Tomy Muringayil Joseph¹, Anoop Kallingal², Akshay Maniyeri Suresh³, Debarshi Kar Mahapatra⁴, Józef Haponiuk¹, Sabu Thomas⁵ and S Mohammad Sajadi⁶*

¹Department of Polymer Technology, Faculty of Chemistry, Gdańsk University of Technology, Poland
²Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Poland
³Laboratory of Bacterial Genetics, Faculty of Chemistry, Gdansk University of Technology, Poland
⁴Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, India
⁵International and Inter University Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam, India
⁶Department of Nutrition, Cihan University-Erbil, Kurdistan Region, Iraq

*Corresponding Author: S Mohammad Sajadi, Department of Nutrition, Cihan University-Erbil, Kurdistan Region, Iraq.

Received: August 24, 2022; Published: September 26, 2022

Abstract

In Jan 2022, Christopher JL Murray wrote a paper entitled “COVID-19 will continue but the end of the pandemic is near” (Lancet, 399, 417-419, 2022). He concluded that “After the omicron wave, COVID-19 will return but the pandemic will not.” After almost 6 months from that time, we experience new waves of the COVID-19 pandemic. Therefore, understanding solutions for COVID recurrence are indispensable. Vaccines, masks, sanitizers, and social stimulants are preventative measures, but maybe new variants of COVID-19 happen. Almost three years after COVID-19 outbreak, we still are not able to find a universal solution; beside some side-effects of vaccines are documented. In fact, poor nutrition may have an adverse effect on the immune system, leading to an inflammatory response, potentially explaining the higher risk of symptoms from infection with SARS-CoV-2. Nourishing the immune system with the nutrients gives the ability to fight against viral invasions in the human body. The possible existence of similar epidemic diseases impacts people all over the planet. This study concentrates on the benefits of nutrients such as vitamin D, vitamin C, and zinc and the impact of weather humidity on COVID-19 to get prepared for future cases in advance.

Keywords: Micronutrient; Pandemic; Vitamins; Zinc; Flavanoids; COVID-19; Medicine

References

1. Joseph TM. “Knowing What the COVID-19 Vaccine Does to Your Body?” International Journal of Current Research and Review 13 (2021): 1-1.
2. Rabiee N., et al. “Bioactive Hybrid Metal-Organic Framework (MOF)-Based Nanosensors for Optical Detection of Recombinant SARS-CoV-2 Spike Antigen”. Science of the Total Environment 825 (2022): 153902.
3. Aghamirza Moghim Aliabadi H., et al. “COVID-19: A Systematic Review and Update on Prevention, Diagnosis, and Treatment”. MedComm 3 (2022): e115.
4. Seidi F., et al. “Functionalized Masks: Powerful Materials against COVID-19 and Future Pandemics”. Small 17 (2021): 2102453.
5. Ahmadi S., et al. “Green Chemistry and Coronavirus”. Sustainable Chemistry and Pharmacy 21 (2021): 100415.
6. Deng C., et al. “Virucidal and Biodegradable Specialty Cellulose Nonwovens as Personal Protective Equipment against COVID-19 Pandemic”. Journal of Advanced Research (2021).
7. Domańska-Blicharz K., et al. “Animal Coronaviruses in the Light of COVID-19”. Journal of Veterinary Research 64 (2020): 333-345.
8. Callaway E. “The Coronavirus Is Mutating — Does It Matter?” Nature 585 (2020): 174-177.
9. Mobed A., et al. “Anti-Bacterial Activity of Gold Nanocomposites as a New Nanomaterial Weapon to Combat Photogenic Agents: Recent Advances and Challenges”. RSC Advances 11 (2021): 34688-34698.
10. Abdollahiyan P., et al. “Application of Cys A@AuNPs Supported Amino Acids towards Rapid and Selective Identification of Hg (II) and Cu (II) Ions in Aqueous Solution: An Innovative Microfluidic Paper-Based (ΜPADs) Colorimetric Sensing Platform”. Journal of Molecular Liquids 338 (2021): 117020.
11. Farshchi F., et al. “Architecture of a Multi-Channel and Easy-to-Make Microfluidic Paper-Based Colorimetric Device (ΜPCD) towards Selective and Sensitive Recognition of Uric Acid by AuNPs: An Innovative Portable Tool for the Rapid and Low-Cost Identification of Clinically Relevant Biomolecules”. RSC Advances 11 (2021): 27298-27308.
12. Saadati A., et al. “Biomedical Application of Hyperbranched Polymers: Recent Advances and Challenges”. TrAC Trends in Analytical Chemistry 142 (2021): 116308.
13. Enzymatic Recognition of Hydrogen Peroxide (H2O2) in Human Plasma Samples Using HRP Immobilized on the Surface of Poly (Arginine‐toluidine Blue)‐ Fe3O4 Nanoparticles Modified Polydopamine; A Novel Biosensor - Sardaremelli - 2021 - Journal of Molecular Recognition – Wiley.
14. Seidi F., et al. “Thiol-Lactam Initiated Radical Polymerization (TLIRP): Scope and Application for the Surface Functionalization of Nanoparticles”. Mini-Reviews in Organic Chemistry - Bentham Science 19 (2022): 416-431.
15. Farshchi F., et al. “Trifluralin Recognition Using Touch-Based Fingertip: Application of Wearable Glove-Based Sensor toward Environmental Pollution and Human Health Control”. Journal of Molecular Recognition 34 (2021): e2927.
16. Saadati A., et al. “A Microfluidic Paper-Based Colorimetric Device for the Visual Detection of Uric Acid in Human Urine Samples”. Analytical of Methods 13 (2021): 3909-3921.
17. Abdollahiyan P., et al. “An Innovative Colorimetric Platform for the Low-Cost and Selective Identification of Cu (II), Fe (III), and Hg (II) Using GQDs-DPA Supported Amino Acids by Microfluidic Paper-Based (ΜPADs) Device: Multicolor Plasmonic Patterns”. Journal of Environmental Chemical Engineering 9 (2021): 106197.
18. Saadati A., et al. “An Innovative Flexible and Portable DNA Based Biodevice towards Sensitive Identification of Haemophilus Influenzae Bacterial Genome: A New Platform for the Rapid and Low Cost Recognition of Pathogenic Bacteria Using Point of Care (POC) Analysis”. Microchemical Journal 169 (2021): 106610.
19. Seidi F., et al. “Biopolymer-Based Membranes from Polysaccharides for CO2 Separation: A Review”. Environmental Chemistry Letters 20 (2022): 1083-1128.
20. Shokri Z., et al. “Elucidating the Impact of Enzymatic Modifications on the Structure, Properties, and Applications of Cellulose, Chitosan, Starch and Their Derivatives: A Review”. Materials Today Chemistry 24 (2022): 100780.
21. Darvish Aminabad E., et al. “Sensitive Immunosensing of α-Synuclein Protein in Human Plasma Samples Using Gold Nanoparticles Conjugated with Graphene: An Innovative Immuno-Platform towards Early Stage Identification of Parkinson’s Disease Using Point of Care (POC) Analysis”. RSC Advances 12 (2022): 4346-4357.
22. Kholafazad-Kordasht H., et al. “Smartphone Based Immunosensors as next Generation of Healthcare Tools: Technical and Analytical Overview towards Improvement of Personalized Medicine”. TrAC Trends in Analytical Chemistry 145 (2021): 116455.
23. van de Veerdonk FL., et al. “A Guide to Immunotherapy for COVID-19”. Nature Medicine 28 (2022): 39-50.
24. Porfidia A and Pola R. “Venous Thromboembolism and Heparin Use in COVID-19 Patients: Juggling between Pragmatic Choices, Suggestions of Medical Societies and the Lack of Guidelines”. Journal of Thrombosis and Thrombolysis 50 (2020): 68-71.
25. Lowen AC., et al. “Influenza Virus Transmission Is Dependent on Relative Humidity and Temperature”. PLOS Pathogens 3 (2007): e151.
26. Winther B. “Rhinoviruses”. International Encyclopedia of Public Health (2008): 577-581.
27. Carter S. “Orthomolecular Medicine”. Integrative Clinical Medicine 18 (2019): 74.
28. Heyland DK., et al. “Antioxidant Nutrients: A Systematic Review of Trace Elements and Vitamins in the Critically Ill Patient”. Intensive Care Medicine 31 (2005): 327-337.
29. Caccialanza R., et al. “Early Nutritional Supplementation in Non-Critically Ill Patients Hospitalized for the 2019 Novel Coronavirus Disease (COVID-19): Rationale and Feasibility of a Shared Pragmatic Protocol”. Nutrition 74 (2020): 110835.
30. Yan T., et al. “Obesity and Severe Coronavirus Disease 2019: Molecular Mechanisms, Paths Forward, and Therapeutic Opportunities”. Theranostics 11 (2021): 8234-8253.
31. Tang G. “Bioconversion of Dietary Provitamin A Carotenoids to Vitamin A in Humans”. The American Journal of Clinical Nutrition 91 (2010): 1468S-1473S.
32. Antioxidants Support - Natural Supplements (2022).
33. Zhou E., et al. “Niacin Attenuates the Production of Pro-Inflammatory Cytokines in LPS-Induced Mouse Alveolar Macrophages by HCA2 Dependent Mechanisms”. International Immunopharmacology 23 (2014): 121-126.
34. Serseg T., et al. “Two Natural Compounds and Folic Acid as Potential Inhibitors of 2019-Novel Coronavirus Main Protease (2019- NCoVMpro), Molecular Docking and SAR Study”. Current Computer-Aided Drug Design 17 (2021): 469-479.
35. Cámara M., et al. “A Review of the Role of Micronutrients and Bioactive Compounds on Immune System Supporting to Fight against the COVID-19 Disease”. Foods 10 (2021): 1088.
36. Martineau AR., et al. “Vitamin D Supplementation to Prevent Acute Respiratory Tract Infections: Systematic Review and Meta-Analysis of Individual Participant Data”. BMJ 356 (2017): i6583.
37. Płudowski P., et al. “Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe — recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency”. Endokrynologia Polska 64 (2013): 319-327.
38. Holick MF., et al. “Endocrine Society Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline”. The Journal of Clinical Endocrinology and Metabolism 96 (2011): 1911-1930.
39. Marcinowska-Suchowierska E., et al. “Vitamin D Toxicity-A Clinical Perspective”. Frontiers in Endocrinology 9 (2018): 550.
40. Guo G., et al. “High Dose Intravenous Vitamin C as Adjunctive Therapy for COVID-19 Patients with Cancer: Two Cases”. Life 12 (2022): 335.
41. Chambial S., et al. “Vitamin C in Disease Prevention and Cure: An Overview”. Indian Journal of Clinical Biochemistry 28 (2013): 314-328.
42. De la Fuente M., et al. “Vitamin E Ingestion Improves Several Immune Functions in Elderly Men and Women”. Free Radical Research 42 (2008): 272-280.
43. Meydani SN., et al. “Vitamin E Supplementation and in Vivo Immune Response in Healthy Elderly Subjects. A Randomized Controlled Trial”. JAMA 277 (1997): 1380-1386.
44. Lee J., et al. “Developmental Toxicity of Intravenously Injected Zinc Oxide Nanoparticles in Rats”. Archives of Pharmacal Research 39 (2016): 1682-1692.
45. Ahmad S., et al. “Indian Medicinal Plants and Formulations and Their Potential Against COVID-19-Preclinical and Clinical Research”. Frontiers in Pharmacology 11 (2021).
46. Thomas S., et al. “Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial”. JAMA Network Open 4 (2021): e210369.
47. Vanek VW., et al. “Novel Nutrient Task Force, Parenteral Multi-Vitamin and Multi-Trace Element Working Group; et al. A.S.P.E.N. Position Paper”. Nutrition in Clinical Practice 27 (2012): 440-491.
48. Peterson JJ., et al. “Improving the Estimation of Flavonoid Intake for Study of Health Outcomes”. Nutritional Review 73 (2015): 553-576.

Citation

Citation: S Mohammad Sajadi., et al. “Orthomolecular Medicine Against COVID-19: Getting Prepared for Future Pandemic Recurrence". Acta Scientific Applied Physics 2.10 (2022): 10-13.

Copyright

Copyright: © 2022 S Mohammad Sajadi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.