Acta Scientific Cancer Biology (ASCB) (ISSN: 2582-4473)

Research Article Volume 6 Issue 5

Patterns of Invasive Tumour Border in Cutaneous Melanoma are Associated with Prognostic Indicators

Elizabeth Keeling2, Dermot B McKenna2 and Paul H Hartel1,3,4*

1Department of Pathology, Sligo University Hospital, Sligo, Ireland
2Department of Dermatology, Sligo University Hospital, Sligo, Ireland
3National University of Ireland, Galway School of Medicine, Galway, Ireland
4West Virginia University School of Medicine, Morgantown, WV, USA

*Corresponding Author: Paul H Hartel, Department of Pathology, Sligo University Hospital, Sligo, Ireland.

Received: July 12, 2022; Published: July 29, 2022

Abstract

The pattern of histological invasion observed in certain malignancies such as colorectal carcinoma and breast carcinoma has been shown to be associated with prognosis. To date the prognostic significance of the histological pattern of invasion has not been described in malignant melanoma. We evaluated the histologic invasive border pattern in a series of 76 malignant melanomas to determine its relationship with other clinical and prognostic pathologic variables. Lymphovascular invasion, perineural invasion and precursor naevus were observed more commonly in melanomas with an infiltrative compared to a pushing border (9.0% vs 4.6%; 15.0% vs 9.3%; and 21.0% vs 14.0%, respectively). Ulceration was seen almost twice as commonly in the pushing compared to the infiltrative variant (30.2% vs. 15.0%), and regression was also more commonly observed in melanomas with a pushing versus an infiltrative border (16.3% vs 9.0%). No difference was seen with gender, age, tumour location, size, subtype, pigmentation, Breslow thickness, lymphocytic infiltrate or mitoses. We suggest that tumour border pattern be included in pathology synoptic reporting of malignant melanomas to facilitate further research and potential clinical application.

Keywords:Malignant Melanoma; Melanoma Tumour Border; Lymphovascular Invasion; Perineural Invasion; Ulceration; Regression

References

  1. Bolognia J., et al. “Dermatology”. Fourth edition. China: Elsevier (2018).
  2. Lino- Silva LS., et al. “Tumour budding in rectal cancer. A comprehensive review”. Contemporary Oncology (Pozn) 2 (2018): 61-74.
  3. Koelzer VH., et al. “The tumor border configuration of colorectal cancer as a histomorphological prognostic indicator”. Frontiers in Oncology 18.4 (2014): 29.
  4. Kassim S., et al. ”Androgen receptor gene methylation and exon one CAG repeat length in ovarian cancer: differences from breast cancer”. IUBMB Life7 (2004): 417-426.
  5. Perkins A., et al. “Atypical moles: diagnosis and management”. American Family Physician 11 (2015): 762-767.
  6. Lee TK., et al. “Predictive power of irregular border shapes for malignant melanomas”. Skin Research and Technology 1 (2005): 1-8.
  7. Brown M. “Staging and prognosis of melanoma”. Seminars in Cutaneous Medicine and Surgery 2 (1997): 113-21.
  8. Elder DE., et al. “Neoplastic progression and prognosis in melanoma”. Seminars in Cutaneous Medicine and Surgery 15.4 (1996): 336-348.
  9. Elder D. “Tumor progression, early diagnosis and prognosis of melanoma”. Acta Oncologica 5 (1999): 535-547.
  10. Appleton SE., et al. “Vertical Growth Phase as a Prognostic Factor for Sentinel Lymph Node Positivity in Thin Melanomas: A Systematic Review and Meta-Analysis”. Plastic and Reconstructive Surgery 141.6 (2018): 1529-1540.
  11. McCarthy SW., et al. “Cutaneous malignant melanoma in teenagers”. Histopathology5 (1994): 453-461.
  12. Quatresooz P., et al. “Angiogenic fast-growing melanomas and their micrometastases”. European Journal of Dermatology 3 (2010): 302-307.
  13. Quatresooz P., et al. ”Malignant melanoma microecosystem: Immunohistopathological insights into the stromal cell phenotype”. Experimental and Therapeutic Medicine 3 (2011): 379-384.
  14. Piérard GE., et al. “Malignant melanoma and its stromal nonimmune microecosystem”. Journal of Oncology (2012): 584219.
  15. Callender GG., et al. “What does ulceration of a melanoma mean for prognosis?” Advances in Surgery 45 (2011): 225-236.
  16. Abbas O., et al. “Cutaneous malignant melanoma: update on diagnostic and prognostic biomarkers”. The American Journal of Dermatopathology 5 (2014): 363-379.
  17. Cartron AM., et al. “Reporting regression in primary cutaneous melanoma. Part 2: prognosis, evaluation and management”. Clinical and Experimental Dermatology 7 (2020): 818-823.
  18. Guo S., et al. “Effect of Stromal Cells in Tumor Microenvironment on Metastasis Initiation”. International Journal of Biological Sciences 14.14 (2018): 2083-2093.
  19. Pampena R., et al. “Nevus-associated melanoma: facts and controversies”. Italian Journal of Dermatology and Venereology 1 (2020): 65-75.
  20. Tas F., et al. “Histological lymphovascular invasion is associated with nodal involvement, recurrence, and survival in patients with cutaneous malignant melanoma”. International Journal of Dermatology 2 (2017): 166-170.
  21. Maroldi R., et al. “Perineural tumor spread”. Neuroimaging Clinics of North America 2 (2008): 413-429.

Citation

Citation: Paul H Hartel., et al. “Patterns of Invasive Tumour Border in Cutaneous Melanoma are Associated with Prognostic Indicators”. Acta Scientific Cancer Biology 6.5 (2022): 21-29.

Copyright

Copyright: © 2022 Paul H Hartel., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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Impact Factor1.183

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