Seema Rai* and Suman Rathore

Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India

*Corresponding Author: Seema Rai, Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India.

Received: June 20, 2021; Published: July 13, 2021

Abstract

Melatonin has long been considered to play a crucial role in our interactions with viruses. Influenza, sometimes known as the flu, is an RNA virus-borne infectious illness to play a crucial role in our interactions with viruses. Influenza, sometimes known as the flu, is an RNA virus-borne infectious illness TNF-α, IL-6, and IFN-γ are inflammatory cytokines. IFN-γ inhibits the viral infection. Melatonin therapy dramatically reduces TNF-α, IL-6, and IFN-γ expression while increasing IL-10 and TGF-β production, according to this study. Melatonin promotes the synthesis of IL-10 by upregulating the expression of IL-27 in dendritic cells. Melatonin also decreases the levels of TNF-α in CD8 T cells in a considerable way. Compared to ribavirin alone, melatonin plus ribavirin co-treatment dramatically enhances the lifespan of virus-infected mice. Melatonin therapy decreases the production of inflammatory cytokines while increases the production of anti-inflammatory cytokines during influenza infection with a virus. Findings suggest that melatonin might be used as an adjuvant therapy with antiviral medications to treat influenza-induced pneumonia and COVID-19.

Keywords: COVID-19; TNF-α; Melatonin

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Citation

Citation: Seema Rai and Suman Rathore. “Antiviral Impact of Melatonin with Reference to Influenza Virus and Covid-19 Infection”. Acta Scientific Cancer Biology 5.8 (2021): 09-15.

Copyright

Copyright: © 2021 Seema Rai and Suman Rathore. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.