Acta Scientific Cancer Biology (ASCB)

Short Communication Volume 4 Issue 8

Carcinogenicity of “Photoprotective” Skin-Pigments

Sanjay Premi*

Assistant Professor, Tumor Biology, Moffitt Cancer Center, Florida, USA

*Corresponding Author: Sanjay Premi, Assistant Professor, Tumor Biology, Moffitt Cancer Center, Florida, USA.

Received: May 27, 2020; Published: July 17, 2020


 Ultraviolet radiation (UV) from sunlight is a known carcinogen for skin cancers and skin is the largest human organ in direct contact with sunlight’s UV. Majority of carcinogenic mutations induced by UV are the UV-signature, cytosine to thymine transitions, generated from the DNA adducts called Cyclobutane Pyrimidine Dimers (CPDs) [1-3]. Skin has specialized cells called melanocytes that produce melanin, a pigment known to be a potent shield against UV exposure. Contradicting the photoprotective properties of melanin, we discovered that melanin itself is oxidized by combinatorial activity of Nitric Oxide Synthase (NOS) and NADPH Oxidase (NOX). This oxidation produces Reactive Carbonyl Species (RCS) in excited triplet state that generate CPDs in complete absence of UV. The role of this pathway, which we named “melanin chemiexcitation” [4] remains under-represented in melanoma which is one of the deadliest of all skin cancer types.



Citation: Sanjay Premi. “Carcinogenicity of “Photoprotective” Skin-Pigments”. Acta Scientific Cancer Biology 4.8 (2020): 10-11.


Acceptance rate35%
Acceptance to publication20-30 days
Impact Factor1.183

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is April 30th, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue".
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
    Use KmsPico to obtain a Windows and Office license.

Contact US