Showket Yahya* and G Sudhandiran

Cell Biology Laboratory, Department of Biochemistry, University of Madras, Guindy Campus, Chennai

*Corresponding Author: Showket Yahya, Cell Biology Laboratory, Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.

Received: December 31, 2021; Published: January 01, 2022

DOI 10.31080/ASCB.2023.06.0361

Abstract

Colon cancer also called colorectal cancer has become one of the deadliest cancers with incidence rates of 4.3% and 4.10% in men and women respectively. It has been reported that CRC is mainly due to cellular/ER stresses such as hypoxia, which may lead to the accumulation of reactive oxygen species (ROS). So, it is essential to scavenge these ROS. Sestrin2 (Sesn2) is known to suppress ROS accumulation by regulating various signalling pathways such as Nrf2/Keap1 pathways and maintaining mitochondrial homeostasis through the AMPK/mTOR pathway etc., thereby inducing autophagy. This review provides an overview of the Nrf2-Keap1 signalling pathway, the dual role of Nrf2, and autophagy in cancer, along with the role of sestrin2 in triggering autophagy in colon cancer cells.

Keywords: Colon Cancer; Cellular/Er Stress; ROS; Homeostasis; Sestrin2; Nrf2/Keap1 Signalling Pathway; Autophagy

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Citation

Citation: Showket Yahya and G Sudhandiran. “Critical Role of Sestrin2 in Regulating Nrf2/Keap1 Pathway and Mediating Autophagy in Colon Cancer 6.1 (2022): 10-16.

Copyright

Copyright: © 2022 Showket Yahya and G Sudhandiran. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.