Abstract

 Merkel cell carcinoma (MCC) is a primary neuroendocrine malignancy of the skin, presenting as firm, painless, rapidly growing nodule. MCC often presents in elderly, fair-skinned individuals in sun-exposed areas. Diagnosis is often overlooked at time of presentation due to its rarity, but MCC is twice as deadly as malignant melanoma. MCC are Small round blue cell tumor of uncertain origin and an association with the polyomavirus has been seen in > 80% of MCC. This study present a case of MCC which was initially diagnosed as SCC of skin but Immunohistochemistry revealed the diagnosis of MCC, as stains for CD56, CK20, CK7 and synaptophysin were positive. In addition to surgical excision, the patient also received risk adapted adjuvant therapy as described. This case report and literature review elucidates the clinical, histopathologic and management aspects of MCC, which will help in recognizing and treating these tumors.

Keywords: Merkel Cell Carcinoma (MCC); CD56; CK20; CK7; Synaptophysin

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Citation

Citation: Hemant Pandey., et al. “Merkel Cell Carcinoma, a Case Report, Literature Review and Treatment Updates". Acta Scientific Cancer Biology 4.10 (2020): 03-06.

Copyright

Copyright: © 2020 Hemant Pandey., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.