Alexander A Bukhvostov, Anton S Dvornikov, Kirill V Ermakov and Dmitry A Kuznetsov*

Interfaculty Group for Cellular and Molecular Oncology Studies, N. I. Pirogoff Russian National Research Medical University, Moscow, Russian Federation, www.rsmu.ru, Russia

*Corresponding Author: D A Kuznetsov, Interfaculty Group for Cellular and Molecular Oncology Studies, N I Pirogoff Russian National Research Medical University, Moscow, Russian Federation, www.rsmu.ru, Russia.

Received: June 14, 2017; Published: August 15, 2017

Citation: Dmitry A Kuznetsov., et al. “Bivalent Metal Paramagnetics to Suppress the DNA Polymerase Beta in Human Retinoblastoma Cells. A Caution”. Acta Scientific Cancer Biology 1.1 (2018).

Abstract

  Nuclear spin possessing isotopes (²⁵Mg, ⁴³Ca, ⁶⁷Zn) promote the marked magnetic isotope effects (MIE) on DNA Polymerase Beta (DNApolB) in ex vivo survived human retinoblastoma (RB) cells. In Aphidicolin chase experiment, the RB in situ catalytic activity of DNApolB has been selectively estimated as a function of MIE. A resulted enzyme function breakdown leads to a sharp decrease of cancer cell viability. This study a paramagnetic chemotherapy path is all about.

Keywords: DNA Polymerase Beta, Aphidicolin, retinoblastoma, paramagnetic

Copyright: © 2018 Dmitry A Kuznetsov., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.