Acta Scientific Cancer Biology (ASCB) (ISSN: 2582-4473)

Review Article Volume 4 Issue 11

Oral Mucosal Membrane Exposure and Adverse Health Risks Due to the Use of Smokeless Tobacco

Gail Cherry-Peppers1*, Andrea D Jackson2, Cheryl Fryer1, Candice Mitchell1, Tanya Greenfield1, Robert Gamble1, Xinbin Gu4, Jezelle Sonnier1, Dorienne Taylor-Bishop1, Gillian Robinson-Warner1, Lisa Slade1, Brian Laurence1, Albert Cheek1, Floydstyne Williams3 and Gretchen Peppers5

1Doctor of Dental Surgery, Office of the Dean, Howard University College of Dentistry, Washington, DC. United States of America
2Dean Andrea Jackson, Howard University College of Dentistry, Washington, DC, United States of America
3Project Coordinator, Howard University College of Dentistry, Washington, DC, United States of America
4Associate Dean for Research, M.D., PhD., Howard University College of Dentistry, Washington, DC, United States of America
5Research Committee Summer Student, Washington, DC, United States of America

*Corresponding Author: Gail Cherry-Peppers, Associate Professor, Department of Restorative Dentistry, Director, Community Services Howard University College of Dentistry, United States of America.

Received: September 17, 2020; Published: October 13, 2020

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Abstract

  Substantial impact of various smokeless tobacco toxicants, constituents, and chemicals as they pass through the oral mucosal tissues, enter body fluids and systems causing adverse health effects. Greater emphasis should be placed on the early cellular, molecular, physiological, and morphological changes that occur secondary to the harmful chemicals and toxicants in smokeless tobacco, which play a role in the carcinogenesis process. Smokeless tobacco constituents may cause destruction and/or irritation of the oral mucosal tissues resulting in severe tissue damage, carcinogenesis and serious systemic effects.

Keywords: Buccal Squamous Cell Carcinoma (OSCC); Buccal Cancer; Global Adult Tobacco Survey (GATS)

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References

  1. Neville BW and Day TA. “Oral cancer and precancerous lesions”. CA: A Cancer Journal for Clinicians 52 (2002): 195-215.
  2. Hatsukami DK., et al. “Changing smokeless tobacco products, new delivery systems”. American Journal of Preventive Medicine 33 (2007): S368-378.
  3. Gupta J., et al. “Smokeless tobacco and oral cancer: a review”. Indian Journal of Oral Science2 (2012): 74-78.
  4. https://oralcancerfoundation.org/facts/
  5. Song MA., et al. “Chemical and toxicological characteristics of conventional and low-TSNA moist snuff tobacco products”. Toxicological Letters 245 (2016): 68-77.
  6. https://www.tobaccofreekids.org/assets/factsheets/0319.pdf
  7. International Agency for Research on Cancer (IARC). “Tobacco smoke and involuntary smoking tobacco and tobacco specific nitrosamines”. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Lyon France: IARC 89 (2007): 33-187.
  8. Hatsukami DK and Severson HH. “Oral spit tobacco: addiction, prevention and treatment”. Nicotine and Tobacco Research 1 (1999): 21-24.
  9. IOM clearing the smoke. “Assessing the science base for tobacco harm reduction”. Washington DC National Academy Press (2001).
  10. Hatsukami DK., et al. “Evidence supporting product standards for carcinogens in smokeless tobacco”. Cancer Prevention Research1 (2015): 20-26.
  11. Stepanov I., et al. “New and traditional smokeless tobacco: Comparison of toxicant and carcinogen levels”. Journal of Nicotine and Tobacco Research 10 (2008): 1773-1782.
  12. Greer RO and Paulson TC. “Oral tissue alterations associated with the use of smokeless tobacco in teenagers part 1”. Journal of Oral Surgery, Oral Medicine, Oral Pathology3 (1983): 275-284.
  13. Federal Register. “Harmful and Potentially Harmful Constituents in Tobacco Products and Smoke; Established list”. Washington, DC; Department of Health and Human Services, Food and Drug Administration 64 (2012): 20034-20037.
  14. Stepanov I and Hatsukami DK. “Call to establish constituent standards for smokeless tobacco products”. Journal of Tobacco Regulatory Standards1 (2016): 9-30.
  15. https://www.statista.com/statistics/1094473/moist-snuff-tobacco-sales-us/
  16. Delnevo CA., et al. “Examining market trends in United States smokeless tobacco use: 2005-2011”. Tobacco Control2 (2014): 107-112.
  17. Winn DM., et al. “Snuff dipping and oral cancer among women in the Southern United States”. New England Journal of Medicine 304 (1981): 745-749.
  18. National Cancer Institute. Smokeless tobacco or health: an international perspective. Smoking and tobacco control monograph no. 2. Publication no. 92-3461. Bethesda, MD: U.S. Department of Health and Human Services, National Cancer Institute (1992).
  19. Tomar SL and Winn DL. “Chewing tobacco use and dental caries among U.S. men”. Journal of the American Dental Association 130 (1999): 1601-1610.
  20. Newell J. “Tobacco use and oral cancer: A global perspective”. Journal of Dental Education4 (2001): 328-339.
  21. https://www.mentalhealth.va.gov/quit-tobacco/docs/Smokeless_Tobacco_A_Guide_for_Quitting_Workbook_508.pdf
  22. cancer.gov/about-cancer/causes-prevention/risk/tobacco/smokeless-fact-sheet
  23. Hirayama T. “Epidemiology of stomach cancer in Japan with special reference to the strategy for primary prevention”. Japanese Journal of Clinical Oncology 14 (1984): 159-168.
  24. Tomar SL and Henningfield JE. “Review of evidence that pH is a determinant of nicotine dosage from oral use of smokeless tobacco”. Tobacco Control 6 (1997): 219-225.
  25. Andersson G and Warfvinge G. “The influence of nicotine concentration in oral moist snuff on mucosal changes and salivary pH in Swedish snuff users”. Swedish Dental Journal 2 (2003): 67-75.
  26. Henningfield JE., et al. “Estimation of available nicotine content of six smokeless tobacco products”. 4.1 Tobacco Control (1995): 57-61.
  27. Richter P and Spierto FW. “Surveillance of smokeless tobacco, nicotine, pH, moisture and unprotonated nicotine content”. Nicotine and Tobacco Research 6 (2003): 885-889.
  28. Hatsukami DK., et al. “Topical features of smokeless tobacco use”. Psychopharmacology 96 (1988): 428-442.
  29. Hoffman D and Djordjevic MV. “Chemical composition and carcinogenicity of smokeless”. Advances in Dental Research3 (1997): 322-329.
  30. Hecht SS., et al. “Induction of oral cavity tumors in F344 rats by tobacco specific nitrosamines and snuff”. Cancer Research8 (1986): 4162-4166.
  31. Hecht SS., et al. “Similar exposure to a tobacco-specific carcinogen in smokeless tobacco users and cigarette smokers”. Cancer Epidemiology Biomarkers Prevention8 (2007): 1567-1572.
  32. Yuan JM., et al. “Urinary levels of the tobacco-specific carcinogen N’nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risks in smokers”. Carcinogenesis9 (2011): 1366-1371.
  33. Stepanov I., et al. “Tobacco specific N’nitrosamine exposure and cancer risks in the Shanghai Cohort study: remarkable coherence with rat tumor sites”. International Journal of Cancer10 (2014): 895-891.
  34. Hecht, SS., et al. “Biochemistry, biology and carcinogenicity of tobacco-specific N-nitrosamines”. Chemical Research Toxicology 11 (1998): 559-603.
  35. Ashrafi SH., et al. “A light transmission and scanning electron microscope study of snuff treated hamster, cheek pouch epithelium”. Scanning Electroscopy 6 (1992): 183-194.
  36. Grasso P and Mann AH. “Smokeless tobacco and oral cancer: An assessment of evidence derived laboratory animals”. Food and Chemistry Toxicology 36 (1998): 1015-1029.
  37. Daniels TE., et al. “Reduction of Langerhans cell in tobacco-associated oral mucosal lesions”. Journal of Oral Pathology and Medicine3 (1992): 100-104.
  38. Warnasulakuriya KAAS and Rahlan R. “Clinical pathological, cellular and molecular lesions caused by oral smokeless tobacco- a review”. Journal of Oral Pathology and Medicine2 (2007): 63-77.
  39. Mohammed MEA and Brima EL. “Cytological changes in oral mucosa induced by smokeless tobacco”. Tobacco Induced Diseased Diseases 17 (2019): 46.
  40. Chambers MS and Jacob RF. “How carcinogens cause cancer”. Texas Dental Journal6 (1994): 13-19.
  41. Kaugars, GE., et al. “Smokeless tobacco use and oral epithelial dysplasia”. Cancer7 (1989): 1527-1530.
  42. Malhotra R., et al. “Nicotine and periodontal dental disease”. Journal of Indian Society of Periodontology1 (2010): 72-79.
  43. Smokeless Global, 2014 National Cancer Institute and Centers for Disease Control and Prevention. "Smokeless tobacco and public health: a global perspective”. Department of Health and Human Services, Centers for Disease Control and Prevention and National Institutes of Health, National Cancer Institute (2014).
  44. Arimilli S., et al. “Combustible cigarette and smokeless tobacco product preparations differentially regulate intracellular calcium mobilization in HL60 cells”. Journal of Inflammation5 (2019): 1641-1651.
  45. Kausar A., et al. “Micronucleus and other nuclear abnormalities among betel quid chewers with or without sadagura, a unique smokeless tobacco preparation from North-East India”. Mutation Research1-2 (2009): 72-75.
  46. Emminger, A and Mohr U. “Cavity, cheek, pouch, salivary glands, esophagus, stomach and intestine”. In: Pathology of Tumors in Laboratory Animals—Part III: Tumors of the Hamster. Edited by VS Turosov. International Agency for Research (IARC), Lyon, (1981).
  47. Ashrafi SH., et al. “A Light Transmission and scanning electron microscope Study of snuff treated hamster, cheek pouch epithelium”. Scanning Electroscopy 6 (1992): 183-194.
  48. Andersson G. “Snuff-induced changes associated with the use of loose and portion-bag-packed Swedish snuff. A clinical, histological, and follow-up study”. Swedish Dental Journal 75 (1991): 1-89.
  49. Marvropoulas A., et al. “The acute effects of smokeless tobacco (snuff) on gingival blood flow in man”. Journal Periodontal Research4 (2001) 221-226.
  50. Proia NK., et al. “Smoking and smokeless tobacco-associated buccal cell mutations and their associations with oral cancer- A review”. Cancer Epidemiology Biomarker Prevention6 (2006): 1061-1077.

 

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Citation

Citation: Gail Cherry-Peppers., et al. “Oral Mucosal Membrane Exposure and Adverse Health Risks Due to the Use of Smokeless Tobacco". Acta Scientific Medical Sciences 4.11 (2020): 10-16.




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