Acta Scientific Cancer Biology (ASCB) (ISSN: 2582-4473)

Research Article Volume 6 Issue 7

Epidermal Growth Factor Receptor (EGFR) Mutation Status in Egyptian Patients with Non-Small Cell Lung Cancer (NSCLC); Can it be Predicted?

Rabab Gaafar1, Abeer Bahnassy2, Ahmed Bastawissy1, Hala Aziz1, Anan O Abdel-Aleem3, Emad R Issak4* and Nagla Karim5

1Medical Oncology department, National Cancer Institute, Cairo University, Cairo, Egypt
2Tissue culture and Cytogenetics Unit, Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
3Cancer Biology Department, NCI, Cairo University, Cairo, Egypt
4Immunology Department, Ain Shams University, Cairo, Egypt
5Medical Oncology Department, Georgia institute, USA

*Corresponding Author: Emad R Issak, Immunology Department, Ain Shams University, Cairo, Egypt.

Received: May 01, 2022; Published: June 03, 2022

Abstract

Objectives: The study was to assess frequency and patterns of Epidermal Growth Factor Receptor (EGFR) mutation status in a cohort of Egyptian patients with Non-Small Cell Lung Cancer (NSCLC) from the National Cancer Institute (NCI), Cairo University. Also, it aimed to investigate the association of the EGFR mutation status to several clinico-pathological features of patients.

Methods: EGFR mutation status was assessed in tumor tissue samples of 141 NSCLC patients from Egypt presenting to the NCI, Cairo University from December 2014 to January 2018. The association of EGFR mutation status to the relevant clinical and pathological features of the patients was studied using the logistic regression.

Results: EGFR mutations were detected in 33 (23.4%) patients. The most detected were 19 Del (18 patients; 12.77%), exon 21 (13 patients; 9.22%), exon 21+T790M, and G719X (one patient; 0.71%); each. EGFR mutation status was associated significantly to advanced disease stage (p < 0.001), brain metastasis 8/19 (42.11%, p = 0.049) and contralateral lung metastasis 7/14 (50%, p = 0.038). EGFR mutations were also higher in females (non-smokers (35%) and in males smokers (20.9%, p < 0.001). Multivariate analysis showed that only the contralateral lung metastasis is an independent predictor for EGFR mutations in the NSCLC patients.

Conclusion: EGFR mutations are relatively common (23.4%) in NSCLC patients from Egypt (NCI experience). Therefore, testing for EGFR mutations in NSCLC should be done routinely for those patients for better treatment outcomes.

Keywords: NSCLC; EGFR Mutations; Exons 19, 21, T790M and Metastasis

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Citation

Citation: Rabab Gaafar., et al. “Epidermal Growth Factor Receptor (EGFR) Mutation Status in Egyptian Patients with Non-Small Cell Lung Cancer (NSCLC); Can it be Predicted?: Acta Scientific Cancer Biology 6.7 (2022): .

Copyright

Copyright: © 2022 Emad R Issak., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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Impact Factor1.183

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