Acta Scientific Cancer Biology (ASCB) (ISSN: 2582-4473)

Review Article Volume 7 Issue 1

Dysregulated Cholesterol Metabolism Including Oxysterols in the Pathophysiology of Breast Cancer: Therapeutic Implications - A Narrative Review

Kulvinder 1, Gautam N2, Gautam NK Allahbadia2 and Mandeep Singh3

1Obstetrics and Gynaecology, Specialist Reproductive Endocrinology and Infertility Specialist, Scientific Director Dr Kulvinder Kochar Kaur, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
2Obstetrics and Gynaecology, D.N.B, Scientific Director, Ex-Rotunda-A Centre for Human Reproduction, Mumbai, India
3Consultant Neurologist, Swami Satyanand Hospital Near Nawi Kachehri, Baradri, Punjab, India

*Corresponding Author: Kulvinder, Obstetrics and Gynaecology, Specialist Reproductive Endocrinology and Infertility Specialist, Scientific Director Dr Kulvinder Kochar Kaur, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India.

Received: November 22, 2022; Published: February 24, 2023


Breast Cancer (BC) represents one of the commonest cancer in case of women. During 2018 it was calculated that mortality of 627, 800 women occurred due to BC. BC has multiple factors contributing to its etiology besides is a chronic disease. Earlier we updated the pathophysiology and treatment of BC. Despite significant advancements have been made regarding its treatment, numerous queries remain regarding carcinogenesis. At the time of carcinogenesis cells illustrate decontrolled cholesterol homeostasis. Subsequent to this intracellular cholesterol accrual takes place which is the requirement for sustenance of greater growth rate. Both cholesterol efflux along with influx represent 2 metabolic pathways which is essential for avoidance of intracellular cholesterol accrual. Liver X receptor (LXRs) reflect nuclear receptors which following activation result in the expression of ABC transporters implicated in facilitating cholesterol efflux besides causing Induction of IDOL (inducible degrader of low density lipoprotein receptor (LDLR) implicated in cholesterol influx reduction. Oxysterols are oxygenated cholesterol products that get generated via various pathways have been invented in the form of LXR particular ligands. Certain Oxysterols are implicated in tumor generation, whereas others are believed to work as anti tumor substances. Thus here we conducted a narrative review utilizing search engine pubmed, google scholar; web of science; embase; Cochrane review library utilizing the MeSH terms like Breast Cancer; cholesterol homeostasis; LXRs; Oxysterols; 27OHC; pro-protein convertase subtilisn/kexin type9 (PCSK9) in BC generation, from 1983 till date 2022. We found over 2000 articles where we used 50 articles due to journal specification for this review. Here we detail regarding the implication of cholesterol, Oxysterols along with LXRs in the pathophysiology of BC, highlighting the biological actions of LXRs ligands. Further the part of PCSK9 regarding the breast cancer robustness along with cholesterogenic gene signatures might aid in anticipating prognosis of young breast cancer patients.

Keywords: BC; Cholesterol; LXRs; Oxysterols


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Citation: Kulvinder.,et al. “Dysregulated Cholesterol Metabolism Including Oxysterols in the Pathophysiology of Breast Cancer: Therapeutic Implications - A Narrative Review" Acta Scientific Cancer Biology 7.1 (2023): 07-14.


Copyright: © 2022 Kulvinder.,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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