Acta Scientific Cancer Biology (ASCB) (ISSN: 2582-4473)

Research Article Volume 6 Issue 5

Patterns of Invasive Tumour Border in Cutaneous Melanoma are Associated with Prognostic Indicators

Elizabeth Keeling2, Dermot B McKenna2 and Paul H Hartel1,3,4*

1Department of Pathology, Sligo University Hospital, Sligo, Ireland
2Department of Dermatology, Sligo University Hospital, Sligo, Ireland
3National University of Ireland, Galway School of Medicine, Galway, Ireland
4West Virginia University School of Medicine, Morgantown, WV, USA

*Corresponding Author: Paul H Hartel, Department of Pathology, Sligo University Hospital, Sligo, Ireland.

Received: July 12, 2022; Published: July 29, 2022


The pattern of histological invasion observed in certain malignancies such as colorectal carcinoma and breast carcinoma has been shown to be associated with prognosis. To date the prognostic significance of the histological pattern of invasion has not been described in malignant melanoma. We evaluated the histologic invasive border pattern in a series of 76 malignant melanomas to determine its relationship with other clinical and prognostic pathologic variables. Lymphovascular invasion, perineural invasion and precursor naevus were observed more commonly in melanomas with an infiltrative compared to a pushing border (9.0% vs 4.6%; 15.0% vs 9.3%; and 21.0% vs 14.0%, respectively). Ulceration was seen almost twice as commonly in the pushing compared to the infiltrative variant (30.2% vs. 15.0%), and regression was also more commonly observed in melanomas with a pushing versus an infiltrative border (16.3% vs 9.0%). No difference was seen with gender, age, tumour location, size, subtype, pigmentation, Breslow thickness, lymphocytic infiltrate or mitoses. We suggest that tumour border pattern be included in pathology synoptic reporting of malignant melanomas to facilitate further research and potential clinical application.

Keywords:Malignant Melanoma; Melanoma Tumour Border; Lymphovascular Invasion; Perineural Invasion; Ulceration; Regression


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Citation: Paul H Hartel., et al. “Patterns of Invasive Tumour Border in Cutaneous Melanoma are Associated with Prognostic Indicators”. Acta Scientific Cancer Biology 6.5 (2022): 21-29.


Copyright: © 2022 Paul H Hartel., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate35%
Acceptance to publication20-30 days
Impact Factor1.183

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