Acta Scientific Biotechnology

Short Communication Volume 1 Issue 10

Enzyme Promiscuity and Molecular Mechanism; Mystery Remain Unsolved

Mahendra Kumar Verma1* and Samba Naik A2

1Scientist, Centre for Molecular Biology Research (CMBR) Bhopal, Madhya Pradesh, India
2Lecturer, Department of Zoology, KBN College, Vijayawada, Andhra Pradesh, India

*Corresponding Author: Mahendra Kumar Verma, Scientist, Centre for Molecular Biology Research (CMBR) Bhopal, Madhya Pradesh, India.

Received: September 17, 2020; Published: September 30, 2020


  Enzymes/proteins are the most versatile bio-molecules in the living system. In the living system, the enzyme catalyzes biochemical reactions in varying magnitude. The nature of the enzyme can be defined as robust and effective. It is believed enzymes are highly specific towards its substrate. At the same enzyme do catalyze multiple biochemical reactions at varying pace. There is growing research evidence suggests enzymes are highly promiscuous and capable of multiple binding substrates. Promiscuity is a phenomenon where enzymes do develop an affinity for various substrates and catalyze numerous biochemical reactions. Further, promiscuity is a natural phenomenon that can be at the substrate level and or at the catalytic level. However, recent studies have established artificial promiscuity called induced promiscuity. Induced promiscuity is entirely different from protein engineering, where a specific amino acid/s modified for the desired property. Over the last decade, growing research work was carried out to understand the nature and mechanism of enzyme promiscuity along with its commercial implication. Despite extensive research work on enzyme promiscuity still, we are unable to comprehend molecular insights of enzyme promiscuity. As a core area of green chemistry, enzyme promiscuity is crucial not only for the extended use of such unique molecules but also for sustainable development as well. The wide range of applications of enzymes, including healthcare, agriculture, industry, and food industry, the enzyme promiscuity had shown tremendous scope in the future.



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Citation: Mahendra Kumar Verma and Samba Naik A. “Enzyme Promiscuity and Molecular Mechanism; Mystery Remain Unsolved". Acta Scientific Biotechnology 1.10 (2020): 24-25.


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