Acta Scientific Biotechnology

Review Article Volume 3 Issue 3

Appraisal of Isoflurane and Sevoflurane

A Mohamed Skkander*

Department of Chemistry, Velammal Engineering College, Chennai, India

*Corresponding Author: A Mohamed Skkander, Department of Chemistry, Velammal Engineering College, Chennai, India.

Received: May 4, 2022; Published: May 18, 2022


Isoflurane and Sevoflurane are inhalational anesthetics that belong to the halogenated ether group. They are used to induce and maintain general anesthesia. Isoflurane is currently approved for use in dogs, cats, horses, ornamental birds, reptiles, and small mammals such as rabbits in the United Kingdom, but sevoflurane is exclusively approved for use in dogs. Both have similar adverse effects, such as central nervous system depression, respiratory depression, myocardial depression, depression of body temperature regulating centers, hypotension, vasodilatation, and muscle relaxation. Both drugs can lower cerebral metabolic rate and produce vasodilatation leading to a rise in cerebral pressure. In patients with head trauma and/or cerebral pathology, this should be continuously monitored, and it may be required to ventilate them to keep carbon dioxide levels at an adequate level to prevent a further rise in cerebral pressure. When given equal amounts of sevoflurane and isoflurane, a group of dogs experienced less respiratory depression. In terms of total side effects, both are the same and therefore one agent is better than the other.

Keywords: Hypotension; Central Nervous System Depression; Respiratory Depression; Depression of Body Temperature; Muscle Relaxation; Cerebral Pressure


  1. Mariana Gaya da Costa., et al. “Inhaled Anesthetics: Environmental Role, Occupational Risk, and Clinical Use”. Journal of Clinical Medicine 6 (2021): 1306.
  2. Watts N., et al. “The 2019 report of The Lancet Countdown on health and climate change: Ensuring that the health of a child born today is not defined by a changing climate”. Lancet 394 (2019): 1836-1878.
  3. Katharina Hohlbaum., et al. “Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice Assessing the degree of distress”. PLoS One6 (2017): e0179588.
  4. Meysam Hashemi., et al. “Anesthetic action on extra-synaptic receptors: effects in neural population models of EEG activity”. Frontiers in Systems Neuroscience (2014).
  7. Deng J., et al. “Neuroprotective gases--fantasy or reality for clinical use?” Progress in Neurobiology 115 (2014): 210-245.
  8. Brown EN., et al. “General Anesthesia: Theory and Practice”. Anesthesia and Analgesia5 (2018): 1246-1258.
  9. Aranake A., et al. “Minimum alveolar concentration: ongoing relevance and clinical utility”. Anaesthesia 5 (2013): 512-522.
  10. Brosnan RJ. “Inhaled anesthetics in horses”. Veterinary Clinics of North America: Equine Practice 1 (2013): 69-87.
  11. Scheiermann P., et al. “Intravenous versus inhalational anesthesia for pediatric inpatient surgery - A systematic review and meta-analysis”. Journal of Clinical Anesthesia 49 (2018): 19-25.


Citation: A Mohamed Skkander. “Appraisal of Isoflurane and Sevoflurane".Acta Scientific Biotechnology 3.3 (2022): 05-08.


Copyright: © 2022 A Mohamed Skkander. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate33%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is May 30, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US