Brenna Daily¹ and Paul Hartel²*

¹Atlantic Technological University, Sligo, Ireland
²Department of Pathology, Sligo University Hospital, Sligo, Ireland

*Corresponding Author: Paul Hartel, Department of Pathology, Sligo University Hospital, Sligo, Ireland.

Received: May 30, 2022; Published: July 14, 2022

Abstract

While genetic mutations can offer targeted therapy for some cancer patients, many patients have tumours that lack currently utilised genetic treatment targets. With the advent of immune-modulator cancer therapy, we evaluated the relationship between genetic mutation status and tumour-associated inflammatory response in 56 needle biopsies of tumour metastases. From histopathology clinical audit data, we documented the range of metastatic tumour types in adult female and male patients and noted their histologic and molecular characteristics. Surrounding inflammatory response to these tumours was graded according to severity. Presence of genetic mutations used in targeted treatment was associated with weak inflammation while absence of these mutations was associated with brisk inflammation. As targeted therapy is not available for patients with tumours lacking specific genetic mutations, it is worth exploring whether they may benefit from immune-based treatments.

Keywords: Cancer Immunotherapy; Tumour-inflammatory Response; Genetic Mutation; Targeted Therapy; Immune Modulation

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Citation

Citation: Brenna Daily and Paul Hartel. “Genetic Mutational Status and Tumour-inflammatory Response in Metastatic Cancer: New Implications for Exploring Immunotherapies" Acta Scientific Cancer Biology 6.5 (2022): 09-12.

Copyright

Copyright: © 2022 Brenna Daily and Paul Hartel. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.