Determınation of Hepatıtıs E Vırus Infection Frequency and Risk Factors in Viral Hepatites in Diyarbakır Regıon
Songül Beskisiz1, Omer Satici2, Vatan Kavak3* and Kendal Yalcin4
1Department of Internal Medicine, Gazi Yaşargil Training and Research Hospital, University of Health Sciences, Diyarbakir, Turkey
2Department of Bitoistatics, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
3Department of Anatomy, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
4Department of Hepatology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
*Corresponding Author: Vatan Kavak, Department of Anatomy, Facultey of Medicine, Dicle University, Diyarbakir, Turkey.
May 18, 2021; Published: June 30, 2021
Aim: Our aim in this study; Liver in the domain of hepatitis E virus infection; It is the largest organ in the body located in the upper right of the abdominal cavity. The liver organ is the organ in the domain of the hepatitis E virus. It is to retrospectively investigate the HEV seropositivity in patients with viral hepatitis who are 18 years of age and older who applied to Dicle University Faculty of Medicine, Department of Gastroenterology, and to determine the risk factors associated with HEV infection by evaluating the cases according to epidemiological, clinical and laboratory characteristics.
Material and Methods: Within the scope of this study, 1025 patients aged 18 and over who applied to Dicle University Faculty of Medicine Gastroenterology Department between May 2011 and March 2015 were included. Age, gender, biochemistry (ALT, AST, GGT, Total bilirubin, albumin), whole blood (hemoglobin, thrombocyte), coagulation (INR), demographic criteria (origin (urban/rural), educational status (primary school and below-low, middle school and above-high), marital status (married/single), pregnancy (yes/no), known family history of viral hepatitis (yes/no), contact with animals, substance abuse (yes/no), alcohol use (yes/no no), cirrhosis status (yes/no), time of infection in patients with viral hepatitis, and antiviral drug use were retrospectively investigated.
Statistical Analysis: The data were transferred from the Excel package program to the SPSS (Statistical Package for Social Sciences) 25 package program. Variables were defined as categorical, ordered, and continuous measurement variables, and appropriate tests were used for these variables.
Results: The mean age of the patients was 49.29 ± 15.39 years and Anti-HEV IgG seropositivity was determined 56,4% of all patients (578/1025). HEV seropositivity was 76,3% in patients with HCV (29/38), 50% in patients with HBV (142/284), 70,7% in patients with HDV (58/82) and 56.2% in control group (349/621). Highest mean age in the groups was detected in HCV patients as 51.84 ± 15.77 years ( P = 0.001). Rate of Anti-HEV IgG seropositivity according to age groups was highest in patients older than 61 years old ( 141/578, 24.4%) and lowest in patients between 18-30 years old (68/578, 11.8%) (P < 0.001). Advanced age, rural origin, low education level, being married, history of contact with animals, high ALT levels, high GGT levels, low platelet levels, anti-delta seropositivity, ani-HCV seropositivity and anti-HAV IgG seropositivity was found to be significant risk factors for HEV seropositivity in the logistic regression analysis.
Conclusion: In this study, it was found that HEV infection is more common in people with low education levels in our region, people living in rural areas, elderly people, married people, those who are engaged in animal husbandry, and cirrhotic patients. In addition, ALT and GGT elevation, low platelets, anti-delta positive, anti-HCV positive and anti-HAV IgG positive were determined as risk factors for seropositivity in logistic regression analysis. These demographic findings may contribute to the determination of risky patients and taking preventive measures in the control of HEV infection. Accurate and permanent anatomy education provides the ability to comment 85% on all diseases. Therefore, in studies belonging to researchers; anatomy is important.
Keywords: Hepatitis E Virus; Hepatitis B Virus; Hepatitis C Virus; Hepatitis D Virus; Etiology; Epidemiology; Liver Anatomy
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