Acta Scientific Cancer Biology (ASCB) (ISSN: 2582-4473)

Review Article Volume 7 Issue 4

The Effects of β-Endorphin, the Autonomic Nervous System and the Environment on Suppressing the Growth and Progression of Malignant Tumors (Cancers)

Satoru Mihara*

Nishinippori 2-10-12, Arakawa-ku, Tokyo, Japan

*Corresponding Author: Satoru Mihara, Nishinippori 2-10-12, Arakawa-ku, Tokyo, Japan.

Received: May 18, 2023; Published: May 31, 2023

Abstract

Transplantations of β-endorphin neurons into the hypothalamus in rats suppress the growth and progression of cancers in various tissues and prevent the metastasis of tumors via the suppression of the sympathetic nervous system and the activation of the parasympathetic nervous system. A fragrant environment containing a low concentration of α-pinene induces a significant increase in the parasympathetic nervous activity in young adult females, and long-term exposure to that suppresses melanoma growth in mice. Long-term exposure to low concentrations of a homologous series of aliphatic alcohols, phenols, ketones, and their derivatives generally enhance the hypothalamic β-endorphin levels in rats. The enriched environment induces suppression of the sympathetic nervous system and/or activation of the parasympathetic nervous system through decreased leptin expression and secretion as well as releasing β-endorphin and show a suppression of tumor growth in mice.

Moderate-intensity physical activity results in tumor suppression, at least in part through the actions of hypothalamic β-endorphin, which is responsible for a physical effect known as a runner's high.

 Keywords: Tumor; Cancer; Enriched Environment; Odor; Autonomic; β-endorphin; Physical Activity

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Citation

Citation: Satoru Mihara. “The Effects of β-Endorphin, the Autonomic Nervous System and the Environment on Suppressing the Growth and Progression of Malignant Tumors (Cancers)" Acta Scientific Cancer Biology 7.4 (2023): 25-35.

Copyright

Copyright: © 2023 Satoru Mihara. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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