Acta Scientific Cancer Biology (ASCB)

Review Article Volume 4 Issue 7

Role of Polyphenols like Resveratrol in Cancer Prevention and Treatment-Especially in Combination with Other Polyphenols Like Quercetin-Detailed Mode of Action and Future Perspectives-A Systematic Review

Kulvinder Kochar Kaur1*, Gautam Allahbadia2 and Mandeep Singh3

1Scientific Director, DR Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
2Scientific Director, Rotunda-A Centre for Human Reproduction, Mumbai, India
3Consultant Neurologist, Swami Satyanand Hospital, Jalandhar, Punjab, India

*Corresponding Author: Kulvinder Kochar Kaur, Scientific Director, DR Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India.

Received: March 17, 2020; Published: June 09, 2020

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Abstract

 Earlier having reviewed the role of resveratrol,a polyphenol along with other polyphenols in obesity,DM, autoimmune disease and role of programmed death-1(PD1)/programmed death-ligand1(PD-L1) system in ovarian and other cancers here we decided to carry out a systematic review on role of resveratrol,alone or in combination with other polyphenols in prevention as well as therapy of various cancers like ovarian cancer,breast cancer especially basal cell and HER+ve, besides multiple melanoma, colorectal and other cancers on the basis of senescent cell approach in cancer cells.We found thatPolyphenols inhibit senescent-associated secretory phenotype(SASP) factors secretion from senescent cells to form anti-tumor microenvironment for avoiding cancer.Once tumorigenesis starts, polyphenols are capable of inhibiting cancer by using oncogenes-oxidative stress, DNA Damage response(DDR) as well as endoplasmic reticulum(ER) stress induced cancer senescence. Concomitantly using 2 Polyphenols or a mixture of Polyphenols as well as other anti- cancer drugs increase therapeutic efficacy.This combined use of Polyphenols will be critical in future for this purpose in cancer prevention as well as therapy. .

Keywords: Resveratrol; Polyphenol; Ovarian Cancer; Programmed Death-1(PD1)/Programmed Death-Ligand1 (PD-L1);Breast Cancer; SASP Factors; DDR; SASP Factors

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Citation

Citation: Kulvinder Kochar Kaur., et al. “Role of Polyphenols like Resveratrol in Cancer Prevention and Treatment-Especially in Combination with Other Polyphenols Like Quercetin-Detailed Mode of Action and Future Perspectives-A Systematic Review”.Acta Scientific Cancer Biology 4.7 (2020): 13-20.




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