Diagnostic Implication of Bone Marrow Mesenchymal Stem Cells (BMSC) Exosomal MicroRNA-632 on Chronic Atrophic Gastritis
Zaibiao Wang1, Manman Yin2, Jiayun Shao3, Jie Peng1, Longhai Li2 and Liye MA4*
1Department of General Surgery, The People's Hospital of Bozhou, Bozhou, China
2Department of Science and Education, The People's Hospital of Bozhou, Bozhou, China
3Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China
4Department of General Surgery, Changhai Hospital, Naval Military Medical University, Shanghai, China
*Corresponding Author: Liye MA, Department of General Surgery, Changhai Hospital, Naval Military Medical University, Shanghai, China.
July 29, 2021; Published: August 13, 2021
Evidence has indicated the significance of microRNAs (miRNAs) derived from Bone marrow mesenchymal stem cells (BMSC)exosomes (BMSC-exo). We aimed to investigate the potential of miR-632 as a therapeutic target for diagnosis and treatment for chronic atrophic gastritis. We collected 96 serum samples from patients with chronic atrophic gastritis and the expression level of miR-632 was investigated in these samples by RT-qPCR. The relationship between the miRNA level and prognosis and patients’ characteristics was evaluated. The expression of miR-632 was significantly not associated with the sex, age, pathogenic site, and the size of serum BMSC-exo (p > 0.05), but miR-632 expression was related to the development of chronic atrophic gastritis and neoplastic progression: gastric cancer of intestinal type group> chronic atrophic gastritis complicated with intraepithelial neoplasia group> chronic atrophic gastritis complicated with intestinal metaplasia group> chronic non-atrophic gastritis group (p < 0.05). Downregulated expression of miR-632 predicted greater survival (124.23 ± 12.43 months) compared to the higher miR-632 expression with survival time of 68.34 ± 10.90 months (p < 0.05). Expression level of miR-632 relates to the inflammation-mediated carcinogenesis and prognosis of chronic atrophic gastritis, which still further requires systematic investigation.
Keywords: BMSC; Chronic Atrophic Gastritis; MicroRNA-632; Inflammation-mediated Carcinogenesis; Exosome
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