Somatic Mutations and Cancer
Muhammad Saleem1, Munir Ahmed2, Aamir Ali Abro3 and Gang Chen1*
1College of Bioscience and Biotechnology, Yangzhou University, Jiangsu, China
2College of Food Science and Engineering, Yangzhou University, Jiangsu, China
3State Key Laboratory of Cotton, Biology Institute of Cotton Research Institute, Chinese Academy of Agriculture Sciences Anyang (CAAS), PR China
*Corresponding Author: Gang Chen, College of Bioscience and Biotechnology, Yangzhou University, Jiangsu, China.
July 12, 2021; Published: August 19, 2021
Most of the mutations that accumulate in somatic cells throughout the life time of a person do not have any effects but some mutations can cause serious consequences like cancer (which after originating from a a single cell due to mutations in the genome starts to behave abnormally). There was a limited information of mutational processes and its consequences but recent advances in genome sequencing technologies due to unprecedented efforts has greatly revolutionized our understandings in this regard. In this review, I have briefly summarized about our current knowledge of the somatic mutations that that lead to cancer, its causes, possible ways which we are using for further studies and future premises.
Keywords: Somatic Mutations; Cancer; Aging; Genome; Repair Mechanism; Driver Mutations; Passenger Mutations; DNA Sequencing Technology
- Lichtenstein AV. “Genetic mosaicism and cancer: cause and effect”. Cancer Research6 (2018): 1375-1378.
- Goldblatt EM and WH Lee. “From bench to bedside: the growing use of translational research in cancer medicine”. American Journal of Translational Research1 (2010): 1.
- Watson JD. “Molecular biology of the gene”. Pearson Education India (2004).
- Vijg J. “Somatic mutations, genome mosaicism, cancer and aging”. Current Opinion in Genetics and Development 26 (2014): 141-149.
- Greenman C., et al. “Patterns of somatic mutation in human cancer genomes”. Nature 7132 (2007): 153-158.
- Simpson AG. “The natural somatic mutation frequency and human carcinogenesis”. Advances in Cancer Research 71 (1997): 209-240.
- Sturtevant A. “Essays on evolution. I. On the effects of selection on mutation rate”. The Quarterly Review of Biology 4 (1937): 464-467.
- Negrini S., et al. “Genomic instability—an evolving hallmark of cancer”. Nature Reviews Molecular Cell Biology3 (2010): 220-228.
- López-Otín C., et al. “The hallmarks of aging”. Cell6 (2013): 1194-1217.
- Tate JG., et al. “COSMIC: the catalogue of somatic mutations in cancer”. Nucleic Acids Research 47 (2019): D941-D947.
- Martincorena I., et al. “Somatic mutant clones colonize the human esophagus with age”. Science 6417 (2018): 911-917.
- Wunderlich V. “Early references to the mutational origin of cancer”. International Journal of Epidemiology1 (2007): 246-247.
- Whitman R. “Somatic Mutations as a Factor in the Production of Cancer: A Critical Review of v. Hansemann's Theory of Anaplasia in the Light of Modern Knowledge of Genetics”. The Journal of Cancer Research 2 (1919): 181-202.
- Hansemann D. “Ueber asymmetrische Zelltheilung in Epithelkrebsen und deren biologische Bedeutung”. Archiv für pathologische Anatomie und Physiologie und für klinische Medicin2 (1890): 299-326.
- Nowell PC. “The clonal evolution of tumor cell populations”. Science4260 (1976): 23-28.
- Hoenicke L and L Zender. “Immune surveillance of senescent cells—biological significance in cancer-and non-cancer pathologies”. Carcinogenesis6 (2012): 1123-1126.
- Alexandrov LB., et al. “Mutational signatures associated with tobacco smoking in human cancer”. Science 6312 (2016): 618-622.
- Michael RS., et al. “The cancer genome”. Nature 7239 (2009): 719-724.
- Imielinski M., et al. “Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing”. Cell6 (2012): 1107-1120.
- Yancik R and LA Ries. “Cancer in older persons: an international issue in an aging world”. in Seminars in oncology. Elsevier (2004).
- Loftfield E., et al. “Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank”. Scientific Reports1 (2018): 1-10.
- Welch JS., et al. “The origin and evolution of mutations in acute myeloid leukemia”. Cell2 (2012): 264-278.
- Bina-Stein M., et al. “Rapid sequence determination of late simian virus 40 16S mRNA leader by using inhibitors of reverse transcriptase”. Proceedings of the National Academy of Sciences2 (1979): 731-735.
- Taniguchi H. “Badanie wpływu wybranych mutacji genu BRAF na rozwój nowotworu wątroby–badania modelowe z wykorzystaniem linii komórkowych ssaków”.
- Greenblatt M. “Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis”. Cancer Research 54 (1994): 4855-4878.
- Cariello NF., et al. “Database and software for the analysis of mutations in the human p53 gene”. Cancer Research16 (1994): 4454-4460.
- Alexandrov LB and MR Stratton. “Mutational signatures: the patterns of somatic mutations hidden in cancer genomes”. Current Opinion in Genetics and Development 24 (2014): 52-60.
- Machiela MJ and SJ Chanock. “Detectable clonal mosaicism in the human genome”. in Seminars in hematology. Elsevier (2013).