert M. “Endometrial cancer associated with polycystic ovaries in young women”. Pathology - Research and Practice 188 (1992): 946-948.
  90. di Martino E., et al. “Incidence trends for twelve cancers in younger adults—a rapid review”. British Journal of Cancer 126 (2022): 1374-1386.
  91. Fan X., et al. “China: Advances, challenges and visions”. Chinese Journal of Cancer Research (2021).
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Citation

Citation: Oeema Devi., et al. “Trend of Cancer in Young Adults”.Acta Scientific Cancer Biology 7.9 (2023): 29-39.




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