Acta Scientific Cancer Biology

Literature ReviewVolume 2 Issue 3

GLP-1 Receptor Agonists and Cancers

Aqsa Iqbal1* and Anum Iqbal2

1Physiology and Biophysics Department, University of Illinois at Chicago, USA
1Liaquat University of Medical and Health Sciences, Pakistan

*Corresponding Author: Aqsa Iqbal, Physiology and Biophysics Department, University of Illinois at Chicago, USA. E-mail:

Received: March 21, 2018; Published: April 06, 2018

Citation: Aqsa Iqbal and Anum Iqbal. “GLP-1 Receptor Agonists and Cancers”. Acta Scientific Cancer Biology 2.3 (2018).


  Diabetes mellitus is associated with various types of cancers and presence of diabetes as a co-morbidity worsens the prognosis of cancer [1]. Glucagon-like peptide-1 receptor agonist (GLP-1RA) is a class of drug, which is used as a treatment of type 2 diabetes. Studies linking GLP-1RAs with cancers have found that GLP-1 RAs are associated with increased risks of pancreatic and thyroid can- cers and decreased risks of breast, prostate, endometrial, colon, ovarian cancers and various other cancers. This review discusses the impact of GLP-1RAs on different cancers and pathways involved in carcinogenic and anti-carcinogenic effects of GLP-1RAs. GLP-1RAs exerts their carcinogenic and anti-carcinogenic effects by attenuating various pathways including mTOR, ERK ½, and MAPK. Studying and understanding core pathways of GLP-1RAs directs more research on GLP-1RAs and guides the future management of diabetes mellitus.

Keywords: Diabetes Mellitus; Pancreatitis; Glucagon-like receptor agonists (GLP-RAs); Pancreatitis; Insulin; Pancreatic Cancer; Breast Cancer; Prostate Cancer; Endometrial Cancer; Ovarian Cancer; Thyroid Cancer; Exenatide; Liraglutide; Exendin -4; MAPK; mTOR; Akt; Apoptosis; Carcinogenic; Anti-carcinogenic

Copyright: © 2018 Aqsa Iqbal and Anum Iqbal. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Member In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for March Issue
    The last date for submission of articles for regular Issues is March 10, 2020.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US