Kulvinder Kochar Kaur¹*, Gautam Allahbadia² and Mandeep Singh³

¹Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
²Scientific Director, Rotunda-A Centre for Human Reproduction, Mumbai, India
³Consultant Neurologist, Swami Satyan and Hospital, Jalandhar, Punjab, India

*Corresponding Author: Kulvinder Kochar Kaur, Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India.

Received: July 14, 2023; Published: July 25, 2023

Abstract

It has been reasoned out that induction of greater quantities of Reactive oxygen (ROS) with in the tumor cells is a cancer treatment strategy known as Chemodynamic therapy (CDT). Depending on the administration of Fenton reaction facilitators like Fe²⁺, CDT benefits from the fact that over generated ROS amongst the tumor microenvironment. Production of a peptides- H2S donor conjugate (PHDC) which was complexed with Fe²⁺ known as AAN-PTC- Fe²⁺ was achieved by Zhu., et al. This AAN-tripeptide was particularly cleaved by legumain, an enzyme which was over expressed in glioma cells for liberation of carbonyl Sulfide (COS). Whereas COS hydrolysis by enzyme carbonic anhydrase (CA) which generated H2S, a hampering agent of catalase (CAT), an enzyme which leads to detoxification of H2O2. Fe²⁺ in combination with H2S escalated intracellular ROS quantities as well as diminished viability in C6 glioma cells in contrast to controls having absence of either Fe²⁺, AAN sequence or capacity of production of H2S. AAN-PTC- Fe²⁺ worked better compared to temozolomide whereas demonstrating no cytotoxicity against cardiomyocytes. Hence this study illustrated an H2S-augmented, enzyme responding manifesto regarding synergistic cancer treatment.

 Keywords: H2S donor; Reactive Oxygen;

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Citation

Citation: Kulvinder Kochar Kaur., et al. “Advances in Glioma Treatment with Utilization of Enzyme - Stimulated Chemodynamic Therapy - Through a Peptides - H2S Donor Conjugate Complexed with Fe²⁺ -- A Short Communication" Acta Scientific Cancer Biology 7.6 (2023): 22-25.

Copyright

Copyright: © 2023 Kulvinder Kochar Kaur., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.