Amrita Razdan Kaul¹*, Anita Kant² and Sumera Neha³

¹Senior Consultant, Asian Institute of Medical Sciences, Faridabad, Haryana, India
²Chairman and Head of OBG Dept., Asian Institute of Medical Sciences, Faridabad, Haryana, India
³MBBS, DNB, Asian Institute of Medical Sciences, Faridabad, Haryana, India

*Corresponding Author: Amrita Razdan Kaul, Senior Consultant, Asian Institute of Medical Sciences, Faridabad, Haryana, India.

Received: April 22, 2024; Published: June 28, 2024

Abstract

Introduction: Gestational Diabetes Mellitus (GDM) is considered as an early marker of glucose intolerance, associated with both insulin resistance and impaired insulin secretion. GDM also leads to substantial fetal morbidity and mortality. Multiple reports have demonstrated birth anomalies, growth restriction, obesity and macrosomia in the offspring of diabetic women. Vitamin D deficiency is also commonly observed during pregnancy. It is well documented that Vitamin D plays a role in improving insulin sensitivity and glucose tolerance. However, it is still unclear whether vitamin D deficiency induces GDM or whether supplementing vitamin D to deficient pregnant woman can prevent GDM and its adverse outcomes.

Aims: This study was carried out to elicit relationship between vitamin D deficiency and GDM in antinatal women.

Materials and Methods: In this observational cross-sectional study, 214 subjects were enrolled from the out - patients attending obstetrics services. A pregnant women undergoing clinical examination is given a 75 g oral glucose load between 24- 28 weeks of gestation, irrespective of her fasting or non-fasting state and time of last meal. GDM is diagnosed if 2 hour plasma glucose is ≥ 140 by GOD- POD (glucose oxidase- peroxidase) method. Their serum vitamin D levels are also assessed at the same time. Sample size and study subjects was calculated by: N= (Zα/2 +Zβ)*PQ*2/d2 All the data was compiled in a Microsoft Excel Sheet for various variables of interest which was presented in the form of graphs and tables appropriately. Pearson’s chi-square test was applied to find out the association between independent categorical data.

Results: In the present study we observed that 68 (31.4%) women were having GDM, deranged GCT was seen in another 73 women (34.11%). All 68 women with GDM belonged to the age group of 21-35 years and only one women out of 73 with deranged GCT was less than 20 years of age. We observed that majority of women were having sufficient levels of vitamin D (41.1%), 55(25.7%) had vitamin D deficiency and 71 (33.2%) had insufficient levels of vitamin D.

Conclusion: This study shows a weak correlation between GDM and Vitamin-D deficiency.

Keywords: 25-hydroxy-vitamin-D; Pregnancy; Gestational Diabetes Mellitus

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Citation

Citation: Amrita Razdan Kaul., et al. “Correlation of Vitamin D Levels and Gestational Diabetes Mellitus in Antenatal Women".Acta Scientific Women's Health 6.7 (2024): 47-51.

Copyright

Copyright: © 2024 Amrita Razdan Kaul., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.