In-Vivo Photodynamic Therapy Studies in Cancer
Medical Biology Department, Medical Faculty, Sakarya University, Sakarya, Turkey
*Corresponding Author: Süleyman Kaleli, Medical Biology Department, Medical Faculty, Sakarya University, Sakarya, Turkey.
September 16, 2019; Published: April 15, 2021
The traditional surgical method for cancer treatment has not been successful in removing primary or metastatic tumors. Chemotherapy and radiation therapy methods, as well as cancer cells and healthy cells affect the process of treatment nausea, hair loss, immune system weakness, such as there are many side effects. Photodynamic therapy (PDT) is a regulator for the treatment of many malignant carcinomas that can cause immunogenic apoptosis. Despite these adversities in surgery, chemotherapy and radiation therapy, significant progress has been made in PDT research recently. This review article is aimed to present recent studies.
Keywords: Photodynamic Therapy; Cancer Treatment; Metastatic Tumors References
Başoğlu H. “Protoporfirin yüklü Manyetolipozomların Biyofiziksel Karakterizasyonu”. Adnan Menderes Üniversitesi Sağlık Bilimler Enstitüsü Biyofizik Anabilim Dalı (2014).
Gracia-Cazaña T., et al. “Biomarkers of basal cell carcinoma resistance to methyl-aminolevulinate photodynamic therapy”. PLoS One4 (2019): e0215537.
Lan Y., et al. “Combinatory Effect of ALA-PDT and Itraconazole Treatment for Trichosporon asahii”. Lasers in Surgery and Medicine (2020).
Fan L., et al. “Photodynamic therapy for rosacea in Chinese patients”. Photodiagnosis and Photodynamic Therapy 24 (2018): 82-87. Cansevertıpta ZB. “Fotodinamik Tedavi Sonuçlarımız”. Çukurova Üniversitesi Tıp Fakültesi Göz Hastalıkları Anabilim Dalı Uzmanlık Tezi (2018).
Erdem SS., et al. “Skov-3 Over Kanseri Hücre Hattında FotodinamikTerapi UygulamasıKlinik Çalışma Original Article”. Haydarpaşa Numune Medical Journal 3 (2017): 119-112.
Zheng Y., et al. “Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy”. International Journal of Biological Sciences 1 (2016): 120-132.
Tang R., et al. “Nanophotosensitive drugs for light-based cancer therapy: what does the future hold?”. Nanomedicine (Lond.)10 (2017): 1101-1105.
Elliott JT., et al. “Perfusion CT estimates photosensitizer uptake and biodistribution in a rabbit orthotopic pancreas cancer model: a pilot study”. Academic Radiology5 (2015): 572-579.
Cheng Y., et al. “Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy”. Nature Communications 6 (2015): 8785.
Huang HC., et al. “Photodynamic therapy synergizes with irinotecan to overcome compensatory mechanisms and improve treatment outcomes in pancreatic cancer”. Cancer Research5 (2015): 1066-1077.
Agostinis P., et al. “Photodynamic Therapy of Cancer: An Update”. CA: A Cancer Journal for Clinicians 61 (2011): 250-281.
Liu TW., et al. “Matrix metalloproteinase-based photodynamic molecular beacons for targeted destruction of bone metastases in vivo”. Photochemical and Photobiological Sciences 3 (2016): 375-381.
Obata T., et al. “Photodynamic Therapy Using Novel Zinc Phthalocyanine Derivatives and a Diode Laser for Superficial Tumors in Experimental Animals”. Journal of Cancer Therapy 6 (2015): 53-61.
Shemesh CS., et al. “Thermosensitive Liposome Formulated Indocyanine Green for Near-Infrared Triggered Photodynamic Therapy: In Vivo Evaluation for Triple-Negative Breast Cancer”. Pharmaceutical Research 32 (2015): 1604-1614.
Ma X., et al. “Targeted Delivery of 5 Aminolevulinic Acid by Multifunctional Hollow Mesoporous Silica Nanoparticles for Photodynamic Skin Cancer Therapy”. ACS Applied Materials and Interfaces 7 (2015): 10671-10676.
Pereira PM., et al. “The role of galectin-1 in in vitro and in vivo photodynamic therapy with a galactodendritic porphyrin”. European Journal of Cancer 68 (2016): 60-69.
Tarstedt M., et al. “Aminolevulinic acid and methyl aminolevulinate equally effective in topical photodynamic therapy for non-melanoma skin cancers”. Journal of the European Academy of Dermatology and Venereology3 (2016): 420-423.
Ji HT., et al. “5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase”. Molecular Cancer 9 (2010): 91.
Osaki T., et al. “Metformin enhances the cytotoxicity of 5-aminolevulinic acid-mediated photodynamic therapy in vitro”. Oncology Letter1 (2017): 1049-1053.
National Center for Biotechnology Information. PubChem Compound Summary for CID 137321858, Porfimer sodium (2021).
Nwogu C., et al. “Porfimer Sodium Versus PS785 for Photodynamic Therapy (PDT) of Lung Cancer Xenografts in Mice (A Novel Agent for Lung Cancer PDT)”. Journal of Surgical Research 263 (2021): 245-250. Citation