Acta Scientific Cancer Biology (ASCB)

Review Article Volume 4 Issue 7

Role of Polyphenols like Resveratrol in Cancer Prevention and Treatment-Especially in Combination with Other Polyphenols Like Quercetin-Detailed Mode of Action and Future Perspectives-A Systematic Review

Kulvinder Kochar Kaur1*, Gautam Allahbadia2 and Mandeep Singh3

1Scientific Director, DR Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
2Scientific Director, Rotunda-A Centre for Human Reproduction, Mumbai, India
3Consultant Neurologist, Swami Satyanand Hospital, Jalandhar, Punjab, India

*Corresponding Author: Kulvinder Kochar Kaur, Scientific Director, DR Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India.

Received: March 17, 2020; Published: June 09, 2020



 Earlier having reviewed the role of resveratrol,a polyphenol along with other polyphenols in obesity,DM, autoimmune disease and role of programmed death-1(PD1)/programmed death-ligand1(PD-L1) system in ovarian and other cancers here we decided to carry out a systematic review on role of resveratrol,alone or in combination with other polyphenols in prevention as well as therapy of various cancers like ovarian cancer,breast cancer especially basal cell and HER+ve, besides multiple melanoma, colorectal and other cancers on the basis of senescent cell approach in cancer cells.We found thatPolyphenols inhibit senescent-associated secretory phenotype(SASP) factors secretion from senescent cells to form anti-tumor microenvironment for avoiding cancer.Once tumorigenesis starts, polyphenols are capable of inhibiting cancer by using oncogenes-oxidative stress, DNA Damage response(DDR) as well as endoplasmic reticulum(ER) stress induced cancer senescence. Concomitantly using 2 Polyphenols or a mixture of Polyphenols as well as other anti- cancer drugs increase therapeutic efficacy.This combined use of Polyphenols will be critical in future for this purpose in cancer prevention as well as therapy. .

Keywords: Resveratrol; Polyphenol; Ovarian Cancer; Programmed Death-1(PD1)/Programmed Death-Ligand1 (PD-L1);Breast Cancer; SASP Factors; DDR; SASP Factors



  1. Kulvinder Kochar Kaur., et al. “Advances in the Therapy of Advanced Ovarian Cancer-Special Emphasis on the PD1/PDL1 Pathway”.Current Trends in Biomedical Engineering and Biosciences (2016): 001-003.
  2. Kulvinder Kochar Kaur., et al. “An Update on High Grade Serous Ovarian Carcinoma - A Comprehensive Review”. Acta Scientific Cancer Biology 3(2019): 23-35.
  3. Kulvinder Kochar Kaur.,et al. “Alteration in Natural Killer (NK) cell Function inObesity-correlating with comorbidities development like cancer and type 2diabetes-A minireview”. Journal of Endocrinology 2 (2019): 000140.
  4. Kulvinder Kochar Kaur., et al. “Will Utilization of Resveratrol’s Effects be Practical in Multiple Chronic Inflammatory Diseasesand Autoimmune Diseases: A Detailed Review of its Immune Responses and Further Clinical Development in Humans in Future – ASystematic Review". Acta Scientific Microbiology Special1 (2019): 14-23.
  5. Kulvinder Kochar Kaur., et al. “Role of Nutrients Competition in Immunometabolism - Effects on Immune Responses - A Systematic Review". Acta Scientific Nutritional Health10 (2019): 197-204.
  6. Torre LA., et al. “Ovarian cancer statistics,2018”.CA: A Cancer Journal for Clinicians 4 (2018):284-296.
  7. Fujiwara K., et al. “Paradigm shift in the management strategy for epithelial Ovarian cancer”.American Society of Clinical Oncology Educational book 35 (2016):e247-e257.
  8. Agarwal R and Kaye SB. “Ovarian cancer:strategies for overcoming resistanceto chemotherapy”.Nature Reviews Cancer 7 (2003):502-516.
  9. Nawaz Z., et al. “Therapeutic versatility of resveratrol derivatives”.Nutrients11 (2017).
  10. Kozuki Y., et al. “Resveratrol suppresses hepatoma cell invasion independently of its antiproliferative action”.Cancer Letters 2 (2001):151-156.
  11. Opipari AW Jr., et al. “Resveratrol inducedautophagocytosis in Ovarian cancer cells”. Cancer Research 2 (2004):696-703.
  12. , et al. “Cancerchemopreventive activity of resveratrol,a natural product derived from grapes”.Science275.5297 (1997):218-220.
  13. Gwak H.,et al. “ER stress mediated apoptosis by disruptingN-linked glycosylation of proteins in Ovarian cancer cells”. Cancer Letters 2 (2016):347-353.
  14. Showalter A., et al. “Cytokines inimmunogenic cell death :application for Cancer immunotherapy”.Cytokines 97 (2017):123-132.
  15. , et al. “Immunogenic chemotherapy:sensitizes tumors to check point blockade therapy”.Immunity 44.2 (2016):343-354.
  16. Zhang Y., et al. “Resveratrol induces Immunogenic cell death of human and murine Ovarian carcinoma cells”.Infectious Agents and Cancer14 (2019):27.
  17. Chrétien S., et al. “Beyond PD-1/PD-L1 Inhibition: What the Future Holds for Breast Cancer Immunotherapy”. Cancers (Basel) 11 (2019):E628.
  18. Ali HR., et al. “PD-L1 protein expression in breast cancer is rare, enriched in basal-like tumours and associated with infiltrating lymphocytes”. Annals of Oncology 26 (2015):1488-1493.
  19. Griguolo G., et al. “Interaction of host immunity with HER2-targeted treatment and tumor heterogeneity in HER2-positive breast cancer”. Journal for ImmunoTherapy of Cancer 7 (2019):90.
  20. Yao S., et al. “Advances in targeting cell surface signalling molecules for immune modulation”. Nature Reviews Drug Discovery 12 (2013):130-146.
  21. Adams S., et al. “Pembrolizumab monotherapy for previously untreated, PD-L1-positive, metastatic triple-negative breast cancer: cohort B of the phase II KEYNOTE-086 study”. Annals of Oncology 30 (2019):405-411.
  22. Li X., et al. “Navigating metabolic pathways to enhance antitumour immunity and immunotherapy”. Nature Reviews Clinical Oncology 16 (2019):425-441.
  23. Guo C., et al. “Immunometabolism: A new target for improving cancer immunotherapy”. Advances in Cancer Research 143 (2019):195-253.
  24. Verdura S., et al. “Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumorT cell immunity”.Aging1 (2020):1-27.
  25. “The limited In vitro lifetime of human diploid cell strains”. Experimental Cell Research37 (1965): 614-636.
  26. Kuilman T andMichaloglou C. “The essence of senescence”. Genes and Development 24 (2010): 2463-2479.
  27. SlutskyR and Romero R. “Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor”. Journal of Immunology Research (2019): 3128010.
  28. Hernandez-Segura A and Nehme J. “Hallmarks of Cellular Senescence”. Trends in Cell Biology 28 (2018): 436-453.
  29. Seluanov A andGorbunova V. “Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53”. Molecular and Cellular Biology 21 (2001): 1552-1564.
  30. Zhang J and Patel JM. “Enhanced apoptosis in prolonged cultures of senescent porcine pulmonary arteryendothelial cells”. Mechanisms of Ageing and Development 123 (2002): 613-625.
  31. WatanabeS and Kawamoto S. “Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases”. Cancer Science 108 (2017): 563-569.
  32. Roche A and Ross E. “Representative literature on the phytonutrients category: Phenolic acids”. Critical Reviews in Food Science and Nutrition 57 (2017): 1089-1096.
  33. JiS and Zheng Z. “Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells”. Experimental Cell Research 370 (2018): 292-302.
  34. TeponnoRB andKusariS. “Recent advances in research on lignans and neolignans”. Natural Product Reports 33 (2016): 1044-1092.
  35. MalekiSJ and Crespo JF. “Anti-inflammatory effects of flavonoids”. Food Chemistry 299 (2019): 125124.
  36. Zamin LL and Filippi-ChielaEC. “Resveratrol and quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells”. Cancer Science 100 (2009): 1655-1662.
  37. Filippi-ChielaEC andThome MP. “Resveratrol abrogates the temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the temozolomide-induced senescence in glioma cells”. BMC Cancer 13 (2013): 147.
  38. Sprouse AA and Herbert BS. “Resveratrol augments paclitaxel treatment in MDA-MB-231 and paclitaxel-resistant MDA-MB-231 breast cancer cells”. Anticancer Research 34 (2014): 5363-5374.
  39. Zhu Y and HeW. “Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells”. Scientific Reports 5 (2015): 17730.
  40. Luo H and WangL. “Resveratrol enhances ionizing radiation-induced premature senescence in lung cancer cells”. International Journal of Oncology 43 (2013): 1999-2006.
  41. BhardwajA and Sethi G. “Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistancethrough down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells”. Blood 109 (2007): 2293-2302.
  42. SongNR and Chung MY. “Quercetin suppresses invasion and migration of H-Ras-transformed MCF10Ahuman epithelial cells by inhibiting phosphatidylinositol 3-kinase”. Food Chemistry142 (2014): 66-71.
  43. GuoY and Ayers JL. “Senescence-associated tissue microenvironment promotes colon cancer formation throughthe secretory factor GDF15”. Aging Cell 18 (2019): e13013.
  44. Menicacci B andMargheriF. “Chronic Resveratrol Treatment Reduces the Pro-angiogenic E_ect of HumanFibroblast “Senescent-Associated Secretory Phenotype” on Endothelial Colony-Forming Cells: The Role ofIL8”. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 74 (2019): 625-633.
  45. PerrottKM and WileyCD. “Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells”. Geroscience39 (2017): 161-173.
  46. LiuS and Zheng Z. “Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-kappaBpathway in gut of the annual fish Nothobranchiusguentheri”. Fish and Shellfish Immunology80 (2018): 473-479.
  47. Serrano M and Lin AW. “Oncogenic ras provokes premature cell senescence associated with accumulation ofp53 and p16INK4a”. Cell 88 (1997): 593-602.
  48. PanHC and Jiang Q. “Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells”. Neurochemistry International 80 (2015): 60-71.
  49. RusinM andZajkowicz, A. “Resveratrol induces senescence-like growth inhibition of U-2 OS cells associatedwith the instability of telomeric DNA and upregulation of BRCA1”. Mechanisms of Ageing and Development 130 (2009): 528-537.
  50. Bian Y.,etal. “Natural phenolstargeting senescence:a novel prevention and therapy of cancer”.International Journal of Molecular Sciences21 (2020):684.


Citation: Kulvinder Kochar Kaur., et al. “Role of Polyphenols like Resveratrol in Cancer Prevention and Treatment-Especially in Combination with Other Polyphenols Like Quercetin-Detailed Mode of Action and Future Perspectives-A Systematic Review”.Acta Scientific Cancer Biology 4.7 (2020): 13-20.


Acceptance rate35%
Acceptance to publication20-30 days
Impact Factor1.183

Indexed In

News and Events

Contact US