Acta Scientific Cancer Biology (ASCB) (ISSN: 2582-4473)

Case Report Volume 6 Issue 3

Primary Myxoid Liposarcoma of Breast with Round Cell Component - Report of A Rare Case with Review of Literature

Kusuma Venkatesh1*, Chethana Mannem2 and Sneha A Motwani3

1Former Professor and HOD, Department of Pathology, Kempegowda Institute of Medical Sciences, Bangalore, India
2Associate Professor, Department of Pathology, Kempegowda Institute of Medical Sciences, Bangalore, India
3Post Graduate and Tutor, Department of Pathology, Kempegowda Institute of Medical Sciences, Bangalore, India

*Corresponding Author: Kusuma Venkatesh, Professor of Pathology, Presently working at East Point College of Medical Sciences and Research centre, Bangalore, India.

Received: February 24, 2022; Published: March 10, 2022


Primary breast sarcomas are rare tumors constituting <1% of breast malignancies of which liposarcoma accounts for only 0.3%. A 58year-old female presented with a lump in the left breast of 2 years duration, gradually increasing in size and was associated with pain. On examination, she had a firm to hard large lump in the left breast involving all the quadrants. Fine Needle Aspiration Cytology was reported as phyllodes tumor. The patient underwent simple mastectomy. Grossly, the specimen was large, measuring 20.0×18.0×10.0 cm having a markedly variegated cut surface with solid and cystic areas. Solid areas appeared predominantly gelatinous. Histopathological examination of solid areas showed malignant spindle cell neoplasm with lipoblasts in myxoid stroma and numerous arborizing blood vessels. Focal areas had round cells with moderate amount of vacuolated cytoplasm. There were portions of necrosis and cystic degenerations. A diagnosis of primary myxoid liposarcoma was made and has been reported as it is a rare tumor in the breast with characteristic histopathology.

Keywords: Primary Breast Sarcoma; Myxoid Liposarcoma of Breast


  1. Adem C., et al. “Primary breast sarcoma: Clinicopathologic series from the Mayo Clinic and review of the literature”. British Journal of Cancer 91 (2004): 237-241.
  2. Parikh BC., et al. “Liposarcoma of the breast-a case report”. European Journal of Gynaecological Oncology 28 (2007): 425-427.
  3. Rosen PP. “Sarcoma. Breast Pathology”. Philadelphia, Pa: Lippincott-Raven (1997): 713-714.
  4. Briski LM and Jorns JM. “Primary Breast Atypical Lipomatous Tumor/ Well- Differentiated Liposarcoma and Dedifferentiated Liposarcoma”. Archives of Pathology and Laboratory Medicine 142 (2018): 268-274.
  5. Austin RM and Dupree W. “Liposarcoma of the breast: A clinico-pathologic study of 20 cases”. Human Pathology 17 (1986): 906-913.
  6. Tavassoli FA. “Mesenchymal lesions. Pathology of the Breast”. East Norwalk, Conn: Appleton and Lang (1999): 706-709.
  7. Powell CM and Rosen PP. “Adipose differentiation in cystosarcoma phyllodes”. The American Journal of Surgical Pathology 18 (1994): 720-727.
  8. Demaria S., et al. “Fine needle aspiration of primary pleomorphic liposarcoma of the breast: A case report”. Acta Cytology 43 (1999): 1131-1136.
  9. Schneider-Stock R., et al. “MDM2 amplification and loss of heterozygosity at Rb and p53 genes: No simultaneous alterations in the oncogenesis of liposarcomas”. Journal of Cancer Research and Clinical Oncology 124 (1998): 532-540.


Citation: Kusuma Venkatesh., et al. “Primary Myxoid Liposarcoma of Breast with Round Cell Component - Report of A Rare Case with Review of Literature" 6.3 (2022): 03-06.


Copyright: © 2022 Kusuma Venkatesh., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate35%
Acceptance to publication20-30 days
Impact Factor1.183

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is April 30th, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue".
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US