Acta Scientific Cancer Biology (ASCB)

Review Article Volume 4 Issue 7

Role of DNA Mismatch Repair in Cancer

Ganguli D*

Department of Biochemistry, Indian Institute of Science, India

*Corresponding Author: Ganguli D, Department of Biochemistry, Indian Institute of Science, India.

Received: April 08, 2020; Published: June 03, 2020

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Abstract

 DNA mismatch repair (MMR) specifically recognizes and removes mismatched base pairs and small insertion-deletion loops (IDLs) from the genome thereby maintaining the genomic integrity. Deficiency or complete loss of MMR in human leads to different kinds of cancer. The most common cancer associated with MMR deficiency is Hereditary Nonpolyposis Colorectal Cancer (HNPCC) or Lynch syndrome. In addition to this, MMR deficiency has been found to be correlated with other types of cancer, as well. Loss of MMR functions increases the frameshift mutations in different tumor suppressor genes leading to cancer in a tissue dependent manner. In this review, the role of MMR in the development and prognosis of different types of cancer has been discussed. .

Keywords: DNA Mismatch Repair (MMR); Hereditary Nonpolyposis Colorectal Cancer (HNPCC)

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Citation

Citation: Ganguli D. “Role of DNA Mismatch Repair in Cancer”.Acta Scientific Cancer Biology 4.7 (2020): 09-12.




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