Syed Hassan Raza Shah¹, Muhammad Haseeb Qamar¹, Muhammad Hussain Ghazali³*, Sharafat Ali², Muhammad Bilal², Ahmad Fawad Khalil⁴, Hamad Ur Rehman⁵, Mustabshira Fatima⁶, Talha Mushtaq¹ and Riaz Ahmed Gul⁷

¹Department of Theriogenology, University of Agriculture (UAF), Faisalabad, Pakistan
²Department of Theriogenology, University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan
³School of Food and Biological Engineering, Jiangsu University (JSU) - Zhenjiang, China
⁴Department of Meat Science and Technology, University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan
⁵Poultry Research Institute (PRI), Rawalpindi, Pakistan
⁶Department of Epidemiology and Public Health, University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan
⁷Faculty of Veterinary and Animal sciences, The Islamia University of Bahawalpur

*Corresponding Author: Muhammad Hussain Ghazali, School of Food and Biological Engineering, Jiangsu University (JSU) - Zhenjiang, China.

Received: April 29, 2024Published: May 03, 2024

Abstract

One of the most crucial objectives of livestock husbandry is ensuring that the animals can reproduce without any interference. Each year, one live calf is the ultimate objective of breeding, which increases the milk supply through healthy pregnancies and reduces the time of uterus, spends in the involuted state. There is a long, varying period of sexual quiescence after giving birth. This phase with no cycles is commonly known as postpartum anestrus. The postpartum phase is an essential portion of reproductive life because of its enormous impact on future fertility. From the time of conception until the time when genital organs revert to their pre-pregnancy physiological status, a female is said to be in the postpartum period which is also known as the puerperium. This period is also referred to as the entire postpartum period. Postpartum injections of PGF2α, GnRH, and Oxytocin have been shown to enhance myometrium activity, which helps in clearing lochia after calving. As a result, such postpartum injections decrease uterine involution time and improve reproductive performance, all of which are attempts to reduce the rate of uterine infection, shorten the time it takes for the uterus to go through its natural process of involution, and resume ovarian function earlier. The reason for conducting this research was to summarize the impacts of uterine involution and ovarian resumption as they are influenced by various hormones, including PGF2α, GnRH, and Oxytocin, as well as other factors, including nutrition, season, and minerals.

Keywords: New Insights; Uterine; Ovarian; Resumption; Domestic Animals

References

1. Elena Barbieri., et al. “Journal of Veterinary Healthcare Issn No : 2575-1212”. Journal of Veterinary Health Care1 (2017): 21-38.
2. Gohar MA., et al. “Effect of Oxytetracycline treatment on postpartum reproductive performance in dairy buffalo-cows with retained placenta in Egypt”. Journal of Veterinary Healthcare3 (2018): 45-53.
3. Bajagić BZ. “Ispitivanje uticaja citološkog statusa endometrijuma, kvaliteta estralne sluzi i nivoa progesterona u momentu osemenjavanja na plodnost krava sa patološkim puerperijumom”. Univerzitet u Beogradu-Fakultet veterinarske medicine (2022).
4. Bajcsy ÁC., et al. “Characteristics of bovine early puerperal uterine contractility recorded under farm conditions”. Theriogenology1 (2005): 99-111.
5. Kindahl H., et al. “Endocrine aspects of uterine involution in the cow”. Reproduction in Domestic Animals3-4 (1999): 261-268.
6. Whitlow LW and Hagler WM. “Mycotoxins in dairy cattle: Occurrence, toxicity, prevention and treatment”. Southwest Nutr. Conf (2005): 124-138.
7. Roberts AJ., et al. “Circulating insulin-like growth factor I, insulin-like growth factor binding proteins, growth hormone, and resumption of estrus in postpartum cows subjected to dietary energy restriction”. Journal of Animal Science7 (1997): 1909-1917.
8. Gutiérrez CG., et al. “The recruitment of ovarian follicles is enhanced by increased dietary intake in heifers”. Journal of Animal Science7 (1997): 1876-1884.
9. Salmito-Vanderley CSB and Marques Júnior AP. “Involução uterina em cabras sem raça definida”. Revista Brasileira de Reprodução Animal3 (2004): 278-281.
10. Souza FA., et al. “Restrição alimentar e os mecanismos endócrinos associados ao desenvolvimento folicular ovariano em vacas”. Revista Brasileira de Reprodução Animal2 (2009): 61-65.
11. Kelley DE., et al. “Oral l-arginine supplementation impacts several reproductive parameters during the postpartum period in mares”. Animal Reproduction Science3-4 (2013): 233-240.
12. Silva LA., et al. “Relationship between vascularity of the preovulatory follicle and establishment of pregnancy in mares”. Animal Reproduction (AR)3 (2018): 339-346.
13. Norambuena MC., et al. “Effects of nutritional restriction on metabolic, endocrine, and ovarian function in llamas (Lama glama)”. Animal Reproduction Science3-4 (2013): 252-260.
14. Hafez ESE and Hafez B. “Reproduction in farm animals”. John Wiley and Sons (2013).
15. Carcangiu V., et al. “Blood melatonin levels relating to the reproductive activity of Sarda does”. Small Ruminant Research1 (2005): 7-13.
16. Jainudeen MR., et al. “Ovinos e caprinos”. Reprodução Animal. São Paulo, Brazil: Manole (2004): 335-347.
17. Cavilla MV., et al. “Ultrasonographic and endocrine characterization of follicular waves in llamas with a special reference to the overlapping phenomenon during successive waves”. Reproduction in Domestic Animals6 (2013): 923-930.
18. Morris LHA and Allen WR. “Reproductive efficiency of intensively managed Thoroughbred mares in Newmarket”. Equine Veterinary Journal1 (2002): 51-60.
19. Youngquist RS and Threlfall WR. “Current therapy in large animal theriogenology”. Elsevier Health Sciences (2006).
20. Elmetwally MA., et al. “Effects of parity on postpartum fertility parameters in Holstein dairy cows”. Journal of Agriculture and Veterinary Science 9 (2016): 91-99.
21. Lazarin GB., et al. “Plasma urea nitrogen and progesterone concentrations and follicular dynamics in ewes fed proteins of different degradability”. Revista Brasileira de Zootecnia 41 (2012): 1638-1647.
22. Somchit-Assavacheep A. “Influence of nutritional management on folliculogenesis in ewes”. The Thai Journal of Veterinary Medicine 41 (2011): 25.
23. de Medeiros Ferreira JR., et al. “Uterine Involution of Mares Supplemented with Dietary Algae-Derived Omega-3 Fatty Acids During the Peripartum Period”. Journal of Equine Veterinary Science 106 (2021): 103733.
24. El-Salaam A., et al. “Impact of Dietary Iodine Supplementation on Productive and Reproductive Performance of Maghrebian She-camels” (2018).
25. Abdel-Khalek A., et al. “Uterine Involution and Reproductive Performance of Lactating Friesian Cows Treated With Oxytocin and Prostaglandin (Pgf2Α) At Calving”. Journal of Animal and Poultry Production6 (2013): 349-362.
26. Ingawale MV., et al. “Effect of gnrh and pgf2α administration in early post partum period on fertility potential of buffaloes”. International Buffalo Information Center (IBIC) Buffalo Bulletin2 (2014): 228.
27. Nacu G., et al. “Research on the dynamics of uterine involution in cows treated with cloprostenol” (2017).
28. Benmrad M and Stevenson JS. “Gonadotropin-releasing hormone and prostaglandin F2α for postpartum dairy cows: Estrous, ovulation, and fertility traits”. Journal of Dairy Science3 (1986): 800-811.
29. Young IM and Anderson DB. “Improved reproductive performance from dairy cows treated with dinoprost tromethamine soon after calving”. Theriogenology2 (1986): 199-208.
30. White AJ and Dobson H. “Effect of prostaglandin F2 alpha on the fertility of dairy cows after calving”. The Veterinary Record24 (1990): 588-592.
31. Elsheikh AS., et al. “Management of Postpartum Interval of Nubian goats with PGF2α and GnRH”. Journal of American Science3 (2013): 181-184.
32. Noakes DE., et al. “Veterinary reproduction and obstetrics” (2009).
33. Ahmed MN., et al. “Ultrasonographic study of uterine involution in of Awassi ewes in Iraq”. Journal of Veterinary Science 1 (2016): 22-27.
34. Gündüz MC., et al. “The effect of oxytocin and PGF2α on the uterine involution and pregnancy rates in postpartum Arabian mares”. Animal Reproduction Science2-4 (2008): 257-263.
35. Nikolakopoulos E and Watson ED. “Uterine contractility is necessary for the clearance of intrauterine fluid but not bacteria after bacterial infusion in the mare”. Theriogenology3 (1999): 413-423.
36. Tibary A and Anouassi A. “Theriogenology in Camelidae: Anatomy”. Physiology, Pathology and Artificial Breeding (Rabat: Actes Editions Publ.) (1997).
37. Derar R., et al. “The postpartum period in dromedary camels: Uterine involution, ovarian activity, hormonal changes, and response to GnRH treatment”. Animal Reproduction Science3-4 (2014): 186-193.
38. Elmetwally MA. “Uterine involution and ovarian activity in postpartum Holstein dairy cows. A review”. Journal of Veterinary Healthcare4 (2018): 29.
39. Britt JH., et al. “Ovulation, estrus and endocrine response after GnRH in early postpartum cows”. Journal of Animal Science5 (1974): 915-919.
40. Kesler DJ., et al. “Reproductive hormones associated with normal and abnormal changes in ovarian follicles in postpartum dairy cows”. Journal of Dairy Science8 (1979): 1290-1296.
41. Gawish HA. “Resumption of Ovarian Cycles of Shami Goat Does Throughout Postpartum Period Using Gnrh Agonist and Pgf2Α Analogue”. Egyptian Journal of Animal Production2 (2008): 139-154.
42. Rawy MS. “Follicular Dynamics and Induction of Ovulation in Female Dromedary Camel”. V Sc Thesis, Department of Theriogenology, Faculty of Veterinary Medicine, Assiut University. Egypt (2011): 19-23.
43. Ismail ST., et al. “Superovualtion trials for embryo transfer in the camel (Camelus dromedarius)”. Scientific Journal of King Faisal University (Basic and Applied Science) 8 (2007): 51-59.
44. Collins SM., et al. “Continuous administration of low-dose GnRH in mares: II. Pituitary and ovarian responses to uninterrupted treatment beginning near the autumnal equinox and continuing throughout the anovulatory season”. Theriogenology4 (2007): 673-681.
45. Bajcsy ÁC., et al. “The effect of a single oxytocin or carbetocin treatment on uterine contractility in early postpartum dairy cows”. Theriogenology2 (2006): 400-414.
46. Mohamed MY., et al. “Effect of Oxytocin on uterine involution, cervical dilation and resumption of ovarian activity post-lambing in Ossimi ewes?”. Journal of Livestock Scienc 12 (2021): 161-169.
47. Vyas S and Sahani MS. “Real-time ultrasonography of ovaries and breeding of the one-humped camel (Camelus dromedarius) during the early postpartum period”. Animal Reproduction Science3-4 (2000): 179-184.
48. Gutjahr S., et al. “Effect of dose and day of treatment on uterine response to oxytocin in mares”. Theriogenology3 (2000): 447-456.
49. Madill S., et al. “Dose-response effect of intramuscular oxytocin treatment on myometrial contraction of reproductively normal mares during estrus”. Theriogenology2-4 (2002): 479-481.
50. Blanchard TL., et al. “Effects of ecbolic agents on measurements of uterine involution in the mare”. Theriogenology4 (1991): 559-571.

Citation

Citation: Muhammad Hussain Ghazali., et al. “New Insights in Uterine Involution and Ovarian Resumption in Domestic Animals". Acta Scientific Veterinary Sciences 6.6 (2024): 10-16.

Copyright

Copyright: © 2024 Muhammad Hussain Ghazali., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.