Antiviral Impact of Melatonin with Reference to Influenza Virus and Covid-19 Infection
Seema Rai* and Suman Rathore
Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India
*Corresponding Author: Seema Rai, Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India.
June 20, 2021; Published: July 13, 2021
Melatonin has long been considered to play a crucial role in our interactions with viruses. Influenza, sometimes known as the flu, is an RNA virus-borne infectious illness to play a crucial role in our interactions with viruses. Influenza, sometimes known as the flu, is an RNA virus-borne infectious illness TNF-α, IL-6, and IFN-γ are inflammatory cytokines. IFN-γ inhibits the viral infection. Melatonin therapy dramatically reduces TNF-α, IL-6, and IFN-γ expression while increasing IL-10 and TGF-β production, according to this study. Melatonin promotes the synthesis of IL-10 by upregulating the expression of IL-27 in dendritic cells. Melatonin also decreases the levels of TNF-α in CD8 T cells in a considerable way. Compared to ribavirin alone, melatonin plus ribavirin co-treatment dramatically enhances the lifespan of virus-infected mice. Melatonin therapy decreases the production of inflammatory cytokines while increases the production of anti-inflammatory cytokines during influenza infection with a virus. Findings suggest that melatonin might be used as an adjuvant therapy with antiviral medications to treat influenza-induced pneumonia and COVID-19.
Keywords: COVID-19; TNF-α; Melatonin
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