Abhishek Purkayastha¹*, Neelam Sharma², Arti Sarin³, Sharad Bhatnagar², Nilotpal Chakravarty²,Virender Suhag², Kavita Sahai⁵ ,Abhishek Pathak⁶, Mayuri Jain², Rekha Vashisth² ,Abhishek Dwivedi⁷

¹Department of Radiation Oncology, Command Hospital (Southern Command), Pune, India
²Department of Radiation Oncology, Army Hospital Research & Referral, New Delhi, India
³Department of Radiation Oncology, INHS Asvini, Mumbai, India
⁴Department of Radiation Oncology, Command Hospital (Central Command), Lucknow, India
⁵Department of Onco-Pathology and Molecular Sciences, Army Hospital Research & Referral, New Delhi, India
⁶Department of Medical Oncology, Army Hospital Research & Referral, New Delhi, India
⁷Department of Radiodiagnosis, Base Hospital, New Delhi, India

*Corresponding Author: Abhishek Purkayastha, Department of Radiation Oncology, Command Hospital (Southern Command), Pune, Maharashtra, India.

Received: January 24, 2018; Published: February 09, 2018

Citation: Abhishek Purkayastha., et al. “Primary Non-Hodgkin Lymphoma Diffuse Large B-Cell Type of Skeletal Muscles: An Extremely Rare Case with Review of Literature”. Acta Scientific Cancer Biology 2.2 (2018).

Abstract

  Non-Hodgkin lymphoma (NHL) usually presents with generalized lymphadenopathy involving organs with lymphoid tissue, however extra-nodal presentation is very rare. Primary extra-nodal NHL of skeletal muscles is extremely unusual accounting for only 0.1% of all lymphoma cases. We report such a case in a 54-year-old female who presented with right calf swelling of one year duration. Clinical and radiological evaluation showed a soft tissue lesion involving right calf muscles. Metastatic work-up with positron emission tomography scan was negative and suggestive of primary right calf muscles and biopsy from it revealed Diffuse Large B-Cell lymphoma (DLBCL) confirmed on immunohistochemistry. She was treated with systemic chemotherapy followed by local radiotherapy to which she responded symptomatically. Only few cases-reports have been published in world literature till date regarding primary NHL of skeletal muscles. We report this case with review of literature in view of its extreme rarity, unusual presentation, clinical significance and overall prognosis.

Keywords: Primary Non-Hodgkin Lymphoma; Extra-Nodal; Skeletal Muscles; Radiotherapy

Copyright: © 2018 Abhishek Purkayastha., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.