Zaibiao Wang¹, Manman Yin², Jiayun Shao³, Jie Peng¹, Longhai Li² and Liye MA⁴*

¹Department of General Surgery, The People's Hospital of Bozhou, Bozhou, China
²Department of Science and Education, The People's Hospital of Bozhou, Bozhou, China
³Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China
⁴Department of General Surgery, Changhai Hospital, Naval Military Medical University, Shanghai, China

*Corresponding Author: Liye MA, Department of General Surgery, Changhai Hospital, Naval Military Medical University, Shanghai, China.

Received: July 29, 2021; Published: August 13, 2021

Abstract

Evidence has indicated the significance of microRNAs (miRNAs) derived from Bone marrow mesenchymal stem cells (BMSC)exosomes (BMSC-exo). We aimed to investigate the potential of miR-632 as a therapeutic target for diagnosis and treatment for chronic atrophic gastritis. We collected 96 serum samples from patients with chronic atrophic gastritis and the expression level of miR-632 was investigated in these samples by RT-qPCR. The relationship between the miRNA level and prognosis and patients’ characteristics was evaluated. The expression of miR-632 was significantly not associated with the sex, age, pathogenic site, and the size of serum BMSC-exo (p > 0.05), but miR-632 expression was related to the development of chronic atrophic gastritis and neoplastic progression: gastric cancer of intestinal type group> chronic atrophic gastritis complicated with intraepithelial neoplasia group> chronic atrophic gastritis complicated with intestinal metaplasia group> chronic non-atrophic gastritis group (p < 0.05). Downregulated expression of miR-632 predicted greater survival (124.23 ± 12.43 months) compared to the higher miR-632 expression with survival time of 68.34 ± 10.90 months (p < 0.05). Expression level of miR-632 relates to the inflammation-mediated carcinogenesis and prognosis of chronic atrophic gastritis, which still further requires systematic investigation.

Keywords: BMSC; Chronic Atrophic Gastritis; MicroRNA-632; Inflammation-mediated Carcinogenesis; Exosome

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Citation

Citation: Liye MA., et al. “Diagnostic Implication of Bone Marrow Mesenchymal Stem Cells (BMSC) Exosomal MicroRNA-632 on Chronic Atrophic Gastritis”. Acta Scientific Cancer Biology 5.9 (2021): 05-09.

Copyright

Copyright: © 2021 Liye MA., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.