D Vats¹*, D Nayak¹ S Chawla², SN Prabhu³ and SG Bhoge⁴

¹Institute Animal Facility, Department of Biological Science, IISER Bhopal, India
²Central Animal Research and Experimentation Facility (CARE), School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, India
³Department of Veterinary pathology, College of Veterinary Science, DUVASU, Mathura, India
⁴Department of Animal Husbandry, Government of Maharashtra, India

*Corresponding Author: D Vats, Institute Animal Facility, Department of Biological Science, IISER Bhopal, India.

Received: June 20, 2024; Published: June 25, 2024

Abstract

This report documents a sudden and fatal case of copulatory breeding trauma in a 7-month-old NOD SCID male breeder mouse. While similar injuries in other mouse strains typically result in recovery, the immunocompromised status of NOD SCID mice significantly impairs their healing abilities and heightens their susceptibility to infections. The mouse exhibited acute lethargy, gastrointestinal distress, and penile discharge, leading to death within a few hours. Postmortem examination revealed a significantly distended bladder with haemorrhagic spots, and urine analysis showed numerous motile sperm-like structures. The findings indicate that copulatory trauma was the primary cause of death, emphasizing the need for careful monitoring and preventive measures in breeding management, particularly for immunocompromised strains

 Keywords: NOD SCID Mouse; Breeding Trauma; Copulatory Injury; Laboratory Animals; Veterinary Pathology; Immunodeficient Mice; Reproductive Health

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Citation

Citation: D Vats., et al. “Exploring the Risks of Copulatory Trauma in Immunocompromised NOD SCID Mice". Acta Scientific Veterinary Sciences 6.7 (2024): 32-35.

Copyright

Copyright: © 2024 D Vats., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.