Seema Rai*, Shonali Chhatar, Shubhada Kalvit and Pravin Kalvit

Department of Zoology, Guru Ghasidas Vishawishvavidyalaya, Koni, Bilaspur, India

*Corresponding Author: Seema Rai, Department of Zoology, Guru Ghasidas Vishawishvavidyalaya, Koni, Bilaspur, India.

Received: June 19, 2021;; Published: July 13, 2021

Abstract

Introduction: Hypothyroidism is a common thyroid disorder. It affects people all over the world irrespective of age, sex, race, and level of wealth and education. Prevalence of hypothyroidism is 2-4% in women in their reproductive age groups. Hypothyroidism can affect fertility due to anovulatory cycles, luteal phase defects, hyperprolactinemia and sex hormone imbalances. The objective of present study is to do an assessment regarding the prevalence of clinical/sub-clinical hypothyroidism in infertile women and the treatment responses for hypothyroidism on infertility.

Methods: A total of 120 infertile women were found who, visited, the infertility clinic for the first time. Reports of clinical parameter such as obtained for, thyroid stimulating hormone (TSH), prolactin (PRL) and estrogen (E₂). Analysis were done at early stage of infertility checkup, instead of straight away going for more expensive tests or invasive procedures. Results: Finding, suggest an increased level of TSH, PRL AND E2 in infertile women of middle age (30 - 40 yrs).

Conclusion: Identification of hypothyroidism and hyperprolactinemia during early and late reproductive stage stages can be preventive in infertile females hence such screening should be mandatory in the primary phage of such females.

Keywords: Thyroid; Hypothyroidism; Hyperprolactinemia; Fertility

References

1. Moon Kyoung Cho., et al. “Thyroid dysfunction and subfertility”. Clinical and Experimental Reproductive Medicine 42 (2015): 131-135.
2. Hymavathi K et al. “Correlation of serum thyroid hormones and prolactin levels to female infertility”. International Journal of Reproduction, Contraception, Obstetrics and Gynecology 5 (2016): 4018-4024.
3. Zhang C., et al. “Effects of 3, 5, 3'-triiodothyronine (t3) and follicle stimulating hormone on apoptosis and proliferation of rat ovarian granulosa cells”. The Chinese Journal of Physiology 56 (2013): 298-305.
4. Aghajanova L., et al. “Thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology”. Fertility and Sterility 95 (2011): 230-237. 237.e1-237.e2.
5. Mishra R., et al. “Prolactin levels in infertility with menstrual irregularities”. Journal of Obstetrics and Gynaecology 52 (2002): 40-43.
6. Prateek Shukla., et al. “Pituitary Hyperplasia in Severe Primary Hypothyroidism: A Case Report and Review of the Literature”. Hindawi Case Reports in Endocrinology (2019): 7.
7. Cooper DS. “Subclinical hypothyroidism”. Advances in Endocrinology and Metabolism 2 (1991): 77.
8. Sudha G., et al. “Causes of female infertility: A cross-sectional study”. International Journal of Latest Research in Science and Technology 2 (2013): 119-123.
9. Shamali J., et al. “Hyperprolactinemia and Its Comparison with Hypothyroidism in Infertile Women”. International Journal of Recent Trends in Science and Technology 8 (2013): 106-108.
10. Avasthi K., et al. “Hyperprolactinema and its correlation with hypothyroidism in infertile women”. Journal of Obstetrics and Gynecology of India 56 (2016): 68-71.

Citation

Citation: Seema Rai., et al. “A Clinical Report on Association of Hypothyroidism and Hyperprolactinemia with Female Fertility”. Acta Scientific Cancer Biology 5.8 (2021): 04-08.

Copyright

Copyright: © 2021 Seema Rai., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.