Acta Scientific Cancer Biology (ASCB) (ISSN: 2582-4473)

Mini Review Volume 7 Issue 2

Current Assessment of Phytochemicals in Anticancer Treatment

Ayse Kaplan*

Faculty of Science, Department of Molecular Biology, Eskisehir Technical University, Eskisehir, Turkey

*Corresponding Author: Ayse Kaplan, Molecular Biologist, Faculty of Science, Department of Molecular Biology, Eskisehir Technical University, Eskisehir, Turkey.

Received: March 13, 2023; Published: March 28, 2023

Abstract

Phytochemicals are bioactive compounds for cancer treatment, serving as vital sources for novel drugs. Vinca alkaloids, taxanes, colchicine, podophyllotoxin, camptothecin, irinotecan and roscovitine stand out as the most used potential phytochemicals in cancer treatment. These phytochemicals act by affecting various molecular pathways. The primary aim of this study is to discuss the potential of phytochemicals, which are active compounds in natural products, and to explain their effects on molecular targets. At the same time, the derivatives of these phytochemicals and their effects on various cancer cells are the subject of discussion in this study. The information obtained about anticancer phytochemicals evaluated at preclinical and clinical levels may shed light on new studies to be conducted in the future.

 Keywords: Phytochemicals; Cancer; Irinotecan

References

  1. Choudhari A., et al. “Phytochemicals in cancer treatment: from preclinical studies to clinical practice”. Frontiers in Pharmacology 10 (2020): 1614.
  2. Garcia-Oliveira, et al. “Status and challenges of plant-anticancer compounds in cancer treatment”. Pharmaceuticals 14 (2021): 157.
  3. Singh S., et al. “Lead phytochemicals for anticancer drug development”. Frontiers in Plant Science 7 (2016): 1667.
  4. Zhang D and Kanakkanthara A. “Beyond the paclitaxel and vinca alkaloids: next generation of plant-derived microtubule-targeting agents with potential anticancer activity”. Cancers7 (2020): 1721.
  5. Dhyani P., et al. “Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine”. Cancer Cell International 22 (2022): 206.
  6. Bailly C. “Irinotecan: 25 years of cancer treatment”. Pharmacological Research 148 (2019): 104398.
  7. Zhang G., et al. “Design, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxy-camptothecin derivatives against drug-resistant small-cell lung cancerin vitro and in vivo”. European Journal of Medicinal Chemistry 241 (2022): 114610.
  8. Zhang M., et al. “Anti-tumor effects and mechanism of a novel camptothecin derivative YCJ100”. Life Sciences 311 (2022): 121105.
  9. Pandey V., et al. “Roscovitine effectively enhances antitumor activity of temozolomide in vitroand in vivo mediated by increased autophagy and Caspase-3 dependent apoptosis”. Scientific Reports 9 (2019): 5012.
  10. Mazumder K., et al. “A review on mechanistic insight of plant derived anticancer bioactive phytocompounds and their structure activity relationship”. Molecules9 (2022): 3036.

Citation

Citation: Ayse Kaplan. “Current Assessment of Phytochemicals in Anticancer Treatment" Acta Scientific Cancer Biology 7.2 (2023): 05-07.

Copyright

Copyright: © 2023 Ayse Kaplan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days
Impact Factor1.183

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is May 30, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US