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Acta Scientific Biotechnology

Short Communication Volume 1 Issue 12

Molecular Targets and Biotechnological Exploration on Corona-Virus and Multi-Drug Resistant Bacteria

Asit Kumar Chakraborty*

Associate Professor of Biochemistry, OIST, Department of Biotechnology, Vidyasagar University, Midnapore, West Bengal, India

*Corresponding Author: Asit Kumar Chakraborty, Associate Professor of Biochemistry, OIST, Department of Biotechnology, Vidyasagar University, Midnapore, West Bengal, India.

Received: November 25, 2020; Published: November 30, 2020

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  Invisible SARS-CoV-2 27kb single (+)-stranded RNA virus (120nm) has crossed limit by killing 3 millions and affecting 600 millions [1]. Severe COVID-19 is more common in adults aged ~70 years and older and in individuals with comorbidities such as hypertension, diabetes, cardiovascular disease, and chronic respiratory disease [2]. Indian Government as well as other G-20 nations declared war against Corona virus. Coronavirus has structural proteins (S, M, N, E) and two large polyproteins which degraded into sixteen non-structural proteins (nsp1-16) [3]. No new targeted drug was discovered and vaccine is only new hope. Presently, at least ten vaccine candidates are in stage-III clinical trials on 20 - 40 thousand human worldwide [4-8]. It is expected that India should be starting vaccination in the middle of 2021 with a cost of few hundred to few thousand per dose. Vaccine usually is a protein or synthetic peptides from Corona virus that can elicits humoral antibody (IgG) as well as T-cell mediated ability to destroy virus.

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References

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  8. Van Doremalen N., et al. “ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques”. Nature 586 (2020): 578-582.
  9. Chakraborty AK. “Coronavirus Nsp2 Protein Homologies to the Bacterial DNA Topoisomerase I and IV Suggest Nsp2 Protein is an Unique RNA Topoisomerase with Novel Target for Drug and Vaccine Development”. Virology and Mycology 9 (2020): 185.
  10. Chakraborty AK. “Unusual Enzymes in Corona Virus Genome and their Roles in Pathogenicity Control and Drug Design”. EC Emergency Medicine and Critical Care 9 (2020): 45-50.
  11. Fu L., et al. “Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease”. Nature Communications 1 (2020): 4417.
  12. Chakraborty AK., et al. “Multidrug Resistant Bacteria with Activated and Diversified MDR Genes in Kolkata Water: Ganga Action Plan and Heterogeneous Phyto Antibiotics Tackling Superbug Spread in India”. American Journal of Advanced Drug Delivery Therapy 1 (2018): 2.
  13. Tiri B., et al. “Antimicrobial Stewardship Program, COVID-19 and Infection Control: Spread of Carbapenem-Resistant Klebsiella Pneumoniae Colonization in ICU COVID-19 Patients. What Did Not Work?” Journal of Clinical Medicine 9 (2020): 2744.
  14. Vaillancourt M and Jorth P. “The Unrecognized Threat of Secondary Bacterial Infections with COVID-19”. M Bio4 (2020): e01806-e018020.
  15. Cantón R., et al. “Antimicrobial resistance in ICUs: an update in the light of the COVID-19 pandemic”. Current Opinion in Critical Care5 (2020): 433-441.
  16. Cole J and Barnard E. “The Impact of the COVID-19 Pandemic on Healthcare Acquired Infections with Multidrug Resistant Organisms”. American Journal of Infection Control 1 (2020): 5726.
  17. Chakraborty AK., et al. “An abundant new saponin-polybromophenol antibiotic (CU1) from Cassia fistula bark targeting RNA polymerase”. Bio Rxiv (2020).
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Citation

Citation: Asit Kumar Chakraborty. “Molecular Targets and Biotechnological Exploration on Corona-Virus and Multi-Drug Resistant Bacteria". Acta Scientific Biotechnology 1.12 (2020): 25-26.




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