Dhekra Grami*, Soumaya Wahabi, Kaïs Rtibi, Slimen Selmi and Hichem Sebai

Université de Jendouba, Institut Supérieur de Biotechnologie de Beja, Laboratoire de Physiologie Fonctionnelle et Valorisation des Bioressources, Institut Supérieur de Biotechnologie de Béja, Tunisia

*Corresponding Author: Dhekra Grami, Université de Jendouba, Institut Supérieur de Biotechnologie de Beja, Laboratoire de Physiologie Fonctionnelle et Valorisation des Bioressources, Institut Supérieur de Biotechnologie de Béja, Tunisia.

Received: June 03, 2024; Published: July 31, 2024

Abstract

Crataegus monogyna has attracted particular attention of modern medicine because of its widespread use for the prevention and treatment of some human various diseases. Atorvastatin (ATV), a lipid lowering agent, are widely used in combination with drugs. However, the effect of Crataegus monogyna and Atorvastatin on the male reproductive system and fertility has not been clearly defined. The current investigation aimed to study the protective effect of Crataegus monogyna aqueous extract (CMAE) or Atorvastatin against histological damage and oxidative stress induced by High fat diet (HFD) in the testes of Wistar rats were used and divided into four groups of animal search; Groups I and II served as standard and HFD controls and had double distilled water. Groups III and IV were treated with CMAE and ATV respectively (300, 2.1mg/kg, b.w. p.o.). All of the doses were per orally (p.o.) during 12 weeks. Our result revealed that HFD-treatment induced significant testis histological damages proved by an induction of testicular dysfunction like a lower number of Leydig cells and spermatocytes as well as an oxidative stress status assessed by an increase of malondialdehyde (MDA) level and antioxidant enzyme activities as superoxide dismutase (SOD) and catalase (CAT) in testicular tissue. The administration of CMAE or ATV improved all histological injuries and biochemical parameters. These finding suggested that firstly the ability of CMAE to protect the testicular damages in rats might be related by pharmacologically active substances such phenolic compounds with higher antioxidant capacity. Secondly clearly indicates that ATV offers a significant protection against HFD-induced oxidative stress and histological damage in the testes of rat.

 Key words: Crataegus Monogyna; Atorvastatin; HFD; Histological Damage; Oxidative Stress; Rats

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Citation

Citation: Dhekra Grami., et al. “Crataegus Monogyna Alleviate Testicular Damage Induced by High Fat Diet in Albino Rats". Acta Scientific Veterinary Sciences 6.8 (2024): 68-75.

Copyright

Copyright: © 2024 Dhekra Grami., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.