Acta Scientific Cancer Biology (ASCB) (ISSN: 2582-4473)

Case Report Volume 7 Issue 3

Extramedullary Plasmacytoma Maxilla - A Case Report

Seema Devi1*, Abhishek Kumar2 and Raina Rana3

1Additional Professor, Department of Radiation Oncology, IGIMS, Patna, India
2PG 3rd Year, Department of Radiation Oncology, IGIMS, Patna, India
3PG 2nd Year, Department of Radiation Oncology, IGIMS, Patna, India

*Corresponding Author: Seema Devi, Additional Professor, Department of Radiation Oncology, IGIMS, Patna, Bihar, India.

Received: April 12, 2023; Published: April 26, 2023


Plasma cells are normally found in Bone Marrow, it is responsible for Immunity response by making antibodies to fight infections. A localised buildup of abnormal plasma cells either inside the bone or outside the bones causes Solitary plasmacytoma [1]. Solitary bone plasmacytoma is a rare malignancy in head and neck region.

 It usually occurs in adult male with average age of diagnosis. A 49 year old presented in our outdoor patient department with complain of pain and swelling in Left Maxillary area for last one months. Bone Marrow Biopsy shown Mildly hypercellular marrow spaces with granulocyte hyperplasia. Megakaryocyte and erythroid series of cells are proportionally rated.

Biopsy from local area shown poorly differentiated malignant neoplasm. CECT-FACE findings were a large enhancing necrotic mass lesion, PET Scan report shows tumour invades the anterior wall to involve the pre- maxillary soft tissue.

Presence of an Isolated region of Bony destruction due to clonal plasma cells with morphological normal bone marrow examination with very low clonal plasma cell infiltration <10% are diagnosed criteria of solitary plasmacytoma other criteria are normal kidney function, occurrence of anaemia and hypercalcemia lower serum or urine level of monoclonal antibodies [7].

 Keywords: Solitary Plasmacytoma; Malignant Neoplasm; Extramedullary Plasmacytoma


  1. Nofsinger YC., et al. “Head and neck manifestations of plasma cell neoplasms”. Laryngoscope 107 (1997): 741-746.
  2. Pisano JJ., et al. “Plasmacytoma of the oral cavity and jaws: a clinicopathologic study of 13 cases”. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 83 (1997): 265-271.
  3. Dimopoulos MA., et al. “Solitary plasmacytoma of bone and asymptomatic multiple myeloma”. Blood 96 (2000): 2037-2044.
  4. Singh JP., et al. “Extra-medullary plasmacytoma of maxilla: case report”. Indian Journal of Radiology Imaging 14 (2004): 29-33.
  5. Erdogan BA., et al. “Extramedullary plasmacytoma of maxillary sinus”. Journal of Craniofacial Surgery 24 (2013): 85-687.
  6. Knowling MA., et al. “Comparison of extramedullary plasmacytomas with solitary and multiple plasma cell tumours of bone”. Journal of Clinical Oncology4 (1983): 255-262.
  7. Agostini T., et al. “Solitary plasmacytoma of the jaw”. Journal of Craniofacial Surgery 22 (2011): c2-e1O.
  8. Allegra A Nastro Siniscalchi E., et al. “Extramedullary Plasmacytoma of the Maxilla Simulating a Maxillary Radicular Cyst: Quick Diagnosis and Management”. Journal of Craniofacial Surgery 27 (2016): e296-e297.
  9. Kamal M., et al. “Mandibular Plasmacytoma of Jaw - A Case Report”. Journal of Clinical and Diagnostic Research 8 (2014): ZD20-ZD21.
  10. Chao MW., et al. “Radiotherapy in the management of solitary extramedullary plasmacytoma”. Internal Medicine Journal 35 (2005): 211-215.
  11. Cioranu VI., et al. “Maxillary solitary recurrent plasm-acytoma: a case report”. Chirurgia (Bucur) 108 (2013): 732735.
  12. Rodriguez-Caballero B., et al. “Mandibular solitary plasmacytoma of the jaw: a case report”. Medicina Oral, Patologia Oral, Cirugia Bucal 16 (2011): 647-650.
  13. Hu K and Yahalom J. “Radiotherapy in the management of plasma cell tumors”. Oncology 14 (2000): 101-108.
  14. Tournier-Rangeard L., et al. “Radiotherapy for solitary extramedullary plasmacytoma in the head and neck region: a dose greater than 45 Gy to the target volume improves the local control”. International Journal of Radiation Oncology - Biology - Physics 64 (2006): 1013-1017.
  15. Michalaki VJ., et al. “Definitive radiotherapy for extramedullary plasmacytomas of the head and neck”. The British Journal of Radiology 76 (2003): 738-741.
  16. Altanasio G., et al. “Extramedullary plasmacytoma of paranasal sinuses. A combined therapeutic strategy”. ACTA Otorhinolaryngologica Italica 26 (2006): 118-120.
  17. Katodritou E., et al. “Successful treatment of extramedullary gastric plasmacytoma with the combination of bortezomib and dexamethasone: first reported case”. Leukemia Research 32 (2008): 339-341.
  18. Varettoni M., et al. “Efficacy of Bortezomib followed by local irradiation in two patients with extramedullary plasmacytomas”. Leukemia Research 32 (2008): 839-841.
  19. Katodritou E., et al. “Successful treatment of extramedullary plasmacytoma of the cavernous sinus using a combination of intermediate dose of thalidomide and dexamethasone”. Acta Haematology 117 (2007): 20-23.
  20. Chim CS., et al. “Bortezomib in primary refractory plasmacytoma”. Journal of Clinical Oncology 23 (2005): 2426-2428.
  21. Merza H, Sarkar R. “Solitary extraosseous plasmacytoma”. Clinical Case Reports (2016)4: 851-854.


Citation: Seema Devi., et al. “Extramedullary Plasmacytoma Maxilla - A Case Report" Acta Scientific Cancer Biology 7.3 (2023): 03-07.


Copyright: © 2023 Seema Devi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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