Acta Scientific Biotechnology

Review Article Volume 4 Issue 6

Ajuga parviflora: A Comprehensive Review on Botanical, Phytochemical, and Pharmacological Aspects

Sushmita Dwivedi*

Ph.D. Research Scholar, Department of Biotechnology, Govind Ballabh Pant Institute of Engineering and Technology, Ghurdauri, Pauri, Uttarakhand, India <>

*Corresponding Author: Sushmita Dwivedi, Ph.D. Research Scholar, Department of Biotechnology, Govind Ballabh Pant Institute of Engineering and Technology, Ghurdauri, Pauri, Uttarakhand, India.

Received: December 12, 2023; Published: December 22, 2023

Abstract

Ajuga parviflora Benth. (Lamiaceae) is a herbaceous medicinal plant that has a rich tradition of use in various regions of Uttarakhand, India, for treating a range of human ailments, including cough, vaginal discharge, muscle aches, and stomach problems. This plant exhibits diverse pharmacological properties, including antifungal, antibacterial, insecticidal, hypoglycemic, and hepatoprotective activities. Numerous compounds have been isolated from A. parviflora, demonstrating a wide array of biological and pharmacological effects. This comprehensive review offers scientific insights into the bioactive components of the medicinal plant A. parviflora, its pharmacological attributes, and its applications in pharmaceuticals and medicine.

Keywords: Ajuga parviflora; Medicinal Plant; Bioactive Compounds; Pharmaceuticals; Medicine

References

  1. Ayeleso T B., et al. “Oleanolic acid and its derivatives: biological activities and therapeutic potential in chronic diseases”. Molecules 22 (2017): 1915.
  2. Bakrim S., et al. “Health benefits and pharmacological properties of stigmasterol”. Antioxidants 11 (2022): 1912.
  3. Beauchamp P S., et al. “Neo-clerodane diterpenoids from Ajuga parviflora”. Phytochemistry 43 (1996): 827-834.
  4. Bremner P D., et al. “Neo-clerodane diterpenoid insect antifeedants from Ajuga reptans cv catlins giant”. Phytochemistry 47 (1998): 1227-1232.
  5. Burki S., et al. “GC/MS assisted phytochemical analysis of Ajuga parviflora leaves extract along with anti-hepatotoxic effect against anti-tubercular drug induced liver toxicity in rat”. Pakistan Journal of Pharmaceutical Sciences (2020): 33.
  6. Burki S., et al. “Phytochemical, acute toxicity and renal protective appraisal of Ajuga parviflora hydromethanolic leaf extract against CCl4 induced renal injury in rats”. BMC Complementary Medicine and Therapies 21 (2021): 1-14.
  7. Camps F and J J P Coll. “Insect allelochemicals from Ajuga plants”. Phytochemistry 32 (1993): 1361-1370.
  8. Cantrell C L., et al. “Antimycobacterial ergosterol-5, 8-endoperoxide from Ajuga remota”. Planta Medicine 65 (1999): 732-734.
  9. Castro A., et al. “neo-Clerodane Diterpenoids from Ajuga macrosperma var. breviflora”. Natural Product Communications 10 (2015): 1934578X1501000614.
  10. Castro A and J J N P C Coll. “Neo-Clerodane Diterpenoids from Verbenaceae: Structural Elucidation and Biological Activity”. Natural Product Communications 3 (2008): 1934578X0800300630.
  11. Chandra K., et al. “Herbal-based traditional medicinal knowledge of local inhabitants in Rudraprayag district of Uttarakhand, India”. Ethnobotany Research and Applications (2013).
  12. El-Hilaly J., et al. “Vasorelaxant effect of the aqueous extract of Ajuga iva in rat aorta”. Journal of Ethnopharmacology 93 (2004): 69-74.
  13. Gairola S., et al. “A cross-cultural analysis of Jammu, Kashmir and Ladakh (India) medicinal plant use”. Journal of Ethnopharmacology 155 (2014): 925-986.
  14. Guo P., et al. “Bioactive neo-clerodane diterpenoids from the whole plants of Ajuga ciliata Bunge”. Journal of Natural Products 74 (2011): 1575-1583.
  15. Guruprasad B., et al. “Assessment of repellency and insecticidal activity of Ajuga parviflora (Benth) and Trichilia connaroides (W&A) leaf extracts against stored product insects”. Journal of Entomology and Zoology Studies 2 (2014): 221-226.
  16. Israili Z H and B J P J o P S Lyoussi. “Ethnopharmacology of the plants of genus Ajuga”. Pakistan Journal of Pharmaceutical Sciences 22 (2009).
  17. Kariba R M J F. “Antifungal activity of Ajuga remota”. Fitoterapia 72 (2001): 177-178.
  18. Khan P M., et al. “Ajugins C and D, new withanolides from Ajuga parviflora”. Helvetica 82 (1999): 1423-1426.
  19. Krishna Kumari G., et al. “Antifeedant and growth inhibitory effects of some neo-clerodane diterpenoids isolated from Clerodendron species (Verbenaceae) on Earias vitella and Spodoptera litura”. Journal of Agricultural and Food Chemistry 51 (2003): 1555-1559.
  20. Kubo I., et al. “Structure of ajugarins”. Journal of the Chemical Society, Chemical Communications (1976): 949-950.
  21. Kunwar R M., et al. “Ajuga brachystemon Maxim. Ajuga parviflora Benth. in Wall. L amiaceae”. Ethnobotany of the Himalayas (2021): 177-181.
  22. Kuria K., et al. “Antimalarial activity of Ajuga remota Benth (Labiatae) and Caesalpinia volkensii Harms (Caesalpiniaceae): in vitro confirmation of ethnopharmacological use”. Journal of Ethnopharmacology 74 (2001): 141-148.
  23. Maher S., et al. “Isolation of antidiabetic withanolides from Withania coagulans Dunal and their in vitro and in silico validation”. Biology 9 (2020): 197.
  24. Malinowska M., et al. “New lupeol esters as active substances in the treatment of skin damage”. Plos One 14 (2019): e0214216.
  25. Manguro L O A., et al. “Flavonol and iridoid glycosides of Ajuga remota aerial parts”. Phytochemistry 67 (2006): 830-837.
  26. Mehdi K., et al. “Green Synthesis of Silver Nanoparticles using Ajuga parviflora Benth and Digera muricata Leaf extract: Their Characterization and Antimicrobial Activity”. Revista de Chimie (Rev. Chim.) 71 (2020): 50-57.
  27. Muhammad P., et al. “New acetylated quinols from Ajuga parviflora”. Fitoterapia 70 (1999): 229-232.
  28. Nawaz H R., et al. “Ajugin E and F: two withanolides from Ajuga parviflora”. Phytochemistry 52 (1999): 1357-1360.
  29. Nawaz H R., et al. “Chemical constituents of Ajuga parviflora”. Zeitschrift für Naturforschung B 55 (2000): 100-103.
  30. Ogura M., et al. “Potential anticancer agents”. IV. Constituents of Jacaranda caucana Pittier (Bignoniaceae)”. Lloydia 40 (1977): 157-168.
  31. Rahman N., et al. “Phytochemical, antimicrobial, insecticidal and brine shrimp lethality bioassay of the crude methanolic extract of Ajuga parviflora Benth”. Pakistan Journal of Pharmaceutical Sciences 26 (2013): 751-756.
  32. Rana C., et al. “Ethnopharmacology of some important medicinal plants of Nanda devi national park, Uttarakhand, India”. Nature and Science 8 (2010): 9-14.
  33. Rashed K J J S I T. “Beta-sitosterol medicinal properties: A review article”. IJSIT 9 (2020): 208-212.
  34. Sharma A and M Udayabanu. “Screening of hydroalcoholic leaf extract of Ajuga parviflora for antidiabetic potential” (2018).
  35. Suryavanshi A., et al. “Chemical composition, antioxidant and enzyme inhibitory properties of Ajuga parviflora Benth”. Biocatalysis and Agricultural Biotechnology 37 (2021): 102191.
  36. Vanyolos A., et al. “C-29 ecdysteroids from Ajuga reptans var. reptans”. Journal of Nature Production 72 (2009): 929-932.
  37. Yousaf T., et al. “Phytochemical profiling and antiviral activity of Ajuga bracteosa, Ajuga parviflora, Berberis lycium and Citrus lemon against Hepatitis C Virus”. Microbial Pathogenesis 118 (2018): 154-158.

Citation

Citation: Sushmita Dwivedi, et al. “Ajuga parviflora: A Comprehensive Review on Botanical, Phytochemical, and Pharmacological Aspects".Acta Scientific Biotechnology 4.6 (2023): 11-17.

Copyright

Copyright: © 2023 Sushmita Dwivedi, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate33%
Acceptance to publication20-30 days

Indexed In



News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US