Acta Scientific Biotechnology

Mini Review Volume 4 Issue 1

Hereditary Obesity: Causes and Genetic Relevance

Ayesha Javed*

Department of Biochemistry and Molecular Biology, Pondicherry University, St. Francis College for Women, India

*Corresponding Author: Ayesha Javed, Department of Biochemistry and Molecular Biology, Pondicherry University, St. Francis College for Women, India.

Received: November 28, 2022; Published: December 22, 2022

Abstract

Obesity is a multi-featured disease characterized by an abnormal rise in body fat content, owing to several factors which cannot be traced down to a single determinant but often a combination of them. The article discusses these causes which are broadly classified as biological, environmental, and behavioral factors. Biological factors are supplemented by metabolic modifications of the normal body cycle, which include genetics, gut microbiota (loss or gain of some species may impair fat metabolism or absorption), hormonal effects (for instance steroid hormones are closely related to acquiring an obese body), use of medications and alcohol consumption. On the other hand, environmental effects encompass the societal or cultural ambiance, presence of certain obesity-related chemicals, and obesogenic environment (surroundings encouraging weight gain and unfavorable to loss of weight). Sedentary lifestyles and inadequate exercise correspond to behavioral factors [4]. Genetic factors are the highlight of the article, which reviews various genes related to conferring obesity, the associated complications, and possible solutions.

Keywords: Obesity; Hereditary Obesity; Genetics; BMI

References

  1. World Health Organisation. “Obesity and overweight” (2021).
  2. Singh RK., et al. “Molecular genetics of human obesity: A comprehensive review”. Comptes Rendus Biologies 2 (2017): 87-108.
  3. Canoy D and Bundred P. “Obesity in children”. BMJ Clinical Evidence (2011).
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  5. Wardle J., et al. “Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment”. The American Journal of Clinical Nutrition 2 (2008): 398-404.
  6. Mahmoud R., et al. “Genetics of Obesity in Humans: A Clinical Review”. International Journal of Molecular Sciences 23 (2022): 11005.
  7. Karra E., et al. “A link between FTO, ghrelin, and impaired brain food-cue responsivity”. Journal of Clinical Investigation 8 (2013): 3539-3551.
  8. Pi-Sunyer FX. “The Obesity Epidemic: Pathophysiology and Consequences of Obesity” (2002).
  9. Alex Haley. “Is Obesity Genetic? Can it be Passed on through Generations”. (2022).

Citation

Citation: Ayesha Javed. “Hereditary Obesity: Causes and Genetic Relevance".Acta Scientific Biotechnology 4.1 (2023): 16-19.

Copyright

Copyright: © 2022 Ayesha Javed. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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Acceptance rate33%
Acceptance to publication20-30 days

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