Acta Scientific Cancer Biology (ASCB) (ISSN: 2582-4473)

Mini Review Volume 6 Issue 2

A Review on Role of Red Wine Polyphenols in Cancer Treatment

Shiuli Guchait*

Department of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, India

*Corresponding Author: Shiuli Guchait, Department of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, India.

Received: January 27, 2022; Published: February 07, 2022

Abstract

This paper presents an overview of the role of red wine polyphenols in cancer treatments. Nowadays one of the deadliest diseases in the world is cancer. According to the World Health Organization, cancer is known to be the second leading cause of death across the world. The most common cancer treatment plans are either surgery, radiation therapy or chemotherapy. But these conventional cancer therapies result in serious adverse effects in humans. A recent study shows that an antioxidant found in grape skins and seeds, known as resveratrol, a part of a group of phenolic compounds called polyphenol. Grape polyphenols are used for preventing diseases caused due to oxidative stress. It prevents cancer cells from replicating and spreading inside and enhances the effectiveness of radiation and chemotherapy cancer treatments. Various phytochemicals found in wine such as lignans, quercetin, and resveratrol have estrogenic properties. Animal research suggests that they synergistically change the gene expression in cancer cells to inhibit their growth and colony formation and thus reduce the incidence of cancer.

Keywords: Red Wine; Cancers; Polyphenols; Resveratrol; Phenolic Compounds; Antioxidants; Phytochemicals

References

  1. Surh YJ. “Cancer chemoprevention with dietary phytochemicals”. Nature Reviews Cancer 3 (2003): 768-
  2. Joseph F Gonzales., et al. “Applying the precautionary principle to nutrition and cancer”. The Journal of the American College of Nutrition 3 (2014): 239-246.
  3. Yue Zhou., et al. “Natural Polyphenols for Prevention and Treatment of Cancer”. Nutrients 8 (2006): 515.
  4. Pedersen A., et al. “Relations between amount and type of alcohol and colon and rectal cancer in a Danish population-based cohort study”. Gut 52 (2003): 861-867.
  5. Del Pino-García R., et al. “The effects of heat treatment on the phenolic composition and antioxidant capacity of red wine pomace seasonings”. Food Chemistry 221 (2017): 1723-1732.
  6. Waterhouse AL. “Wine phenolics”. Annals of the New York Academy of Sciences 957 (2002): 21-36.
  7. Kundu JK and Surh YJ. “Molecular basis of chemoprevention by resveratrol: NF-κB and AP-1 as potential targets”. Mutation Research 555 (2004): 65-80.
  8. Jang M., et al. “Cancer chemopreventive activity of resveratrol, a natural product derived from grapes”. Science 275 (1997): 218-220.
  9. S Sharma., et al. Cancer Research 54 (1994): 5848
  10. Jae-Hoon Jeong., et al. “Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression”. Journal of Cellular Biochemistry 1 (2009): 73-82.
  11. Abdur Rauf., et al. “Anticancer potential of quercetin: A comprehensive review”. Phytotherapy Research 11 (2018): 2109-2130.
  12. EIAttar TM and Virji AS. “Modulating effect of resveratrol and quercetin on oral cancer cell growth and proliferation”. Anti-Cancer drugs 10 (1999): 187-193.
  13. Xu Z. “Important antioxidant phytochemicals in agricultural food products”. In Analysis of Antioxidant-Rich Phytochemicals; Xu, Z., Howard, L.R., Eds.; Wiley-Blackwell Publisher: Oxford, UK (2012): 1-24.
  14. Panche AN., et al. “Flavonoids: An overview”. Journal of Nutritional Science 5 (2016): e47.
  15. Arts IC., et al. “Catechin contents of foods commonly consumed in The 1. Fruits, vegetables, staple foods, and processed foods”. Journal of Agricultural and Food Chemistry 48 (2000): 1746-1751.
  16. Haiyan Sun., et al. “Anti-Cancer Activity of Catechin against A549 Lung Carcinoma Cells by Induction of Cyclin Kinase Inhibitor p21 and Suppression of Cyclin E1 and P-AKT”. Applied Sciences 6 (2020): 2065.
  17. Kotha , et al. “Dietary Polyphenols Suppress Elevated Levels of Proinflammatory Mediators and Aromatase in the Mammary Gland of Obese Mice” Cancer Prevention Research 6.9 (2013): 886-897.
  18. Esteban J., et al. “Detection of intratumoral aromatase in breast carcinomas: an immunohistochemical study with clinicopathologic correlation”. The American Journal of Pathology 140 (1992): 337-343.
  19. Bulun SE., et al. “A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription”. The Journal of Clinical Endocrinology and Metabolism 77 (1993): 1622-1628.
  20. Santen RJ., et al. “Stromal spindle cells contain aromatase in human breast tumors”. The Journal of Clinical Endocrinology and Metabolism 79 (1994): 627-632.
  21. Lu Q., et al. “Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers”. Endocrinology 137 (1996): 3061-3068.
  22. Rosário Monteiro., et al. “Modulation of Aromatase Activity by Diet Polyphenolic Compounds”. Journal of Agricultural and Food Chemistry 10 (2006): 3535-3540.

Citation

Citation: Shiuli Guchait. “A Review on Role of Red Wine Polyphenols in Cancer Treatment". 6.2 (2022): 09-12.

Copyright

Copyright: © 2022 Shiuli Guchait. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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Acceptance rate35%
Acceptance to publication20-30 days
Impact Factor1.183

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