Genetic Mutational Status and Tumour-inflammatory Response in Metastatic Cancer: New Implications for Exploring Immunotherapies
Brenna Daily1 and Paul Hartel2*
1Atlantic Technological University, Sligo, Ireland
2Department of Pathology, Sligo University Hospital, Sligo, Ireland
*Corresponding Author: Paul Hartel, Department of Pathology, Sligo University Hospital, Sligo, Ireland.
May 30, 2022; Published: July 14, 2022
While genetic mutations can offer targeted therapy for some cancer patients, many patients have tumours that lack currently utilised genetic treatment targets. With the advent of immune-modulator cancer therapy, we evaluated the relationship between genetic mutation status and tumour-associated inflammatory response in 56 needle biopsies of tumour metastases. From histopathology clinical audit data, we documented the range of metastatic tumour types in adult female and male patients and noted their histologic and molecular characteristics. Surrounding inflammatory response to these tumours was graded according to severity. Presence of genetic mutations used in targeted treatment was associated with weak inflammation while absence of these mutations was associated with brisk inflammation. As targeted therapy is not available for patients with tumours lacking specific genetic mutations, it is worth exploring whether they may benefit from immune-based treatments.
Keywords: Cancer Immunotherapy; Tumour-inflammatory Response; Genetic Mutation; Targeted Therapy; Immune Modulation
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