Tissues Protein Microenvironment and Survival by Age at Cancers
Trasplantology and Stem Cells Department (TSC dept), A.M Granov’s Russian Research Center for Radiology and Surgical Technologies, (A.M Granov’s RRCRST), Russia
*Corresponding Author: AN Shoutko, Trasplantology and Stem Cells Department (TSC dept), A.M Granov’s Russian Research Center for Radiology and Surgical Technologies, (A.M Granov’s RRCRST), Russia.
June 07, 2022; Published: June 21, 2022
Introduction: Three general types of survival by age characterize the effectiveness of conventional cancer treatment in a population of developed country. To explain big difference between received results, the microenvironment of normal tissues investigated and compared with clinical data.
Material and Method: Open database for cancer survival by age in UK and open database for human proteins in normal human tissues used for extraction of original information for 16 cancers () and 18 proteins in normal tissues, which are host/primary for corresponding malignancy. All original data for protein levels transformed by normalization to both level in bone marrow. The transformed data were analyzed and compared with three general types survival by age, using statistical instruments of Excel.
Results: Three cohorts of sixteen cancers of UK population’s data differ around 7 times according to exponential rate of survival’s decline by age. The average result of therapy in cohorts is better, the higher the average level of markers for hematopoietic (CD34) and vasculogenic (CD31) cells in normal tissues corresponded to cancer’s cohorts. The level of immune markers for T-, B-cells, and neutrophils in normal tissues are lower, than stem cells, young lymphoid descendants, and endothelial ones. The result of therapy in cohorts is the better, the lover level of immune markers in normal tissues, corresponded to cohorts i.e.the more shift to the "stemness" in the differentiation's range. The number of markers for hematopoietic stem cells and their descendants in normal tissues varies in the opposite way.
Discussion: Despite common domination of hematopoietic stem cells markers in normal tissues, their number may vary by physiology of inter-organs flows of the fluids. The higher morphogenic resource of CD34 and CD31 in normal tissue can extend the local tumor growth, delay a coming hypoxia, metastases, and death.
Conclusion: The proteins microenvironment of normal human tissues, as a host of unpredictable malignancy, does not correspond completely to the usual markers in terms of circulating blood cells. The domination of “CD34- stemness” and “CD31-vasculogenity” provide a local longevity of tumor and thus delay the shift of its logarithmic growth into quasi-linear, the offensive of hypoxia, followed metastases and death.
Keywords: Survival; Age Population; Cancers; Normal Host-Tissues; Protein Tissue Markers; Hematopoietic Stem Cells; Circulating Cells
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