Acta Scientific Biotechnology

Editorial Volume 3 Issue 2

Drugs Induced Hepatotoxicity

Rajesh Kumar*

Department of Biosciences, Himachal Pradesh University, Shimla, India

*Corresponding Author: Rajesh Kumar, Department of Biosciences, Himachal Pradesh University, Shimla, India.

Received: March 23, 2022; Published: March 30, 2022

Liver, the largest gland of the human body, is the main metabolic organ restricted within the area of right lower rib cage underneath the diaphragm and inhabits mainly hypochondriac region and some part of the epigastric regions of the abdomino-pelvic cavity. Liver is divided into large right and small left lobe which are separated through falciform ligament. Inside the open periphery of falciform ligament there is presence of ligamentum teres also called round ligament of the liver [1]. It is a fibrous cord like structure extended from the liver to umbilicus. Below the caudate lobe, a deep fissure called porta hepatis is situated which is the entry point of hepatic artery and vein into the liver. Portal vein is responsible for the transportation of blood along with nutrients from the digestive system. Bile duct is present inferior to the porta hepatis which leads back to the gallbladder. Certain physiological processes including metabolism, detoxification, synthesis, secretion, biotransformation and storage are regulated by liver. A number of substances are processed and synthesized inside the liver which are then transported towards different parts of the body to perform numerous metabolic functions. As a result of important role in various metabolic functions, it is believed that liver also perform fat, protein and carbohydrate metabolism [2].

References

  1. GJ Tortora and BH Derrickson. “Principles of Anatomy and Physiology”. John Wiley and Sons (2008).
  2. AC Guyton and JE Hall. Medical Physiology (2006) 3.
  3. LB Seeff. “Herbal hepatotoxicity” Clinical Liver Disease (2007): 577-596.
  4. AM Schoepfer., et al. “Hepatotoxicity associated with dietary supplements from Herbalife products”. Journal of Hepatology 47 (2007) 521-526.
  5. A Alton-Lee. “Quality teaching for diverse students in schooling: Best evidence synthesis”. (2003).
  6. R Temple and M Himmel. “Safety of newly approved drugs: implications for prescribing”. JAMA 287 (2002): 2273-2275.
  7. T Li and J Chiang. “Bile acid signaling in metabolic disease and drug therapy”. Pharmacology Review 66 (2014): 948-983.
  8. SA Salim. “A study of hepatoprotective effects of Curcuma Xanthorrhiza and Ipomoea Aquatica on thioacetamide-induced liver cirrhosis in rats” (2013).
  9. K Thanki., et al. “Oral delivery of anticancer drugs: challenges and opportunities”. Journal of Controlled Release 170 (2013): 15-40.

Citation

Citation: Rajesh Kumar. “Drugs Induced Hepatotoxicity".Acta Scientific Biotechnology 3.2 (2022): 01-02.

Copyright

Copyright: © 2022 Rajesh Kumar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate33%
Acceptance to publication20-30 days

Indexed In



News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 15, 2022.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US