Acta Scientific Cancer Biology (ASCB) (ISSN: 2582-4473)

Case Report Volume 7 Issue 5

Intense Splenic 99mTc-MDP Uptake in Patient with Langerhans Cell Histiocytosis

Pandey Shailesh, Mandal Sandip Kumar, Gnawali Suman, Sharma Nitu, Adhikari Ganga D and Yadav Ajay Kumar*

Department of Radio-Diagnosis, Imaging and Nuclear Medicine, BP Koirala Memorial Cancer Hospital, Bharatpur, Nepal

*Corresponding Author: Yadav Ajay Kumar, Department of Radio-Diagnosis, Imaging and Nuclear Medicine, BP Koirala Memorial Cancer Hospital, Bharatpur, Nepal.

Received: July 09, 2021; Published: June 29, 2023


Uptake of 99mTc-MDP (methylene diphosphonate) in spleen is very rare in 99mTc-MDP bone scintigraphy scan. We encountered a 14-year-old child patient with Langerhans Cell Histiocytosis was examined by 99mTc-MDP bone scintigraphy. There was intense uptake of tracer in spleen. The patient was treating with chemotherapy and 4 cycles of chemotherapy were completed. Ultrasonography report revealed that there was mild spleenomegaly. Bone scintigraphy showed intense and diffuse MDP accumulation in the enlarged spleen without ultrasonographic or radiologic evidence of calcification. We never seen intense splenic 99mTc-MDP accumulation in patient with Langerhans Cell Histiocytosis in any case report or any other literatures.

 Keywords: 99mTc-MDP; Splenic Uptake; Langerhans Cell Histiocytosis


  1. Kaur H., et al. “Spleen Uptake on a Bone Scan”. Journal of Nuclear Medicine Technology3 (2017): 245-246.
  2. Shi X., et al. “Diffuse hepatic and splenic uptake of Tc-99m methylene diphosphonate on bone scintigraphy after intravenous administration of gadolinium-containing MRI contrast”. Clinical Nuclear Medicine 3 (2011): 178-182.
  3. De Marini Pierre MD., et al. “Spleen Uptake on Bone Scan After Frequent Platelet and RBC Transfusions”. Clinical Nuclear Medicine10 (2016): 802-803.
  4. Yapar AF., et al. “Diffuse splenic Tc-99m MDP uptake in hypersplenic patient”. Annals of Nuclear Medicine8 (2004): 703-705.


Citation: Yadav Ajay Kumar., et al. “Intense Splenic 99mTc-MDP Uptake in Patient with Langerhans Cell Histiocytosis" Acta Scientific Cancer Biology 7.5 (2023): 12-14.


Copyright: © 2023 Yadav Ajay Kumar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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