Kanishka Uthansingh1,2, Sunil Kumar Agarwala3 and Manoj Kumar Sahu1,2*
1Department of Gastroenterology and Hepatology, Institute of Medical Sciences and SUM Hospital, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India
2Molecular Diagnostic and Research Center (MDRC), Institute of Medical Sciences and SUM Hospital, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India
3Department of Surgical Oncology, Institute of Medical Sciences and SUM Hospital, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India
*Corresponding Author: Manoj Kumar Sahu, Professor, Department of Gastroenterology, IMS and SUM Hospital, Siksha O Anusandhan Deemed to be University, Bhubaneswar, Odisha, India.
Received: June 22, 2020; Published: August 24, 2020
Gastric cancer (GC) still one of the most prevalent malignancies across the globe. So far, the majority of research studies have not come up with a proper diagnostic and therapeutic approach which may be due to lack of external validation. Attempts have been undertaken but due to methodological shortcomings and insufficient reporting, the breach between biomarker discovery and its clinical use not been explored. So, there should be an improved systematized tunnel of diagnostic marker approach focusing on correct methodology, quality of support, and emphasis on external validation which could have an impact on better clinical diagnosis and prognostication. This review aimed at the early diagnosis of GC through biomarkers and their potential applications in cellular proliferation, apoptosis, and angiogenesis. Moreover, this review highlights the genetic, epigenetic modifications, signaling pathways, and NGS advancement that could identify the novel therapeutic targets as well as noninvasive biomarkers for therapeutic response.
Keywords: Gastric Cancer (GC); Helicobacter pylori (H. pylori); Epigenetics; MicroRNAs (MiRNA); Next Generation Sequencing (NGS); Microsatellite Instability (MSI); Biomarker
Citation: Manoj Kumar Sahu., et al. “Unveiling the Genomic Landscape of Gastric Cancer Diagnosis, a Snapshot”.Acta Scientific Cancer Biology 4.9 (2020): 09-19.
Copyright: © 2020 Manoj Kumar Sahu., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.