Evidence for Olive Oil Supplementation as a Dementia Prevention Strategy
Magda Tsolaki*
Emeritus Professor of Neurology, Aristotle University of Thessaloniki, Chair of Greek Federation of Alzheimer’s Disease, Greece
*Corresponding Author: Magda Tsolaki, Emeritus Professor of Neurology, Aristotle University of Thessaloniki, Chair of Greek Federation of Alzheimer’s Disease, Greece.
Received: December 28, 2023; Published: March 31, 2024
Abstract
Mild cognitive impairment (MCI) is considered a cognitive decline disorder that does not meet the clinical criteria for dementia. Currently, there is not an effective and approved pharmacological agent for MCI in Europe, while a limited number of existing options for symptomatic treatment efficacy [3] are being used in Alzheimer’s disease (AD) with approval and in MCI without approval.
References
- Livingston G., et al. “Dementia prevention, intervention, and care: 2020 report of the Lancet Commission”. Lancet 10248 (2020): 413-446.
- Qosa H., et al. “Extra- virgin olive oil attenuates amyloid- and tau pathologies in the brains of TgSwDI mice”. The Journal of Nutritional Biochemistry 26 (2015): 1479-1490.
- Tsolaki M., et al. “A Randomized Clinical Trial of Greek High Phenolic Early Harvest Extra Virgin Olive Oil in Mild Cognitive Impairment: The MICOIL Pilot Study”. Journal of Alzheimer's Disease2 (2020): 801-817.
- Fillit HM., et al. “The State of Alzheimer’s Research and the Path Forward”. Journal of Prevention of Alzheimer's Disease 10 (2023): 617-619.
- Tzekaki EE., et al. “The multifunctional therapeutic potentiality of extra virgin olive oil administration through the intervention in pathophysiological mechanisms: Focus on Alzheimer's disease”. GSC Advanced Research and Reviews1 (2021): 101-113.
- Tzekaki EE., et al. “The pleiotropic beneficial intervention of olive oil intake on the Alzheimer's disease onset via fibrinolytic system”. Experimental Gerontology 150 (2021): 111344.
- Tzekaki EE., et al. “Restoration of BMI1 levels after the administration of early harvest extra virgin olive oil as a therapeutic strategy against Alzheimer's disease”. Experimental Gerontology 144 (2021): 111178.
- Tzekaki EE., et al. “Extra Virgin Olive Oil consumption from Mild Cognitive Impairment patients attenuates oxidative and nitrative stress reflecting on the reduction of the PARP levels and DNA damage”. Experimental Gerontology 156 (2021): 111621.
- Kaddoumi A., et al. “Extra-Virgin Olive Oil Enhances the Blood-Brain Barrier Function in Mild Cognitive Impairment: A Randomized Controlled Trial”. Nutrients23 (2022): 5102.
- Tsolaki M., et al. “Prevalence of Alzheimer's Disease and other dementing disorders in Pilea, Greece”. American Journal of Alzheimer΄s Disease 14 (1999): 138-148.
- Kosmidis MH., et al. “Dementia Prevalence in Greece: The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD)”. Alzheimer Disease and Associated Disorders3 (2018): 232-239.
Citation
Copyright