Acta Scientific Cancer Biology (ASCB)

Review Article Volume 4 Issue 6

Sulforaphane: Mechanisms of Epigenetic Reversion and its Anti-Carcinogenic Pathways as Potential Adjunctive Treatment in Cancer

Andre da Silva Santos1,2, Sandra Maria Matta3,4* and Henry Okigami5

1Medical Director, Clinical Oncologist at the Center for Integrative Oncology and Prevention (COIP), São Paulo, Brazil
2Scientific Director of G8 Integrative, São Paulo, Brazil
3Nutrigeneticist and Registered Dietitian, Clinical Oncologist at the Center for Integrative Oncology and Prevention (COIP), São Paulo, Brazil
4Scientific Director in Nutrition/Nutritional Genomics/Oncogenetic of G8 Integrative, São Paulo, Brazil
5Director of Science and Technology, Pharmaceutical Biochemist at the Center for Integrative Oncology and Prevention (COIP), São Paulo, Brazil

*Corresponding Author: Sandra Maria Matta, Nutrigeneticist and Registered Dietitian, Clinical Oncologist at the Center for Integrative Oncology and Prevention (COIP), São Paulo, Brazil.

Received: February 29, 2020; Published: May 29, 2020



 Estimates of cancer in Brazil and the salty world each year, placing it at the top of the death causes ranking.
The first and last year of 2007 was 7.6 million in 2007, showing a 32% increase in deaths between 2000 and 2007. In 2007, the cancer was responsible for 13% of all deaths in the world [1,2].
Like what is in Brazil, what is a more common cause of death, the elimination of accidents and cerebrovascular disease. In 2014, 395,000 new cases of cancer were found, 205,000 in men and 190,000 in women. The most incident types of cancer are prostate, lung, colon and rectum. In women, the most common cancers are breast, colon and rectum, cervix, lung and thyroid, according to INCA data. Estimate 2014: Incidence of Cancer in Brazil. 2014; Rio de Janeiro: INCA, 124p.
This is a challenge to prevent the preventive decision of the prevention of the risk of the treatment of treatment and treatment of debilitating disease.
Thus, sulforaphane (SFN) is a natural isothiocyanate derived from cruciferous vegetables, such as broccoli, cabbage, watercress, arugula, kale, etc.
This phytoactive product (isothiocyanate) acts in cellular destiny through the nutritionist dietitian, although after an observation that dietetics are not detected in the urine is an indication that they are not absorbed [3]. In addition, there are sessions available so that the apparatus cannot convert glycosinolates to isothiocyanates [4]. However, they include literacy shows that glycosinolates dietetic they best converted in isothiocyanates in animals and humans, and that this migration is mediated by the activity of myrosinase of the enteric microflora [3,5,6]. Once generated, isothiocyanates are absorbed and metabolized by sequential enzyme waves, a first of which is a conjugation with glutathione [7,8].

Keywords: Sulforaphane (SFN); Isothiocyanate; Cancer



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Citation: Sandra Maria Matta., et al. “Sulforaphane: Mechanisms of Epigenetic Reversion and its Anti-Carcinogenic Pathways as Potential Adjunctive Treatment in Cancer”.Acta Scientific Cancer Biology 4.6 (2020): 21-25.


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