Acta Scientific Cancer Biology (ASCB) (ISSN: 2582-4473)

Case Report Volume 5 Issue 8

Can Uncontrolled Blood Sugar Trigger Early Presentation of a Long Term Diabetic Complication? A Case Report of Lymphocytic Mastitis in a Recently Diagnosed Diabetic Patient

Zainab Aldawood* and Jamila Alazhri

Breast and Endocrine Section, Department of surgery, King Fahd Specialist Hospital, Dammam, Saudi Arabia

*Corresponding Author: Zainab Aldawood, Breast and Endocrine Section, Department of surgery, King Fahd Specialist Hospital, Dammam, Saudi Arabia.

Received: June 18, 2021; Published: July 13, 2021


Introduction: Lymphocytic mastitis is a condition associated with long term history of insulin dependent diabetes mellitus. It commonly presents as a painless breast mass that can imitate breast cancer both clinically and radiologically. The early recognition of this disease is crucial for appropriate management, especially in occasions where the presentation is unusual and least expected.

Presentation of Case: We report a case of a 32 years old female with a short-standing uncontrolled non- insulin dependent diabetes mellitus and multiple endocrine neoplasm syndrome type I [MEN1], who presented with Lymphocytic mastitis suspicious for breast cancer.

Discussion: The patient had a short history (5 years) of DM compared to the duration described in the literature, and unlike the previously reported cases, her DM was noninsulin dependent and she had MEN 1 syndrome. To our knowledge, no prior reports of lymphocytic mastitis associated with MEN syndrome has been published. We hypothesize that the long term histopathological effect of glycosylation in DM can be accelerated by persistently elevated blood sugar (uncontrolled DM) over a shorter period of time.

Conclusion: Lymphocytic mastitis was believed to be associated with long term history of IDDM. We recommend that LM be considered as a differential diagnosis of a breast mass in patients with IDDM as well as non-IDDM. The history of uncontrolled DM, even for short term, should trigger early suspicion of LM to avoid mismanaging this benign condition as breast cancer. Patients with DM, especially uncontrolled, should be encouraged to periodically examine their breasts for the signs of LM.

Keywords: Lymphocytic Mastitis; Fibrotic Mastopathy; Diabetic Mastopathy; Breast Cancer; Insulin Dependent Diabetes Mellitus


  1. Soler N and Khardori R. “Fibrous disease of the breast, thyroiditis, and cheiroarthropathy in type I diabetes mellitus”. The Lancet 8370 (1984): 193-195.
  2. Campos G C P., et al. “Lymphocytic mastopathy mimicking breast malignancy: a case report”. Radiologia Brasileira 4 (2014): 256.
  3. Bilir B E., et al. “A metabolic syndrome case presenting with lymphocytic mastitis”. Breast Care6 (2012): 493-495.
  4. Selma RV., et al. “Mastopatía diabética: clínica, hallazgos radiológicos y anatomopatológicos y tratamiento”. Radiología4 (2011): 349-354.
  5. Camuto PM., et al. “Diabetic masthopaty. A report of 5 cases and a review of the literature”. Archives of Surgery 135 (2000): 1190-1193.
  6. Neetu G., et al. “Diabetic mastopathy: a case report and literature review”. Case Reports in Oncology2 (2010): 245-251.
  7. Logan W W and Hoffman N Y. “Diabetic fibrous breast disease”. Radiology 3 (1989): 667-670.
  8. Chan H H L., et al. “Lymphocytic mastitis and rheumatoid arthritis”. Journal Hong Kong College of Radiologists 5 (2002): 233-234.
  9. Tomaszewski JE., et al. “Diabetic mastopathy: a distinctive clinicopathologic entity”. Human Pathology7 (1992): 780-786.
  10. Sternberg M., et al. “Connective tissue in diabetes mellitus: biochemical alterations of the intercellular matrix with special reference to proteoglycans, collagens and basement membranes”. Diabete and Metabolisme1 (1985): 27-50.
  11. Pereira M A D Q F., et al. “Fibrous mastopathy: clinical, imaging, and histopathologic findings of 31 cases”. Journal of Obstetrics and Gynaecology Research2 (2010): 326-335.
  12. Alhabshi S M I., et al. “Lymphocytic mastitis mimicking breast carcinoma, radiology and pathology correlation: review of two cases”. The Malaysian Journal of Medical Sciences: MJMS3 (2013): 83.
  13. Williams P H., et al. “Sclerosing lymphocytic lobulitis of the breast”. Clinical Radiology3 (1995): 165-167.
  14. Bayer U., et al. “Bilateral, tumorlike diabetic mastopathy-progression and regression of the disease during 5-year follow up”. European Journal of Radiology3 (1998): 248-253.
  15. “What Does It Mean to Have Dense Breasts?” (2020).
  16. Rzymski P., et al. “Correlation between insulin resistance and breast elasticity heterogeneity measured by shear wave elastography in premenopausal women–a pilot study”. Archives of Medical Science: AMS6 (2011): 1017.
  17. Shaffrey JK., et al. “Diabetic fibrous mastopathy: case reports and radiologic–pathologic correlation”. Breast Journal6 (2000): 414-417.
  18. Sabate JM., et al. “Radiologic evaluation of uncommon inflammatory and reactive breast disorders”. Radiographics 2 (2005): 411-424.
  19. Andrews-Tang DA., et al. “Diabetic mastopathy: adjunctive use of ultrasound and utility of core biopsy in diagnosis”. Breast Journal3 (2000): 183-188.
  20. Goulabchand R., et al. “Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players”. Journal of Clinical Medicine4 (2020): 958.
  21. Sankaye S and Kachewar S. “Diabetic mastopathy”. The Australasian Medical Journal6 (2012): 296.


Citation: Zainab Aldawood and Jamila Alazhri. “Can Uncontrolled Blood Sugar Trigger Early Presentation of a Long Term Diabetic Complication? A Case Report of Lymphocytic Mastitis in a Recently Diagnosed Diabetic Patient". Acta Scientific Medical Sciences 5.8 (2021): 32-36.


Copyright: © 2021 Zainab Aldawood and Jamila Alazhri. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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